G12 - calcitonin receptor-like receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 16.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 246 - G.S3 F 223 G.S3.03
Hydrophobic TM6 K 333 6x37 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 333 6x37 G.H5 M 379 G.H5.24
Hydrophobic TM3 L 237 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 237 3x54 G.H5 I 378 G.H5.23
Polar TM3 V 242 3x59 G.H5 K 367 G.H5.12
Hydrophobic ICL2 V 245 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 V 245 - G.H5 I 370 G.H5.15
Hydrophobic ICL2 F 246 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 246 - G.S3 I 221 G.S3.01
Hydrophobic TM5 L 316 5x61 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 316 5x61 G.H5 L 375 G.H5.20
Hydrophobic ICL3 L 330 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 L 330 - G.H5 Q 372 G.H5.17
Hydrophobic TM6 L 341 6x45 G.H5 I 378 G.H5.23
Hydrophobic ICL2 F 246 - G.H5 V 366 G.H5.11
Van-der-waals ICL2 F 246 - G.H5 V 366 G.H5.11
Hydrophobic TM3 I 241 3x58 G.H5 L 375 G.H5.20
Hydrophobic ICL2 V 245 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 V 245 - G.H5 K 367 G.H5.12
Hydrophobic ICL2 F 246 - G.S1 V 58 G.S1.02
Van-der-waals ICL2 F 246 - G.S1 V 58 G.S1.02
Hydrophobic ICL3 E 327 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 E 327 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 L 330 - G.H5 M 379 G.H5.24
Ionic TM2 R 173 2x46 G.H5 D 377 G.H5.22
Polar TM2 R 173 2x46 G.H5 D 377 G.H5.22
Hydrophobic TM2 R 173 2x46 G.H5 D 377 G.H5.22
Van-der-waals TM2 R 173 2x46 G.H5 D 377 G.H5.22
Polar ICL3 E 327 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 E 327 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 L 330 - G.H5 K 376 G.H5.21
Polar TM6 K 333 6x37 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 333 6x37 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 F 246 - G.H5 K 367 G.H5.12
Hydrophobic ICL2 A 247 - G.hns1 R 56 G.hns1.03
Polar TM3 L 240 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 L 240 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 L 240 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM6 Y 331 6x35 G.H5 L 371 G.H5.16
Hydrophobic TM6 A 337 6x41 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 337 6x41 G.H5 M 379 G.H5.24
Hydrophobic TM6 A 334 6x38 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 334 6x38 G.H5 M 379 G.H5.24
Hydrophobic H8 N 388 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 388 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 241 3x58 G.H5 L 371 G.H5.16
Hydrophobic ICL2 F 246 - G.H5 I 370 G.H5.15
Hydrophobic TM3 I 241 3x58 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 241 3x58 G.H5 I 378 G.H5.23
Hydrophobic ICL2 K 249 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 K 249 - G.hns1 R 55 G.hns1.02
Aromatic ICL2 F 246 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 246 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 246 - G.H5 F 363 G.H5.08
Hydrophobic TM3 L 240 3x57 G.H5 I 378 G.H5.23
Hydrophobic TM6 Y 331 6x35 G.H5 L 375 G.H5.20
Polar H8 G 389 8x48 G.H5 L 380 G.H5.25
Hydrophobic H8 G 389 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 G 389 8x48 G.H5 L 380 G.H5.25
Hydrophobic TM7 F 384 7x57 G.H5 L 380 G.H5.25
Ionic TM5 K 319 5x64 G.H5 D 368 G.H5.13
Polar TM5 K 319 5x64 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 319 5x64 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 319 5x64 G.H5 D 368 G.H5.13
Hydrophobic ICL3 E 327 - G.S6 F 347 G.S6.02
Polar TM6 Y 331 6x35 G.H5 Q 372 G.H5.17
Hydrophobic TM6 Y 331 6x35 G.H5 Q 372 G.H5.17
Van-der-waals TM6 Y 331 6x35 G.H5 Q 372 G.H5.17
Hydrophobic TM6 A 334 6x38 G.H5 L 375 G.H5.20
Ionic ICL2 E 248 - G.hns1 R 56 G.hns1.03
Polar ICL2 E 248 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 E 248 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 E 248 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 K 249 - G.HN R 52 G.HN.52
Hydrophobic TM7 I 383 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 I 383 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM5 K 319 5x64 G.H5 L 371 G.H5.16