G13 - CCR10 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 76.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 144 3x56 G.S3 V 216 G.S3.01
Van-der-waals TM3 R 144 3x56 G.S3 V 216 G.S3.01
Hydrophobic TM7 L 313 7x56 G.H5 L 376 G.H5.25
Van-der-waals TM7 L 313 7x56 G.H5 L 376 G.H5.25
Hydrophobic TM3 I 142 3x54 G.H5 L 371 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 371 G.H5.20
Hydrophobic TM3 R 144 3x56 G.hns1 R 47 G.hns1.03
Van-der-waals TM3 R 144 3x56 G.hns1 R 47 G.hns1.03
Hydrophobic TM5 L 234 5x65 G.H5 M 375 G.H5.24
Polar TM2 S 75 2x37 G.hns1 K 46 G.hns1.02
Hydrophobic TM2 S 75 2x37 G.hns1 K 46 G.hns1.02
Van-der-waals TM2 S 75 2x37 G.hns1 K 46 G.hns1.02
Hydrophobic TM2 P 76 2x38 G.HN T 43 G.HN.52
Ionic TM6 E 241 6x29 G.H5 K 372 G.H5.21
Polar TM6 E 241 6x29 G.H5 K 372 G.H5.21
Hydrophobic TM6 E 241 6x29 G.H5 K 372 G.H5.21
Van-der-waals TM6 E 241 6x29 G.H5 K 372 G.H5.21
Hydrophobic H8 G 314 8x47 G.H5 Q 377 G.H5.26
Hydrophobic TM4 P 155 4x39 G.HN S 39 G.HN.48
Hydrophobic TM6 P 240 6x28 G.h4s6 P 341 G.h4s6.20
Van-der-waals TM6 P 240 6x28 G.h4s6 P 341 G.h4s6.20
Hydrophobic ICL2 A 145 - G.H5 L 367 G.H5.16
Van-der-waals ICL2 A 145 - G.H5 L 367 G.H5.16
Hydrophobic TM5 A 237 5x68 G.H5 H 368 G.H5.17
Van-der-waals TM5 A 237 5x68 G.H5 H 368 G.H5.17
Hydrophobic TM6 V 249 6x37 G.H5 M 375 G.H5.24
Van-der-waals TM6 V 249 6x37 G.H5 M 375 G.H5.24
Hydrophobic ICL2 P 147 - G.s2s3 K 214 G.s2s3.01
Van-der-waals ICL2 P 147 - G.s2s3 K 214 G.s2s3.01
Hydrophobic TM6 E 241 6x29 G.H5 D 369 G.H5.18
Van-der-waals TM6 E 241 6x29 G.H5 D 369 G.H5.18
Polar ICL3 R 238 - G.H5 H 368 G.H5.17
Hydrophobic ICL3 R 238 - G.H5 H 368 G.H5.17
Van-der-waals ICL3 R 238 - G.H5 H 368 G.H5.17
Hydrophobic TM3 I 142 3x54 G.H5 M 375 G.H5.24
Hydrophobic TM6 R 242 6x30 G.H5 K 372 G.H5.21
Van-der-waals TM6 R 242 6x30 G.H5 K 372 G.H5.21
Hydrophobic TM2 L 81 2x43 G.H5 Q 377 G.H5.26
Polar ICL1 A 73 12x51 G.hns1 K 46 G.hns1.02
Hydrophobic ICL1 A 73 12x51 G.hns1 K 46 G.hns1.02
Van-der-waals ICL1 A 73 12x51 G.hns1 K 46 G.hns1.02
Hydrophobic TM2 R 74 2x36 G.hns1 K 46 G.hns1.02
Van-der-waals TM2 R 74 2x36 G.hns1 K 46 G.hns1.02
Hydrophobic TM5 L 230 5x61 G.H5 M 375 G.H5.24
Van-der-waals TM5 L 230 5x61 G.H5 M 375 G.H5.24
Polar ICL2 G 149 - G.s2s3 N 215 G.s2s3.02
Hydrophobic ICL2 G 149 - G.s2s3 N 215 G.s2s3.02
Van-der-waals ICL2 G 149 - G.s2s3 N 215 G.s2s3.02
Hydrophobic TM6 A 245 6x33 G.H5 M 375 G.H5.24
Van-der-waals TM6 A 245 6x33 G.H5 M 375 G.H5.24
Hydrophobic TM6 R 244 6x32 G.H5 L 376 G.H5.25
Hydrophobic H8 R 316 8x49 G.hns1 K 46 G.hns1.02
Van-der-waals H8 R 316 8x49 G.hns1 K 46 G.hns1.02
Polar ICL3 G 239 - G.H5 H 368 G.H5.17
Hydrophobic ICL3 G 239 - G.H5 H 368 G.H5.17
Hydrophobic TM6 A 245 6x33 G.H5 K 372 G.H5.21
Van-der-waals TM6 A 245 6x33 G.H5 K 372 G.H5.21
Polar H8 R 316 8x49 G.H5 Q 377 G.H5.26
Hydrophobic H8 R 316 8x49 G.H5 Q 377 G.H5.26
Van-der-waals H8 R 316 8x49 G.H5 Q 377 G.H5.26
Hydrophobic TM6 V 248 6x36 G.H5 L 376 G.H5.25
Polar H8 Q 319 8x52 G.h3s5 N 283 G.h3s5.02
Van-der-waals H8 Q 319 8x52 G.h3s5 N 283 G.h3s5.02
Hydrophobic TM5 L 234 5x65 G.H5 H 368 G.H5.17
Van-der-waals TM5 L 234 5x65 G.H5 H 368 G.H5.17
Hydrophobic TM6 V 248 6x36 G.H5 M 375 G.H5.24
Hydrophobic TM4 P 155 4x39 G.HN T 43 G.HN.52
Van-der-waals TM4 P 155 4x39 G.HN T 43 G.HN.52
Polar TM2 S 78 2x40 G.hns1 K 46 G.hns1.02
Van-der-waals TM2 S 78 2x40 G.hns1 K 46 G.hns1.02
Polar ICL1 R 71 12x49 G.HN K 42 G.HN.51
Hydrophobic ICL1 R 71 12x49 G.HN K 42 G.HN.51
Van-der-waals ICL1 R 71 12x49 G.HN K 42 G.HN.51
Hydrophobic ICL2 A 145 - G.S3 V 216 G.S3.01
Van-der-waals ICL2 A 145 - G.S3 V 216 G.S3.01
Hydrophobic TM3 A 141 3x53 G.H5 L 371 G.H5.20
Hydrophobic ICL2 P 152 - G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 P 152 - G.hns1 R 47 G.hns1.03
Polar H8 L 315 8x48 G.H5 L 376 G.H5.25
Hydrophobic H8 L 315 8x48 G.H5 L 376 G.H5.25
Van-der-waals H8 L 315 8x48 G.H5 L 376 G.H5.25
Hydrophobic ICL2 A 145 - G.H5 L 371 G.H5.20
Van-der-waals ICL2 A 145 - G.H5 L 371 G.H5.20
Hydrophobic ICL1 A 72 12x50 G.HN K 42 G.HN.51
Polar TM3 R 138 3x50 G.H5 M 375 G.H5.24
Van-der-waals TM3 R 138 3x50 G.H5 M 375 G.H5.24
Polar H8 R 316 8x49 G.H5 L 376 G.H5.25
Van-der-waals H8 R 316 8x49 G.H5 L 376 G.H5.25
Polar TM6 R 242 6x30 G.H5 H 368 G.H5.17
Hydrophobic TM6 R 242 6x30 G.H5 H 368 G.H5.17
Van-der-waals TM6 R 242 6x30 G.H5 H 368 G.H5.17
Hydrophobic TM6 P 240 6x28 G.S6 Y 343 G.S6.02
Van-der-waals TM6 P 240 6x28 G.S6 Y 343 G.S6.02
Ionic TM6 E 241 6x29 G.h4s6 K 340 G.h4s6.19
Polar TM6 E 241 6x29 G.h4s6 K 340 G.h4s6.19
Van-der-waals TM6 E 241 6x29 G.h4s6 K 340 G.h4s6.19
Hydrophobic H8 L 315 8x48 G.h3s5 N 283 G.h3s5.02
Hydrophobic ICL1 A 73 12x51 G.HN K 42 G.HN.51
Van-der-waals ICL1 A 73 12x51 G.HN K 42 G.HN.51
Hydrophobic H8 G 314 8x47 G.H5 L 376 G.H5.25
Van-der-waals H8 G 314 8x47 G.H5 L 376 G.H5.25