Gi3 - CCR2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 T 77 2x39 G.H5 C 351 G.H5.23
Polar TM6 R 240 6x32 G.H5 Y 354 G.H5.26
Aromatic TM6 R 240 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 240 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 240 6x32 G.H5 Y 354 G.H5.26
Polar TM6 K 237 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 237 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 237 6x29 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 L 149 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL2 V 146 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL3 R 233 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 L 149 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 149 34x54 G.S3 L 194 G.S3.01
Polar C-term G 353 - G.H2 K 209 G.H2.05
Hydrophobic C-term G 353 - G.H2 K 209 G.H2.05
Van-der-waals C-term G 353 - G.H2 K 209 G.H2.05
Hydrophobic TM3 I 142 3x54 G.H5 I 344 G.H5.16
Polar TM4 T 155 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 T 155 4x40 G.HN R 24 G.HN.48
Hydrophobic TM6 K 237 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 K 237 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM3 I 142 3x54 G.H5 L 353 G.H5.25
Polar TM3 A 141 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 141 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 141 3x53 G.H5 N 347 G.H5.19
Polar TM6 A 241 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 241 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 241 6x33 G.H5 L 353 G.H5.25
Van-der-waals ICL2 V 146 34x51 G.s2s3 K 192 G.s2s3.01
Ionic ICL1 K 72 12x49 G.HN D 20 G.HN.44
Polar ICL1 K 72 12x49 G.HN D 20 G.HN.44
Hydrophobic C-term L 350 - G.H3 S 252 G.H3.11
Van-der-waals C-term L 350 - G.H3 S 252 G.H3.11
Hydrophobic TM6 A 241 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 A 145 34x50 G.H5 I 343 G.H5.15
Polar H8 E 310 8x48 G.H5 Y 354 G.H5.26
Hydrophobic H8 E 310 8x48 G.H5 Y 354 G.H5.26
Van-der-waals H8 E 310 8x48 G.H5 Y 354 G.H5.26
Hydrophobic C-term P 364 - G.hfs2 V 179 G.hfs2.03
Hydrophobic ICL2 L 149 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 L 149 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 R 138 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 T 228 5x64 G.H5 I 344 G.H5.16
Ionic ICL2 K 150 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 K 150 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 K 150 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 K 150 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM3 I 142 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 348 G.H5.20
Ionic ICL2 R 152 34x57 G.H5 E 350 G.H5.22
Polar ICL2 R 152 34x57 G.H5 E 350 G.H5.22
Hydrophobic ICL2 R 152 34x57 G.H5 E 350 G.H5.22
Van-der-waals ICL2 R 152 34x57 G.H5 E 350 G.H5.22
Hydrophobic TM6 I 245 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 244 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 244 6x36 G.H5 L 353 G.H5.25
Polar ICL2 R 152 34x57 G.H5 N 347 G.H5.19
Hydrophobic TM5 L 229 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 229 5x65 G.H5 L 348 G.H5.20
Polar TM2 C 75 2x37 G.H5 E 350 G.H5.22
Hydrophobic TM2 C 75 2x37 G.H5 E 350 G.H5.22
Van-der-waals TM2 C 75 2x37 G.H5 E 350 G.H5.22
Hydrophobic ICL2 V 146 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 146 34x51 G.S3 L 194 G.S3.01
Hydrophobic C-term L 368 - H.hbhc E 115 H.hbhc.03
Van-der-waals C-term L 368 - H.hbhc E 115 H.hbhc.03
Ionic TM6 K 236 6x28 G.h4s6 D 315 G.h4s6.09
Polar TM6 K 236 6x28 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 K 236 6x28 G.h4s6 D 315 G.h4s6.09
Polar TM6 K 237 6x29 G.h4s6 T 316 G.h4s6.10
Hydrophobic TM6 K 237 6x29 G.h4s6 T 316 G.h4s6.10
Hydrophobic ICL2 K 150 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 L 149 34x54 G.hns1 K 32 G.hns1.03
Polar TM6 N 234 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 N 234 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 N 234 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM5 C 232 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 C 232 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 C 232 5x68 G.H5 D 341 G.H5.13
Hydrophobic C-term K 371 - H.HA R 86 H.HA.24
Van-der-waals C-term K 371 - H.HA R 86 H.HA.24
Hydrophobic ICL2 V 146 34x51 G.s2s3 D 193 G.s2s3.02
Polar H8 G 309 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 G 309 8x47 G.H5 G 352 G.H5.24
Polar C-term L 351 - G.H2 K 209 G.H2.05
Hydrophobic C-term L 351 - G.H2 K 209 G.H2.05
Van-der-waals C-term L 351 - G.H2 K 209 G.H2.05
Hydrophobic ICL2 A 145 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM4 V 154 4x39 G.HN R 24 G.HN.48
Van-der-waals TM4 V 154 4x39 G.HN R 24 G.HN.48
Polar TM4 V 154 4x39 G.HN E 28 G.HN.52
Polar C-term D 352 - G.H2 K 209 G.H2.05
Hydrophobic C-term D 352 - G.H2 K 209 G.H2.05
Van-der-waals C-term D 352 - G.H2 K 209 G.H2.05
Polar TM3 R 138 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 A 145 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 I 248 6x40 G.H5 L 353 G.H5.25
Hydrophobic TM4 T 153 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 T 153 4x38 G.HN E 28 G.HN.52
Hydrophobic TM3 A 141 3x53 G.H5 C 351 G.H5.23
Hydrophobic C-term S 359 - G.hfs2 G 183 G.hfs2.07
Hydrophobic ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 233 - G.h4s6 E 318 G.h4s6.12
Polar ICL2 R 152 34x57 G.H5 C 351 G.H5.23
Hydrophobic C-term L 351 - G.H2 R 208 G.H2.04
Van-der-waals C-term L 351 - G.H2 R 208 G.H2.04