Gq - CCR2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 152 34x57 G.H5 N 352 G.H5.19
Polar TM4 T 153 4x38 G.HN R 34 G.HN.52
Hydrophobic TM6 K 237 6x29 G.H5 V 359 G.H5.26
Van-der-waals TM6 K 237 6x29 G.H5 V 359 G.H5.26
Hydrophobic C-term A 363 - G.H4 D 315 G.H4.17
Van-der-waals C-term A 363 - G.H4 D 315 G.H4.17
Polar C-term G 361 - G.H4 K 311 G.H4.13
Van-der-waals C-term G 361 - G.H4 K 311 G.H4.13
Hydrophobic TM5 L 229 5x65 G.H5 L 353 G.H5.20
Van-der-waals TM5 L 229 5x65 G.H5 L 353 G.H5.20
Hydrophobic TM3 I 142 3x54 G.H5 L 353 G.H5.20
Polar TM7 Y 305 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 Y 305 7x53 G.H5 N 357 G.H5.24
Polar TM7 A 306 7x54 G.H5 N 357 G.H5.24
Polar ICL2 K 150 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 K 150 34x55 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 K 150 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic TM6 I 245 6x37 G.H5 L 358 G.H5.25
Hydrophobic ICL2 L 149 34x54 G.S1 L 40 G.S1.02
Hydrophobic TM6 V 244 6x36 G.H5 L 358 G.H5.25
Van-der-waals TM6 V 244 6x36 G.H5 L 358 G.H5.25
Polar TM2 T 77 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM2 T 77 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 T 77 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 142 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 142 3x54 G.H5 L 349 G.H5.16
Hydrophobic C-term L 368 - G.H5 F 339 G.H5.06
Van-der-waals C-term L 368 - G.H5 F 339 G.H5.06
Ionic TM6 K 237 6x29 G.h4s6 D 321 G.h4s6.12
Polar TM6 K 237 6x29 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM6 K 237 6x29 G.h4s6 D 321 G.h4s6.12
Van-der-waals TM6 K 237 6x29 G.h4s6 D 321 G.h4s6.12
Polar TM3 A 141 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 141 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 141 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM6 R 240 6x32 G.H5 V 359 G.H5.26
Van-der-waals TM6 R 240 6x32 G.H5 V 359 G.H5.26
Polar TM3 R 138 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 A 145 34x50 G.H5 I 348 G.H5.15
Hydrophobic TM3 R 138 3x50 G.H5 L 358 G.H5.25
Polar TM3 D 137 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 137 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 137 3x49 G.H5 Y 356 G.H5.23
Polar TM4 T 155 4x40 G.HN R 34 G.HN.52
Hydrophobic TM4 T 155 4x40 G.HN R 34 G.HN.52
Van-der-waals TM4 T 155 4x40 G.HN R 34 G.HN.52
Hydrophobic ICL2 V 146 34x51 G.H5 F 341 G.H5.08
Polar TM2 C 75 2x37 G.H5 E 355 G.H5.22
Hydrophobic TM2 C 75 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 C 75 2x37 G.H5 E 355 G.H5.22
Hydrophobic TM6 A 241 6x33 G.H5 V 359 G.H5.26
Hydrophobic ICL2 V 146 34x51 G.S3 V 199 G.S3.01
Van-der-waals ICL2 V 146 34x51 G.S3 V 199 G.S3.01
Hydrophobic C-term E 365 - G.H4 E 307 G.H4.09
Van-der-waals C-term E 365 - G.H4 E 307 G.H4.09
Hydrophobic TM3 I 142 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 142 3x54 G.H5 L 358 G.H5.25
Hydrophobic TM5 T 228 5x64 G.H5 L 349 G.H5.16
Polar TM5 C 232 5x68 G.H5 Q 350 G.H5.17
Hydrophobic TM5 C 232 5x68 G.H5 Q 350 G.H5.17
Van-der-waals TM5 C 232 5x68 G.H5 Q 350 G.H5.17
Hydrophobic H8 G 309 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 G 309 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM3 A 141 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 141 3x53 G.H5 Y 356 G.H5.23
Polar ICL2 R 152 34x57 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 R 152 34x57 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 R 152 34x57 G.H5 Y 356 G.H5.23
Polar TM6 A 241 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 241 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 A 241 6x33 G.H5 L 358 G.H5.25
Ionic ICL2 R 152 34x57 G.H5 E 355 G.H5.22
Polar ICL2 R 152 34x57 G.H5 E 355 G.H5.22
Hydrophobic ICL2 R 152 34x57 G.H5 E 355 G.H5.22
Van-der-waals ICL2 R 152 34x57 G.H5 E 355 G.H5.22
Hydrophobic TM5 C 232 5x68 G.H5 L 349 G.H5.16
Hydrophobic ICL2 L 149 34x54 G.H5 I 348 G.H5.15
Polar TM5 C 232 5x68 G.H5 D 346 G.H5.13
Van-der-waals TM5 C 232 5x68 G.H5 D 346 G.H5.13
Polar ICL2 K 150 34x55 G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL2 K 150 34x55 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 K 150 34x55 G.s2s3 S 198 G.s2s3.02
Polar ICL1 K 74 12x51 G.hns1 R 37 G.hns1.02
Van-der-waals ICL1 K 74 12x51 G.hns1 R 37 G.hns1.02
Hydrophobic C-term A 363 - G.H4 K 311 G.H4.13