Gs - CELSR1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 64.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 E 2562 3x60 G.H5 Q 384 G.H5.16
Hydrophobic TM3 E 2562 3x60 G.H5 Q 384 G.H5.16
Van-der-waals TM3 E 2562 3x60 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 Y 2645 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 Y 2645 - G.H5 R 385 G.H5.17
Hydrophobic TM3 M 2559 3x57 G.H5 L 393 G.H5.25
Van-der-waals TM3 M 2559 3x57 G.H5 L 393 G.H5.25
Polar TM6 G 2649 6x34 G.H5 L 393 G.H5.25
Hydrophobic TM6 G 2649 6x34 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 2649 6x34 G.H5 L 393 G.H5.25
Polar ICL3 Y 2645 - G.h4s6 H 357 G.h4s6.13
Hydrophobic ICL2 V 2563 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 2563 - G.H5 R 380 G.H5.12
Hydrophobic C-term L 2738 - G.H2 I 235 G.H2.08
Hydrophobic H8 Q 2706 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 Q 2706 8x48 G.H5 E 392 G.H5.24
Van-der-waals C-term A 2731 - G.h2s4 N 239 G.h2s4.02
Polar TM3 T 2561 3x59 G.H5 Q 384 G.H5.16
Van-der-waals TM3 T 2561 3x59 G.H5 Q 384 G.H5.16
Aromatic ICL3 Y 2645 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 Y 2645 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 Y 2645 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic C-term L 2882 - G.H2 K 233 G.H2.06
Polar C-term T 2849 - G.hgh4 R 317 G.hgh4.07
Hydrophobic C-term T 2849 - G.hgh4 R 317 G.hgh4.07
Van-der-waals C-term T 2849 - G.hgh4 R 317 G.hgh4.07
Polar ICL2 R 2564 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 R 2564 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 R 2564 - G.H5 H 387 G.H5.19
Hydrophobic C-term K 2930 - H.HF R 199 H.HF.06
Van-der-waals C-term K 2930 - H.HF R 199 H.HF.06
Hydrophobic C-term W 2863 - G.h2s4 F 238 G.h2s4.01
Van-der-waals C-term W 2863 - G.h2s4 F 238 G.h2s4.01
Polar TM3 L 2560 3x58 G.H5 Q 384 G.H5.16
Polar TM5 R 2640 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 R 2640 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 R 2640 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 Y 2645 - G.H5 L 394 G.H5.26
Hydrophobic TM5 H 2643 5x67 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 2643 5x67 G.H5 R 385 G.H5.17
Hydrophobic ICL3 G 2646 - G.H5 L 394 G.H5.26
Van-der-waals ICL3 G 2646 - G.H5 L 394 G.H5.26
Hydrophobic TM6 L 2653 6x38 G.H5 L 393 G.H5.25
Polar C-term T 2735 - G.h2s4 D 240 G.h2s4.03
Hydrophobic TM3 L 2560 3x58 G.H5 L 388 G.H5.20
Van-der-waals C-term W 2863 - G.H3 N 279 G.H3.15
Polar C-term L 2734 - G.h2s4 N 239 G.h2s4.02
Hydrophobic C-term L 2734 - G.h2s4 N 239 G.h2s4.02
Hydrophobic C-term W 2863 - G.H2 I 235 G.H2.08
Hydrophobic C-term L 2882 - G.hfs2 G 206 G.hfs2.07
Polar TM6 I 2650 6x35 G.H5 L 393 G.H5.25
Hydrophobic TM6 I 2650 6x35 G.H5 L 393 G.H5.25
Van-der-waals TM6 I 2650 6x35 G.H5 L 393 G.H5.25
Polar ICL2 V 2563 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 V 2563 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 V 2563 - G.H5 H 387 G.H5.19
Hydrophobic C-term V 2890 - G.h1ha V 65 G.h1ha.01
Ionic H8 K 2710 8x52 G.H5 E 392 G.H5.24
Polar H8 K 2710 8x52 G.H5 E 392 G.H5.24
Hydrophobic H8 K 2710 8x52 G.H5 E 392 G.H5.24
Van-der-waals H8 K 2710 8x52 G.H5 E 392 G.H5.24
Hydrophobic C-term A 2731 - G.h2s4 D 240 G.h2s4.03
Van-der-waals C-term A 2731 - G.h2s4 D 240 G.h2s4.03
Polar ICL2 N 2565 - G.H5 Q 390 G.H5.22
Polar ICL2 D 2567 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 D 2567 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 D 2567 - G.H5 Y 391 G.H5.23
Hydrophobic TM3 M 2559 3x57 G.H5 L 388 G.H5.20
Hydrophobic TM3 M 2559 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 M 2559 3x57 G.H5 Y 391 G.H5.23
Aromatic TM5 H 2643 5x67 G.S6 Y 360 G.S6.02
Hydrophobic TM5 H 2643 5x67 G.S6 Y 360 G.S6.02
Van-der-waals TM5 H 2643 5x67 G.S6 Y 360 G.S6.02
Hydrophobic ICL3 Y 2645 - G.h4s6 G 355 G.h4s6.11
Hydrophobic TM6 I 2650 6x35 G.H5 L 388 G.H5.20
Hydrophobic C-term A 2861 - G.H3 N 271 G.H3.07
Hydrophobic C-term I 2928 - G.H5 T 369 G.H5.01
Van-der-waals C-term I 2928 - G.H5 T 369 G.H5.01
Hydrophobic C-term V 2888 - G.H1 R 61 G.H1.09
Hydrophobic C-term L 2929 - H.HF D 194 H.HF.01
Polar ICL2 N 2565 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 N 2565 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 N 2565 - G.H5 Y 391 G.H5.23
Hydrophobic C-term T 2728 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 V 2563 - G.H5 Q 384 G.H5.16
Polar ICL2 N 2565 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 N 2565 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 N 2565 - G.H5 H 387 G.H5.19
Hydrophobic TM5 H 2643 5x67 G.S6 P 361 G.S6.03
Polar H8 E 2707 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 E 2707 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 E 2707 8x49 G.H5 E 392 G.H5.24
Hydrophobic C-term K 2930 - G.s6h5 V 367 G.s6h5.04
Van-der-waals C-term K 2930 - G.s6h5 V 367 G.s6h5.04
Hydrophobic C-term L 2734 - G.H3 W 281 G.H3.17
Van-der-waals C-term L 2734 - G.H3 W 281 G.H3.17
Hydrophobic C-term K 2930 - H.HF Q 195 H.HF.02
Van-der-waals C-term K 2930 - H.HF Q 195 H.HF.02
Hydrophobic C-term L 2738 - G.H3 W 281 G.H3.17
Polar C-term A 2861 - G.H3 S 275 G.H3.11
Polar C-term T 2735 - G.h2s4 N 239 G.h2s4.02
Hydrophobic C-term T 2735 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term T 2735 - G.h2s4 N 239 G.h2s4.02
Hydrophobic ICL2 V 2563 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 2563 - G.H5 I 383 G.H5.15
Hydrophobic C-term I 2928 - G.s6h5 V 367 G.s6h5.04
Van-der-waals C-term I 2928 - G.s6h5 V 367 G.s6h5.04