Ggust - CX3CR1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 S 64 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 64 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 64 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM5 C 221 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 C 221 5x68 G.H5 I 344 G.H5.16
Ionic H8 K 299 8x49 G.H5 D 350 G.H5.22
Polar TM6 A 229 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 229 6x33 G.H5 L 353 G.H5.25
Polar ICL3 N 223 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 N 223 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 N 223 - G.h4s6 E 318 G.h4s6.12
Van-der-waals C-term L 355 - G.H3 S 252 G.H3.11
Van-der-waals C-term R 331 - G.h2s4 E 216 G.h2s4.02
Hydrophobic ICL2 M 138 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 M 138 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 A 134 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM3 I 131 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 131 3x54 G.H5 I 344 G.H5.16
Polar ICL2 N 139 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 139 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 139 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 218 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM6 A 229 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 218 5x65 G.H5 L 348 G.H5.20
Polar TM2 T 66 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 66 2x39 G.H5 C 351 G.H5.23
Polar ICL3 K 222 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 K 222 - G.H5 D 341 G.H5.13
Hydrophobic TM3 R 127 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 127 3x50 G.H5 L 353 G.H5.25
Polar ICL2 N 136 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 N 136 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 136 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 L 232 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 232 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 T 217 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM6 K 225 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 225 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 A 135 34x51 G.S3 L 194 G.S3.01
Polar TM3 A 130 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 130 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 130 3x53 G.H5 N 347 G.H5.19
Polar TM3 R 127 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 127 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 A 134 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 134 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM4 T 142 4x38 G.HN E 28 G.HN.52
Polar ICL2 R 141 34x57 G.H5 C 351 G.H5.23
Ionic TM6 K 225 6x29 G.h4s6 D 316 G.h4s6.10
Polar TM6 K 225 6x29 G.h4s6 D 316 G.h4s6.10
Van-der-waals TM6 K 225 6x29 G.h4s6 D 316 G.h4s6.10
Hydrophobic TM3 I 131 3x54 G.H5 L 353 G.H5.25
Polar TM6 H 224 6x28 G.h4s6 K 314 G.h4s6.08
Polar H8 G 297 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 G 297 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 297 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 I 131 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 131 3x54 G.H5 L 348 G.H5.20
Polar TM6 K 228 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 228 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 228 6x32 G.H5 F 354 G.H5.26
Hydrophobic C-term L 355 - G.H3 H 256 G.H3.15
Hydrophobic ICL3 K 222 - G.h4s6 E 318 G.h4s6.12
Polar H8 E 298 8x48 G.H5 F 354 G.H5.26
Polar H8 R 301 8x51 G.H5 F 354 G.H5.26
Hydrophobic TM6 I 233 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL3 N 223 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 N 223 - G.H5 K 345 G.H5.17
Polar ICL2 N 139 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM3 A 130 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 130 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 M 138 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 M 138 34x54 G.H5 I 343 G.H5.15
Polar TM5 C 221 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 C 221 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 C 221 5x68 G.H5 D 341 G.H5.13
Polar C-term R 331 - G.H3 Y 258 G.H3.17
Hydrophobic C-term R 331 - G.H3 Y 258 G.H3.17
Van-der-waals C-term R 331 - G.H3 Y 258 G.H3.17
Hydrophobic ICL2 M 138 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 M 138 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 A 135 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL3 K 222 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 M 138 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 M 138 34x54 G.S3 L 194 G.S3.01
Ionic ICL2 R 141 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 141 34x57 G.H5 D 350 G.H5.22