G14 - CXCR1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 13.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 135 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 135 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM6 R 239 6x32 G.H5 V 355 G.H5.26
Van-der-waals TM6 R 239 6x32 G.H5 V 355 G.H5.26
Polar ICL2 A 142 34x50 G.hns1 R 34 G.hns1.03
Hydrophobic ICL2 A 142 34x50 G.hns1 R 34 G.hns1.03
Van-der-waals ICL2 A 142 34x50 G.hns1 R 34 G.hns1.03
Hydrophobic TM3 I 139 3x54 G.H5 L 345 G.H5.16
Van-der-waals TM3 I 139 3x54 G.H5 L 345 G.H5.16
Hydrophobic TM5 A 232 5x68 G.H5 L 345 G.H5.16
Van-der-waals TM5 A 232 5x68 G.H5 L 345 G.H5.16
Hydrophobic ICL3 M 234 - G.H5 Q 346 G.H5.17
Van-der-waals ICL3 M 234 - G.H5 Q 346 G.H5.17
Polar TM7 Y 305 7x53 G.H5 N 353 G.H5.24
Hydrophobic TM7 Y 305 7x53 G.H5 N 353 G.H5.24
Van-der-waals TM7 Y 305 7x53 G.H5 N 353 G.H5.24
Hydrophobic TM2 S 72 2x37 G.H5 E 351 G.H5.22
Hydrophobic TM3 I 139 3x54 G.H5 L 354 G.H5.25
Van-der-waals TM3 I 139 3x54 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 146 34x54 G.hns1 R 34 G.hns1.03
Van-der-waals ICL2 L 146 34x54 G.hns1 R 34 G.hns1.03
Polar C-term Y 339 - G.h4s6 E 317 G.h4s6.12
Hydrophobic C-term Y 339 - G.h4s6 E 317 G.h4s6.12
Van-der-waals C-term Y 339 - G.h4s6 E 317 G.h4s6.12
Polar C-term S 341 - G.h4s6 E 317 G.h4s6.12
Hydrophobic C-term S 341 - G.h4s6 E 317 G.h4s6.12
Van-der-waals C-term S 341 - G.h4s6 E 317 G.h4s6.12
Hydrophobic TM3 D 134 3x49 G.H5 F 352 G.H5.23
Hydrophobic TM5 L 229 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM3 A 138 3x53 G.H5 F 352 G.H5.23
Van-der-waals TM3 A 138 3x53 G.H5 F 352 G.H5.23
Hydrophobic TM6 A 240 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 A 240 6x33 G.H5 L 349 G.H5.20
Polar C-term Y 339 - G.H5 R 350 G.H5.21
Aromatic C-term Y 339 - G.H5 R 350 G.H5.21
Hydrophobic C-term Y 339 - G.H5 R 350 G.H5.21
Van-der-waals C-term Y 339 - G.H5 R 350 G.H5.21
Hydrophobic ICL2 A 142 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 A 142 34x50 G.H5 I 344 G.H5.15
Hydrophobic C-term Y 339 - G.h4s6 D 315 G.h4s6.10
Van-der-waals C-term Y 339 - G.h4s6 D 315 G.h4s6.10
Polar TM3 R 135 3x50 G.H5 N 353 G.H5.24
Hydrophobic ICL2 T 143 34x51 G.H5 F 337 G.H5.08
Hydrophobic C-term V 344 - G.h4s6 V 319 G.h4s6.20
Polar TM6 Q 236 6x29 G.h4s6 E 317 G.h4s6.12
Van-der-waals TM6 Q 236 6x29 G.h4s6 E 317 G.h4s6.12
Polar ICL2 H 151 34x59 G.HN K 30 G.HN.52
Hydrophobic ICL2 H 151 34x59 G.HN K 30 G.HN.52
Van-der-waals ICL2 H 151 34x59 G.HN K 30 G.HN.52
Polar C-term N 345 - G.H4 Q 310 G.H4.16
Polar TM6 Q 236 6x29 G.H5 Q 346 G.H5.17
Van-der-waals TM6 Q 236 6x29 G.H5 Q 346 G.H5.17
Polar H8 Q 310 8x48 G.H5 V 355 G.H5.26
Hydrophobic H8 Q 310 8x48 G.H5 V 355 G.H5.26
Van-der-waals H8 Q 310 8x48 G.H5 V 355 G.H5.26
Hydrophobic H8 G 309 8x47 G.H5 V 355 G.H5.26
Van-der-waals H8 G 309 8x47 G.H5 V 355 G.H5.26
Hydrophobic TM6 V 243 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 V 243 6x36 G.H5 L 354 G.H5.25
Hydrophobic C-term V 346 - G.S6 Y 321 G.S6.02
Hydrophobic TM6 I 244 6x37 G.H5 L 354 G.H5.25
Polar TM6 Q 236 6x29 G.H5 R 350 G.H5.21
Hydrophobic ICL2 T 147 34x55 G.hns1 A 32 G.hns1.01
Van-der-waals ICL2 T 147 34x55 G.hns1 A 32 G.hns1.01
Hydrophobic C-term S 338 - G.h4s6 E 317 G.h4s6.12
Van-der-waals C-term S 338 - G.h4s6 E 317 G.h4s6.12
Polar C-term S 343 - G.h4s6 K 316 G.h4s6.11
Van-der-waals C-term S 343 - G.h4s6 K 316 G.h4s6.11
Polar TM6 A 240 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 240 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 A 240 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 Q 236 6x29 G.H5 V 355 G.H5.26
Van-der-waals TM6 Q 236 6x29 G.H5 V 355 G.H5.26
Polar TM3 R 135 3x50 G.H5 F 352 G.H5.23
Hydrophobic TM3 R 135 3x50 G.H5 F 352 G.H5.23
Van-der-waals TM3 R 135 3x50 G.H5 F 352 G.H5.23
Polar C-term S 342 - G.h4s6 K 316 G.h4s6.11
Hydrophobic C-term S 342 - G.h4s6 K 316 G.h4s6.11
Van-der-waals C-term S 342 - G.h4s6 K 316 G.h4s6.11
Hydrophobic ICL3 M 234 - G.H5 L 345 G.H5.16
Van-der-waals ICL3 M 234 - G.H5 L 345 G.H5.16
Polar ICL2 T 143 34x51 G.hns1 R 34 G.hns1.03
Hydrophobic ICL2 T 143 34x51 G.hns1 R 34 G.hns1.03
Van-der-waals ICL2 T 143 34x51 G.hns1 R 34 G.hns1.03
Polar TM3 A 138 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 138 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 138 3x53 G.H5 N 348 G.H5.19
Polar ICL3 H 233 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 H 233 - G.H5 D 342 G.H5.13
Hydrophobic ICL2 T 147 34x55 G.hns1 R 33 G.hns1.02
Hydrophobic C-term L 350 - G.H5 A 338 G.H5.09
Polar ICL2 T 145 34x53 G.hns1 R 34 G.hns1.03
Hydrophobic ICL2 T 145 34x53 G.hns1 R 34 G.hns1.03
Van-der-waals ICL2 T 145 34x53 G.hns1 R 34 G.hns1.03
Hydrophobic TM2 T 74 2x39 G.H5 F 352 G.H5.23
Van-der-waals TM2 T 74 2x39 G.H5 F 352 G.H5.23
Hydrophobic ICL2 T 143 34x51 G.H5 K 341 G.H5.12
Hydrophobic C-term T 340 - G.h4s6 K 316 G.h4s6.11
Van-der-waals C-term T 340 - G.h4s6 K 316 G.h4s6.11
Hydrophobic TM6 A 240 6x33 G.H5 V 355 G.H5.26
Polar C-term Y 339 - G.h3s5 L 261 G.h3s5.01
Polar H8 N 311 8x49 G.H5 R 350 G.H5.21
Hydrophobic H8 N 311 8x49 G.H5 R 350 G.H5.21
Van-der-waals H8 N 311 8x49 G.H5 R 350 G.H5.21
Polar C-term Y 339 - G.h3s5 N 262 G.h3s5.02
Van-der-waals C-term Y 339 - G.h3s5 N 262 G.h3s5.02
Hydrophobic TM3 I 139 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM5 L 229 5x65 G.H5 L 345 G.H5.16
Polar C-term S 342 - G.h4s6 E 317 G.h4s6.12
Hydrophobic C-term S 342 - G.h4s6 E 317 G.h4s6.12
Van-der-waals C-term S 342 - G.h4s6 E 317 G.h4s6.12
Hydrophobic H8 G 309 8x47 G.H5 N 353 G.H5.24
Hydrophobic ICL2 T 147 34x55 G.HN K 30 G.HN.52
Van-der-waals ICL2 T 147 34x55 G.HN K 30 G.HN.52
Hydrophobic ICL2 T 143 34x51 G.S3 I 195 G.S3.01
Van-der-waals ICL2 T 143 34x51 G.S3 I 195 G.S3.01
Hydrophobic ICL2 L 146 34x54 G.H5 I 344 G.H5.15
Polar C-term T 340 - G.h4s6 E 317 G.h4s6.12
Hydrophobic C-term T 340 - G.h4s6 E 317 G.h4s6.12
Van-der-waals C-term T 340 - G.h4s6 E 317 G.h4s6.12
Ionic ICL2 R 150 34x58 G.H5 E 351 G.H5.22
Polar ICL2 R 150 34x58 G.H5 E 351 G.H5.22
Polar TM3 H 141 3x56 G.hns1 R 34 G.hns1.03
Hydrophobic ICL3 M 234 - G.H5 L 349 G.H5.20
Van-der-waals ICL3 M 234 - G.H5 L 349 G.H5.20
Polar C-term Y 339 - G.h4s6 K 316 G.h4s6.11
Polar TM2 T 74 2x39 G.H5 E 351 G.H5.22
Van-der-waals TM2 T 74 2x39 G.H5 E 351 G.H5.22
Hydrophobic C-term S 342 - G.h4s6 V 319 G.h4s6.20
Van-der-waals C-term S 342 - G.h4s6 V 319 G.h4s6.20