G15 - CXCR2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
CXCR2 77.2
subunit alpha-15 85.9
Gβ1 92.1
Gγ2 83.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 R 144 3x50 G.H5 I 371 G.H5.23
Hydrophobic TM3 R 144 3x50 G.H5 I 371 G.H5.23
Van-der-waals TM3 R 144 3x50 G.H5 I 371 G.H5.23
Hydrophobic TM6 R 248 6x32 G.h4s6 R 335 G.h4s6.17
Van-der-waals TM6 R 248 6x32 G.h4s6 R 335 G.h4s6.17
Hydrophobic TM6 A 249 6x33 G.H5 L 368 G.H5.20
Hydrophobic C-term P 346 - G.H3 P 265 G.H3.16
Van-der-waals C-term P 346 - G.H3 P 265 G.H3.16
Van-der-waals C-term T 359 - G.H2 R 216 G.H2.04
Polar C-term S 357 - G.H2 K 213 G.H2.01
Hydrophobic C-term S 357 - G.H2 K 213 G.H2.01
Van-der-waals C-term S 357 - G.H2 K 213 G.H2.01
Polar H8 F 321 8x50 G.H5 N 372 G.H5.24
Hydrophobic H8 F 321 8x50 G.H5 N 372 G.H5.24
Hydrophobic C-term L 360 - G.H3 L 264 G.H3.15
Hydrophobic C-term L 360 - G.H2 W 219 G.H2.07
Polar TM6 Q 245 6x29 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM6 Q 245 6x29 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM6 Q 245 6x29 G.h4s6 R 338 G.h4s6.20
Polar C-term S 357 - G.s4h3 E 248 G.s4h3.14
Hydrophobic ICL2 Q 157 34x56 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 Q 157 34x56 G.hns1 R 40 G.hns1.02
Polar H8 Q 319 8x48 G.h4s6 G 333 G.h4s6.15
Van-der-waals H8 Q 319 8x48 G.h4s6 G 333 G.h4s6.15
Van-der-waals TM2 T 83 2x39 G.H5 I 371 G.H5.23
Van-der-waals ICL3 G 244 - G.h4s6 R 338 G.h4s6.20
Hydrophobic C-term L 360 - G.H3 T 260 G.H3.11
Polar H8 Q 319 8x48 G.H5 L 374 G.H5.26
Hydrophobic H8 Q 319 8x48 G.H5 L 374 G.H5.26
Van-der-waals H8 Q 319 8x48 G.H5 L 374 G.H5.26
Hydrophobic C-term L 360 - G.h2s4 F 223 G.h2s4.01
Van-der-waals C-term L 360 - G.h2s4 F 223 G.h2s4.01
Hydrophobic C-term P 346 - G.H3 W 266 G.H3.17
Van-der-waals C-term P 346 - G.H3 W 266 G.H3.17
Polar ICL3 H 242 - G.H5 D 361 G.H5.13
Van-der-waals ICL3 H 242 - G.H5 D 361 G.H5.13
Hydrophobic TM3 I 148 3x54 G.H5 L 373 G.H5.25
Hydrophobic TM2 S 81 2x37 G.H5 E 370 G.H5.22
Polar C-term K 342 - G.h3s5 K 268 G.h3s5.01
Van-der-waals C-term K 342 - G.h3s5 K 268 G.h3s5.01
Polar TM7 Y 314 7x53 G.H5 N 372 G.H5.24
Hydrophobic TM3 I 148 3x54 G.H5 L 364 G.H5.16
Hydrophobic TM3 R 144 3x50 G.H5 L 373 G.H5.25
Van-der-waals TM3 R 144 3x50 G.H5 L 373 G.H5.25
Hydrophobic C-term T 358 - G.H3 E 253 G.H3.04
Hydrophobic TM6 V 252 6x36 G.H5 L 373 G.H5.25
Van-der-waals TM6 V 252 6x36 G.H5 L 373 G.H5.25
Hydrophobic C-term T 358 - G.H3 L 257 G.H3.08
Hydrophobic ICL3 M 243 - G.H5 A 365 G.H5.17
Polar ICL2 R 153 34x52 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 R 153 34x52 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 R 153 34x52 G.H5 Y 367 G.H5.19
Polar ICL2 Q 157 34x56 G.HN K 37 G.HN.52
Hydrophobic ICL2 Q 157 34x56 G.HN K 37 G.HN.52
Polar H8 Q 319 8x48 G.h4s6 R 335 G.h4s6.17
Hydrophobic H8 Q 319 8x48 G.h4s6 R 335 G.h4s6.17
Van-der-waals H8 Q 319 8x48 G.h4s6 R 335 G.h4s6.17
Polar H8 K 320 8x49 G.H5 E 370 G.H5.22
Hydrophobic H8 K 320 8x49 G.H5 E 370 G.H5.22
Hydrophobic TM5 A 241 5x68 G.H5 L 364 G.H5.16
Hydrophobic TM3 I 148 3x54 G.H5 L 368 G.H5.20
Van-der-waals TM3 I 148 3x54 G.H5 L 368 G.H5.20
Hydrophobic ICL3 M 243 - G.H5 D 361 G.H5.13
Van-der-waals ICL3 M 243 - G.H5 D 361 G.H5.13
Hydrophobic C-term L 360 - G.H3 L 257 G.H3.08
Polar TM6 Q 245 6x29 G.h4s6 R 335 G.h4s6.17
Hydrophobic TM6 Q 245 6x29 G.h4s6 R 335 G.h4s6.17
Van-der-waals TM6 Q 245 6x29 G.h4s6 R 335 G.h4s6.17
Hydrophobic C-term T 358 - G.H3 A 256 G.H3.07
Hydrophobic H8 G 318 8x47 G.H5 N 372 G.H5.24
Polar C-term S 344 - G.h3s5 K 268 G.h3s5.01
Van-der-waals C-term S 344 - G.h3s5 K 268 G.h3s5.01
Hydrophobic TM5 L 238 5x65 G.H5 L 368 G.H5.20
Hydrophobic C-term L 360 - G.H3 I 261 G.H3.12
Van-der-waals C-term L 360 - G.H3 I 261 G.H3.12
Polar TM6 R 248 6x32 G.H5 L 374 G.H5.26
Hydrophobic TM6 R 248 6x32 G.H5 L 374 G.H5.26
Van-der-waals TM6 R 248 6x32 G.H5 L 374 G.H5.26
Polar ICL3 H 242 - G.H5 K 357 G.H5.09
Aromatic ICL3 H 242 - G.H5 K 357 G.H5.09
Hydrophobic ICL3 H 242 - G.H5 K 357 G.H5.09
Van-der-waals ICL3 H 242 - G.H5 K 357 G.H5.09
Hydrophobic ICL3 M 243 - G.H5 L 364 G.H5.16
Van-der-waals ICL3 M 243 - G.H5 L 364 G.H5.16
Polar C-term S 339 - G.h4s6 K 332 G.h4s6.14
Hydrophobic C-term F 348 - G.H2 I 220 G.H2.08
Van-der-waals C-term F 348 - G.H2 I 220 G.H2.08
Van-der-waals H8 G 318 8x47 G.H5 L 374 G.H5.26
Hydrophobic TM5 L 238 5x65 G.H5 L 364 G.H5.16
Hydrophobic TM3 I 148 3x54 G.H5 I 371 G.H5.23
Hydrophobic ICL3 M 243 - G.h4s6 R 338 G.h4s6.20
Van-der-waals ICL3 M 243 - G.h4s6 R 338 G.h4s6.20
Aromatic C-term F 348 - G.H3 W 266 G.H3.17
Hydrophobic C-term F 348 - G.H3 W 266 G.H3.17
Van-der-waals C-term F 348 - G.H3 W 266 G.H3.17
Hydrophobic TM6 Q 245 6x29 G.H5 L 374 G.H5.26
Van-der-waals TM6 Q 245 6x29 G.H5 L 374 G.H5.26
Polar TM6 A 249 6x33 G.H5 L 373 G.H5.25
Hydrophobic TM6 A 249 6x33 G.H5 L 373 G.H5.25
Van-der-waals TM6 A 249 6x33 G.H5 L 373 G.H5.25
Hydrophobic TM6 I 253 6x37 G.H5 L 373 G.H5.25
Hydrophobic ICL3 M 243 - G.H5 L 368 G.H5.20
Van-der-waals ICL3 M 243 - G.H5 L 368 G.H5.20