Gs - FPR2/ALX complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 P 239 6x33 G.H5 L 394 G.H5.26
Hydrophobic TM3 V 127 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 127 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 130 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL2 P 130 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 130 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM7 V 305 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 V 305 7x56 G.H5 E 392 G.H5.24
Hydrophobic ICL3 M 233 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 M 233 - G.H5 D 381 G.H5.13
Polar ICL2 R 137 34x57 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 224 5x61 G.H5 L 388 G.H5.20
Polar TM5 K 231 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 231 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 231 5x68 G.H5 Q 384 G.H5.16
Polar TM3 D 122 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 130 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 V 131 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM4 T 138 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM5 I 224 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 V 131 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 V 131 34x51 G.S3 V 217 G.S3.01
Polar TM3 V 127 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 127 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 127 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 M 233 - G.H5 L 394 G.H5.26
Van-der-waals ICL3 M 233 - G.H5 L 394 G.H5.26
Hydrophobic ICL3 M 233 - G.H5 L 388 G.H5.20
Van-der-waals ICL3 M 233 - G.H5 L 388 G.H5.20
Polar H8 Q 307 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 Q 307 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 Q 307 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL3 M 233 - G.H5 R 385 G.H5.17
Hydrophobic ICL2 N 135 34x55 G.hns1 A 39 G.hns1.03
Ionic TM5 K 231 5x68 G.H5 D 381 G.H5.13
Polar TM5 K 231 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 231 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 I 228 5x65 G.H5 L 393 G.H5.25
Polar TM2 T 60 2x39 G.H5 Q 390 G.H5.22
Hydrophobic TM2 T 60 2x39 G.H5 Q 390 G.H5.22
Van-der-waals TM2 T 60 2x39 G.H5 Q 390 G.H5.22
Polar ICL2 N 135 34x55 G.HN Q 35 G.HN.52
Polar ICL2 Q 134 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 Q 134 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 Q 134 34x54 G.hns1 R 38 G.hns1.02
Ionic TM6 R 238 6x32 G.H5 E 392 G.H5.24
Polar TM6 R 238 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 R 238 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 238 6x32 G.H5 E 392 G.H5.24
Polar TM3 C 126 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 C 126 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 C 126 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 C 126 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 C 126 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 K 227 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 227 5x64 G.H5 Q 384 G.H5.16
Hydrophobic H8 G 306 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 G 306 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM3 R 123 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM6 P 239 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 P 239 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 V 242 6x36 G.H5 L 393 G.H5.25
Polar ICL2 N 135 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 Q 134 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL3 M 233 - G.H5 Q 384 G.H5.16
Hydrophobic TM5 I 228 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 I 228 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL3 K 235 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 L 243 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM2 T 60 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 131 34x51 G.H5 F 376 G.H5.08