G12 - FPR3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 19.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals ICL2 N 135 34x55 G.S3 I 221 G.S3.01
Hydrophobic ECL2 I 177 45x51 G.HN R 6 G.HN.06
Van-der-waals ECL2 I 177 45x51 G.HN R 6 G.HN.06
Polar ICL2 N 135 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 N 135 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 N 135 34x55 G.hns1 R 56 G.hns1.03
Polar ECL2 F 178 45x52 G.HN G 3 G.HN.03
Hydrophobic ECL2 F 178 45x52 G.HN G 3 G.HN.03
Van-der-waals ECL2 F 178 45x52 G.HN G 3 G.HN.03
Hydrophobic TM6 F 243 6x37 G.H5 I 378 G.H5.23
Hydrophobic TM7 I 284 7x34 G.HN V 5 G.HN.05
Hydrophobic TM5 F 201 5x39 G.HN V 4 G.HN.04
Van-der-waals TM5 F 201 5x39 G.HN V 4 G.HN.04
Hydrophobic TM5 F 194 5x32 G.HN T 7 G.HN.07
Van-der-waals TM5 F 194 5x32 G.HN T 7 G.HN.07
Polar TM6 Y 257 6x51 G.HN M 1 G.HN.01
Hydrophobic TM6 Y 257 6x51 G.HN M 1 G.HN.01
Van-der-waals TM6 Y 257 6x51 G.HN M 1 G.HN.01
Hydrophobic ICL2 P 130 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 130 34x50 G.H5 I 370 G.H5.15
Hydrophobic ECL2 N 179 - G.HN L 8 G.HN.08
Van-der-waals ECL2 N 179 - G.HN L 8 G.HN.08
Hydrophobic ECL2 F 180 - G.HN T 7 G.HN.07
Van-der-waals ECL2 F 180 - G.HN T 7 G.HN.07
Hydrophobic TM5 I 228 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 I 228 5x65 G.H5 L 375 G.H5.20
Polar H8 R 307 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 R 307 8x48 G.H5 L 380 G.H5.25
Hydrophobic ICL3 M 233 - G.H5 L 375 G.H5.20
Van-der-waals ICL3 M 233 - G.H5 L 375 G.H5.20
Hydrophobic ICL3 M 233 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 M 233 - G.H5 L 371 G.H5.16
Hydrophobic ICL2 P 130 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL3 I 234 - G.H5 M 379 G.H5.24
Van-der-waals ICL3 I 234 - G.H5 M 379 G.H5.24
Hydrophobic ICL3 M 233 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 M 233 - G.H5 Q 372 G.H5.17
Hydrophobic H8 G 306 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 G 306 8x47 G.H5 L 380 G.H5.25
Polar ECL2 F 180 - G.HN C 11 G.HN.11
Hydrophobic ECL2 F 180 - G.HN C 11 G.HN.11
Van-der-waals ECL2 F 180 - G.HN C 11 G.HN.11
Hydrophobic ICL2 Q 134 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 Q 134 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM4 W 164 4x65 G.HN R 6 G.HN.06
Hydrophobic ECL2 I 177 45x51 G.HN S 9 G.HN.09
Van-der-waals ECL2 I 177 45x51 G.HN S 9 G.HN.09
Hydrophobic TM4 W 164 4x65 G.HN S 2 G.HN.02
Van-der-waals ICL2 Q 134 34x54 G.h2s4 T 246 G.h2s4.05
Polar ECL2 A 181 - G.HN C 11 G.HN.11
Hydrophobic ECL2 A 181 - G.HN C 11 G.HN.11
Van-der-waals ECL2 A 181 - G.HN C 11 G.HN.11
Hydrophobic TM2 Y 64 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 Y 64 2x43 G.H5 L 380 G.H5.25
Polar ECL2 N 179 - G.HN S 9 G.HN.09
Hydrophobic ECL2 N 179 - G.HN S 9 G.HN.09
Van-der-waals ECL2 N 179 - G.HN S 9 G.HN.09
Hydrophobic TM3 V 127 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 127 3x54 G.H5 L 375 G.H5.20
Polar ECL2 N 179 - G.HN R 10 G.HN.10
Hydrophobic ECL2 N 179 - G.HN R 10 G.HN.10
Van-der-waals ECL2 N 179 - G.HN R 10 G.HN.10
Van-der-waals TM2 R 81 2x60 G.HN R 6 G.HN.06
Polar TM2 R 81 2x60 G.HN S 2 G.HN.02
Hydrophobic TM2 R 81 2x60 G.HN S 2 G.HN.02
Hydrophobic ECL2 I 177 45x51 G.HN T 7 G.HN.07
Hydrophobic N-term S 6 - G.HN L 8 G.HN.08
Van-der-waals N-term S 6 - G.HN L 8 G.HN.08
Hydrophobic TM4 W 164 4x65 G.HN G 3 G.HN.03
Van-der-waals TM4 W 164 4x65 G.HN G 3 G.HN.03
Hydrophobic TM6 M 264 6x58 G.HN V 5 G.HN.05
Van-der-waals TM6 M 264 6x58 G.HN V 5 G.HN.05
Polar ICL3 K 235 - G.h4s6 R 342 G.h4s6.11
Hydrophobic TM5 F 194 5x32 G.HN L 8 G.HN.08
Van-der-waals TM5 F 194 5x32 G.HN L 8 G.HN.08
Hydrophobic TM6 G 261 6x55 G.HN M 1 G.HN.01
Van-der-waals TM6 G 261 6x55 G.HN M 1 G.HN.01
Hydrophobic TM5 I 224 5x61 G.H5 L 375 G.H5.20
Hydrophobic ECL2 F 182 - G.HN L 12 G.HN.12
Hydrophobic TM5 F 194 5x32 G.HN V 4 G.HN.04
Van-der-waals TM5 F 194 5x32 G.HN V 4 G.HN.04
Hydrophobic TM5 K 227 5x64 G.H5 L 371 G.H5.16
Van-der-waals TM5 K 227 5x64 G.H5 L 371 G.H5.16
Ionic ECL1 E 89 - G.HN R 6 G.HN.06
Polar ECL1 E 89 - G.HN R 6 G.HN.06
Hydrophobic ECL1 E 89 - G.HN R 6 G.HN.06
Van-der-waals ECL1 E 89 - G.HN R 6 G.HN.06
Polar TM3 C 126 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 C 126 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 C 126 3x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 Q 134 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 V 127 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 127 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM5 L 191 5x29 G.HN L 8 G.HN.08
Polar H8 N 308 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 308 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 308 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM7 Y 302 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 302 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM3 V 127 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 127 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM6 E 258 6x52 G.HN M 1 G.HN.01
Van-der-waals TM6 E 258 6x52 G.HN M 1 G.HN.01
Polar TM2 N 60 2x39 G.H5 D 377 G.H5.22
Polar ECL2 F 178 45x52 G.HN T 7 G.HN.07
Hydrophobic ECL2 F 178 45x52 G.HN T 7 G.HN.07
Van-der-waals ECL2 F 178 45x52 G.HN T 7 G.HN.07
Hydrophobic TM5 A 198 5x36 G.HN V 4 G.HN.04
Van-der-waals TM5 A 198 5x36 G.HN V 4 G.HN.04
Hydrophobic ECL2 I 167 - G.HN R 10 G.HN.10
Van-der-waals ECL2 I 167 - G.HN R 10 G.HN.10
Hydrophobic TM5 H 205 5x43 G.HN M 1 G.HN.01
Hydrophobic H8 R 307 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 R 307 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM4 T 138 4x38 G.HN R 52 G.HN.52
Polar N-term S 6 - G.HN S 9 G.HN.09
Hydrophobic N-term S 6 - G.HN S 9 G.HN.09
Van-der-waals N-term S 6 - G.HN S 9 G.HN.09
Hydrophobic TM7 L 281 7x31 G.HN V 5 G.HN.05
Hydrophobic ECL3 L 272 - G.HN L 8 G.HN.08
Van-der-waals ECL3 L 272 - G.HN L 8 G.HN.08
Hydrophobic TM5 L 202 5x40 G.HN M 1 G.HN.01
Van-der-waals TM5 L 202 5x40 G.HN M 1 G.HN.01
Polar TM2 S 84 2x63 G.HN R 6 G.HN.06
Van-der-waals TM2 S 84 2x63 G.HN R 6 G.HN.06
Hydrophobic ECL2 A 181 - G.HN S 9 G.HN.09
Van-der-waals ECL2 A 181 - G.HN S 9 G.HN.09
Polar ECL2 S 168 - G.HN R 10 G.HN.10
Hydrophobic ECL2 S 168 - G.HN R 10 G.HN.10
Van-der-waals ECL2 S 168 - G.HN R 10 G.HN.10
Polar ECL2 N 179 - G.HN T 7 G.HN.07
Hydrophobic ECL2 N 179 - G.HN T 7 G.HN.07
Van-der-waals ECL2 N 179 - G.HN T 7 G.HN.07
Polar ECL2 C 176 45x50 G.HN R 6 G.HN.06
Hydrophobic ECL2 C 176 45x50 G.HN R 6 G.HN.06
Van-der-waals ECL2 C 176 45x50 G.HN R 6 G.HN.06
Hydrophobic TM3 C 126 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 130 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 130 34x50 G.H5 K 367 G.H5.12
Polar ECL2 F 182 - G.HN C 11 G.HN.11
Hydrophobic ECL2 F 182 - G.HN C 11 G.HN.11
Van-der-waals ECL2 F 182 - G.HN C 11 G.HN.11
Hydrophobic ICL2 A 131 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 A 131 34x51 G.S3 I 221 G.S3.01
Polar TM4 S 140 4x40 G.HN R 52 G.HN.52
Hydrophobic TM4 S 140 4x40 G.HN R 52 G.HN.52
Van-der-waals TM4 S 140 4x40 G.HN R 52 G.HN.52
Polar ECL2 N 179 - G.HN C 11 G.HN.11
Hydrophobic ECL2 N 179 - G.HN C 11 G.HN.11
Van-der-waals ECL2 N 179 - G.HN C 11 G.HN.11
Polar ICL2 H 136 34x56 G.hns1 R 56 G.hns1.03
Aromatic ICL2 H 136 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 136 34x56 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 H 136 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic ECL2 F 178 45x52 G.HN V 4 G.HN.04
Polar TM3 R 123 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 I 378 G.H5.23
Hydrophobic ECL2 I 167 - G.HN S 9 G.HN.09
Van-der-waals ECL2 I 167 - G.HN S 9 G.HN.09
Hydrophobic TM5 F 201 5x39 G.HN M 1 G.HN.01
Polar ICL3 K 235 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 K 235 - G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 P 239 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 P 239 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM7 M 305 7x56 G.H5 L 380 G.H5.25