G14 - FZD9 complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 76.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 27.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 K 440 - G.H5 V 355 G.H5.26
Polar ICL1 Q 261 12x51 G.h3s5 N 262 G.h3s5.02
Polar TM2 P 263 2x40 G.H5 E 351 G.H5.22
Hydrophobic TM2 P 263 2x40 G.H5 E 351 G.H5.22
Van-der-waals TM2 P 263 2x40 G.H5 E 351 G.H5.22
Polar TM4 G 347 4x34 G.H5 N 348 G.H5.19
Hydrophobic TM5 M 431 5x76 G.H5 L 345 G.H5.16
Van-der-waals TM5 M 431 5x76 G.H5 L 345 G.H5.16
Hydrophobic TM2 Y 262 2x39 G.H5 E 351 G.H5.22
Van-der-waals TM2 Y 262 2x39 G.H5 E 351 G.H5.22
Hydrophobic ICL2 K 345 - G.H5 K 341 G.H5.12
Van-der-waals ICL2 K 345 - G.H5 K 341 G.H5.12
Polar TM4 A 350 4x37 G.hns1 R 33 G.hns1.02
Aromatic TM3 W 338 3x50 G.H5 F 352 G.H5.23
Hydrophobic TM3 W 338 3x50 G.H5 F 352 G.H5.23
Van-der-waals TM3 W 338 3x50 G.H5 F 352 G.H5.23
Van-der-waals ICL2 W 346 - G.H5 N 348 G.H5.19
Polar TM4 H 348 4x35 G.h3s5 N 262 G.h3s5.02
Hydrophobic TM4 H 348 4x35 G.h3s5 N 262 G.h3s5.02
Van-der-waals TM4 H 348 4x35 G.h3s5 N 262 G.h3s5.02
Hydrophobic TM6 K 447 6x32 G.H5 L 354 G.H5.25
Van-der-waals TM7 W 527 7x55 G.H5 F 352 G.H5.23
Polar TM3 A 341 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 341 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 341 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 T 337 3x49 G.H5 F 352 G.H5.23
Hydrophobic ICL2 K 345 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 K 345 - G.H5 I 344 G.H5.15
Hydrophobic TM6 L 444 6x29 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 444 6x29 G.H5 L 354 G.H5.25
Hydrophobic ICL3 K 440 - G.H5 L 349 G.H5.20
Hydrophobic ICL3 L 441 - G.H5 L 349 G.H5.20
Hydrophobic ICL3 L 441 - G.H5 L 345 G.H5.16
Polar ICL2 W 346 - G.hns1 R 33 G.hns1.02
Aromatic ICL2 W 346 - G.hns1 R 33 G.hns1.02
Hydrophobic ICL2 W 346 - G.hns1 R 33 G.hns1.02
Van-der-waals ICL2 W 346 - G.hns1 R 33 G.hns1.02
Hydrophobic TM6 I 448 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 I 448 6x33 G.H5 L 354 G.H5.25
Polar ICL1 R 259 12x49 G.H5 N 353 G.H5.24
Hydrophobic ICL1 R 259 12x49 G.H5 N 353 G.H5.24
Van-der-waals ICL1 R 259 12x49 G.H5 N 353 G.H5.24
Ionic TM4 H 348 4x35 G.H5 E 351 G.H5.22
Polar TM4 H 348 4x35 G.H5 E 351 G.H5.22
Hydrophobic TM4 H 348 4x35 G.H5 E 351 G.H5.22
Van-der-waals TM4 H 348 4x35 G.H5 E 351 G.H5.22
Polar TM2 E 264 2x41 G.H5 N 353 G.H5.24
Hydrophobic TM2 E 264 2x41 G.H5 N 353 G.H5.24
Van-der-waals TM2 E 264 2x41 G.H5 N 353 G.H5.24
Polar TM2 E 264 2x41 G.H5 E 351 G.H5.22
Hydrophobic TM2 E 264 2x41 G.H5 E 351 G.H5.22
Hydrophobic TM3 A 341 3x53 G.H5 F 352 G.H5.23
Van-der-waals TM3 A 341 3x53 G.H5 F 352 G.H5.23
Hydrophobic TM4 G 347 4x34 G.H5 E 351 G.H5.22
Van-der-waals TM4 G 347 4x34 G.H5 E 351 G.H5.22
Hydrophobic TM7 W 527 7x55 G.H5 L 354 G.H5.25
Van-der-waals TM7 W 527 7x55 G.H5 L 354 G.H5.25
Hydrophobic TM5 I 427 5x72 G.H5 L 345 G.H5.16
Van-der-waals TM5 I 427 5x72 G.H5 L 345 G.H5.16
Polar N-term Q 81 - G.h2s4 E 217 G.h2s4.02
Van-der-waals N-term Q 81 - G.h2s4 E 217 G.h2s4.02
Polar TM4 H 354 4x41 G.hns1 R 33 G.hns1.02
Aromatic TM4 H 354 4x41 G.hns1 R 33 G.hns1.02
Hydrophobic TM4 H 354 4x41 G.hns1 R 33 G.hns1.02
Van-der-waals TM4 H 354 4x41 G.hns1 R 33 G.hns1.02
Hydrophobic ICL1 Q 261 12x51 G.H5 E 351 G.H5.22
Van-der-waals ICL1 Q 261 12x51 G.H5 E 351 G.H5.22
Hydrophobic TM2 P 263 2x40 G.H5 F 352 G.H5.23
Van-der-waals TM2 P 263 2x40 G.H5 F 352 G.H5.23
Ionic H8 K 532 8x49 G.h4s6 E 317 G.h4s6.12
Polar H8 K 532 8x49 G.h4s6 E 317 G.h4s6.12
Van-der-waals H8 K 532 8x49 G.h4s6 E 317 G.h4s6.12
Polar TM6 K 447 6x32 G.H5 N 353 G.H5.24
Van-der-waals TM6 K 447 6x32 G.H5 N 353 G.H5.24
Hydrophobic TM6 L 444 6x29 G.H5 L 349 G.H5.20
Van-der-waals TM6 L 444 6x29 G.H5 L 349 G.H5.20
Van-der-waals ICL1 F 260 12x50 G.H5 N 353 G.H5.24
Hydrophobic TM2 E 264 2x41 G.H5 F 352 G.H5.23
Van-der-waals TM2 E 264 2x41 G.H5 F 352 G.H5.23
Hydrophobic TM4 H 348 4x35 G.H5 L 347 G.H5.18
Van-der-waals TM5 M 431 5x76 G.H5 D 342 G.H5.13