Gs - GHRH receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 T 234 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 T 234 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 T 234 - G.S1 H 41 G.S1.02
Polar TM6 S 330 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 330 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 330 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 231 3x58 G.H5 H 387 G.H5.19
Polar TM5 K 310 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 310 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 310 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 S 235 - G.S1 H 41 G.S1.02
Hydrophobic TM3 L 230 3x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 T 234 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 T 234 - G.H5 F 376 G.H5.08
Hydrophobic TM7 Y 376 7x57 G.H5 Y 391 G.H5.23
Hydrophobic H8 N 380 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 380 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 236 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 P 236 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 L 307 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM6 F 333 6x44 G.H5 L 393 G.H5.25
Polar TM3 L 231 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 231 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 231 3x58 G.H5 Q 384 G.H5.16
Polar TM5 K 310 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 310 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 310 5x64 G.H5 R 385 G.H5.17
Hydrophobic H8 R 403 8x70 G.H3 W 281 G.H3.17
Van-der-waals H8 R 403 8x70 G.H3 W 281 G.H3.17
Hydrophobic TM5 K 310 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 311 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 311 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 230 3x57 G.H5 Y 391 G.H5.23
Polar H8 T 404 8x71 G.H3 R 280 G.H3.16
Hydrophobic ICL2 P 236 - G.S1 H 41 G.S1.02
Polar H8 Q 381 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 Q 381 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM5 L 307 5x61 G.H5 L 393 G.H5.25
Polar TM2 R 161 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 161 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 161 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM3 L 227 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 227 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 231 3x58 G.H5 L 388 G.H5.20
Hydrophobic ICL2 S 237 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 S 237 - G.hns1 A 39 G.hns1.03
Polar TM6 R 326 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 326 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 326 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM2 H 165 2x50 G.H5 Y 391 G.H5.23
Van-der-waals TM2 H 165 2x50 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 337 6x48 G.H5 Y 391 G.H5.23
Hydrophobic C-term A 406 - G.H3 R 280 G.H3.16
Van-der-waals C-term A 406 - G.H3 R 280 G.H3.16
Hydrophobic TM6 L 334 6x45 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 307 5x61 G.H5 L 394 G.H5.26
Hydrophobic ICL3 Q 315 - G.S6 P 361 G.S6.03
Van-der-waals ICL3 Q 315 - G.S6 P 361 G.S6.03
Hydrophobic TM4 R 239 4x40 G.HN Q 35 G.HN.52
Hydrophobic TM3 L 227 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 236 - G.hns1 A 39 G.hns1.03
Ionic TM5 K 310 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 310 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 310 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 310 5x64 G.H5 D 381 G.H5.13
Hydrophobic ICL2 T 234 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 T 234 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 T 234 - G.H5 R 380 G.H5.12
Hydrophobic ICL3 Q 315 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 Q 315 - G.H4 L 346 G.H4.16
Aromatic TM2 R 161 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 161 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 161 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 226 3x53 G.H5 Y 391 G.H5.23
Polar ICL3 Q 315 - G.S6 C 359 G.S6.01
Hydrophobic ICL3 Q 315 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 Q 315 - G.S6 C 359 G.S6.01