Gt2 - GHRH receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 24.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 R 161 2x46 G.H5 G 352 G.H5.24
Van-der-waals TM2 R 161 2x46 G.H5 G 352 G.H5.24
Polar ICL2 S 235 - G.hns1 E 30 G.hns1.01
Hydrophobic ICL2 S 235 - G.hns1 E 30 G.hns1.01
Van-der-waals ICL2 S 235 - G.hns1 E 30 G.hns1.01
Hydrophobic H8 T 385 8x52 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 T 234 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 T 234 - G.hns1 A 31 G.hns1.02
Hydrophobic TM5 K 310 5x64 G.H5 L 348 G.H5.20
Polar TM3 S 233 3x60 G.HN A 27 G.HN.51
Van-der-waals TM3 S 233 3x60 G.HN A 27 G.HN.51
Polar ICL2 T 234 - G.HN D 28 G.HN.52
Van-der-waals ICL2 T 234 - G.HN D 28 G.HN.52
Polar ICL2 T 234 - G.HN K 29 G.HN.53
Hydrophobic ICL2 T 234 - G.HN K 29 G.HN.53
Van-der-waals ICL2 T 234 - G.HN K 29 G.HN.53
Polar ICL2 T 234 - G.S1 T 33 G.S1.01
Hydrophobic ICL2 T 234 - G.S1 T 33 G.S1.01
Van-der-waals ICL2 T 234 - G.S1 T 33 G.S1.01
Polar ICL2 S 237 - G.hns1 E 30 G.hns1.01
Hydrophobic TM3 L 230 3x57 G.hns1 K 32 G.hns1.03
Van-der-waals TM3 L 230 3x57 G.hns1 K 32 G.hns1.03
Polar TM7 Y 376 7x57 G.H5 G 352 G.H5.24
Hydrophobic TM7 Y 376 7x57 G.H5 G 352 G.H5.24
Van-der-waals TM7 Y 376 7x57 G.H5 G 352 G.H5.24
Hydrophobic TM2 R 161 2x46 G.H5 C 351 G.H5.23
Hydrophobic TM3 L 231 3x58 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 231 3x58 G.H5 L 348 G.H5.20
Hydrophobic ICL2 S 235 - G.S1 T 33 G.S1.01
Van-der-waals ICL2 S 235 - G.S1 T 33 G.S1.01
Polar H8 R 403 8x70 G.h4s6 L 310 G.h4s6.01
Hydrophobic H8 R 403 8x70 G.h4s6 L 310 G.h4s6.01
Van-der-waals H8 R 403 8x70 G.h4s6 L 310 G.h4s6.01
Hydrophobic C-term W 408 - G.hgh4 F 287 G.hgh4.02
Polar TM2 R 161 2x46 G.H5 K 349 G.H5.21
Van-der-waals TM2 R 161 2x46 G.H5 K 349 G.H5.21
Hydrophobic TM3 L 227 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM3 L 230 3x57 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 230 3x57 G.H5 C 351 G.H5.23
Polar ICL2 T 234 - G.S3 N 195 G.S3.02
Hydrophobic ICL2 T 234 - G.S3 N 195 G.S3.02
Van-der-waals ICL2 T 234 - G.S3 N 195 G.S3.02
Polar TM5 K 310 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM5 K 310 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 310 5x64 G.H5 I 344 G.H5.16
Polar ICL2 T 234 - G.hns1 E 30 G.hns1.01
Hydrophobic ICL2 T 234 - G.hns1 E 30 G.hns1.01
Van-der-waals ICL2 T 234 - G.hns1 E 30 G.hns1.01
Hydrophobic ICL2 T 234 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 T 234 - G.hns1 K 32 G.hns1.03
Polar TM6 S 330 6x41 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 330 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 307 5x61 G.H5 L 353 G.H5.25
Polar TM2 R 161 2x46 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 161 2x46 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 161 2x46 G.H5 D 350 G.H5.22
Polar ICL2 S 235 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 S 235 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 S 235 - G.hns1 K 32 G.hns1.03
Polar H8 Q 381 8x48 G.H5 K 349 G.H5.21
Van-der-waals H8 Q 381 8x48 G.H5 K 349 G.H5.21
Hydrophobic TM3 L 231 3x58 G.hns1 K 32 G.hns1.03
Van-der-waals TM3 L 231 3x58 G.hns1 K 32 G.hns1.03
Ionic C-term R 413 - G.s4h3 E 239 G.s4h3.13
Polar H8 R 403 8x70 G.H3 N 251 G.H3.10
Hydrophobic H8 R 403 8x70 G.H3 N 251 G.H3.10
Van-der-waals H8 R 403 8x70 G.H3 N 251 G.H3.10
Hydrophobic TM6 L 334 6x45 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 334 6x45 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 326 6x37 G.H5 F 354 G.H5.26
Hydrophobic H8 R 403 8x70 G.h4s6 M 312 G.h4s6.03
Van-der-waals H8 R 403 8x70 G.h4s6 M 312 G.h4s6.03
Polar TM3 S 233 3x60 G.hns1 K 32 G.hns1.03
Hydrophobic TM3 S 233 3x60 G.hns1 K 32 G.hns1.03
Van-der-waals TM3 S 233 3x60 G.hns1 K 32 G.hns1.03
Polar TM3 A 232 3x59 G.hns1 K 32 G.hns1.03
Hydrophobic TM3 A 232 3x59 G.hns1 K 32 G.hns1.03
Van-der-waals TM3 A 232 3x59 G.hns1 K 32 G.hns1.03
Aromatic TM6 K 329 6x40 G.H5 F 354 G.H5.26
Aromatic C-term W 408 - G.H3 H 244 G.H3.03
Hydrophobic C-term W 408 - G.H3 H 244 G.H3.03
Van-der-waals C-term W 408 - G.H3 H 244 G.H3.03
Hydrophobic TM5 I 303 5x57 G.H5 L 353 G.H5.25
Hydrophobic TM3 L 227 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 227 3x54 G.H5 C 351 G.H5.23
Polar ICL2 P 236 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 P 236 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 P 236 - G.hns1 A 31 G.hns1.02
Hydrophobic TM5 L 307 5x61 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 307 5x61 G.H5 L 348 G.H5.20
Polar ICL2 S 235 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 S 235 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 S 235 - G.hns1 A 31 G.hns1.02
Polar ICL2 T 234 - G.HN A 27 G.HN.51
Hydrophobic H8 T 385 8x52 G.h4s6 V 316 G.h4s6.10
Polar TM3 S 233 3x60 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 S 233 3x60 G.hns1 A 31 G.hns1.02
Van-der-waals TM3 S 233 3x60 G.hns1 A 31 G.hns1.02
Polar TM3 S 233 3x60 G.HN D 28 G.HN.52
Hydrophobic TM3 S 233 3x60 G.HN D 28 G.HN.52
Van-der-waals TM3 S 233 3x60 G.HN D 28 G.HN.52
Ionic TM5 R 309 5x63 G.s2s3 D 193 G.s2s3.02
Polar TM5 R 309 5x63 G.s2s3 D 193 G.s2s3.02
Van-der-waals TM5 R 309 5x63 G.s2s3 D 193 G.s2s3.02
Polar ICL2 P 236 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 P 236 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 P 236 - G.hns1 K 32 G.hns1.03