Gs - GPR101 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 84.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 226 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 L 226 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM3 I 133 3x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 137 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 137 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 P 140 34x54 G.hns1 A 39 G.hns1.03
Polar TM3 S 132 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 S 132 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 S 132 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL3 V 236 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 V 236 - G.H4 D 343 G.H4.13
Hydrophobic C-term P 485 - G.H3 R 280 G.H3.16
Van-der-waals C-term P 485 - G.H3 R 280 G.H3.16
Polar TM2 T 66 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 T 66 2x39 G.H5 Y 391 G.H5.23
Polar TM5 Q 222 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 222 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 222 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 137 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL3 S 233 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 S 233 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM6 V 400 6x36 G.H5 L 393 G.H5.25
Hydrophobic C-term L 487 - G.h2s4 F 238 G.h2s4.01
Hydrophobic ICL2 L 137 34x51 G.S3 V 217 G.S3.01
Ionic TM6 K 396 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 396 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 396 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 396 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 I 401 6x37 G.H5 L 393 G.H5.25
Polar TM4 Q 145 4x39 G.HN Q 35 G.HN.52
Hydrophobic TM5 L 226 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 L 226 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 Y 393 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 Y 393 6x29 G.H5 L 394 G.H5.26
Polar ICL3 R 381 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 R 381 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 A 218 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 137 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 137 34x51 G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 137 34x51 G.S3 F 219 G.S3.03
Hydrophobic ICL2 P 140 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 P 140 34x54 G.hns1 R 38 G.hns1.02
Polar ICL3 R 381 - G.h4s6 A 351 G.h4s6.04
Hydrophobic ICL3 R 381 - G.h4s6 A 351 G.h4s6.04
Van-der-waals ICL3 R 381 - G.h4s6 A 351 G.h4s6.04
Hydrophobic TM5 A 218 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 137 34x51 G.H5 C 379 G.H5.11
Polar H8 H 458 8x47 G.H5 Q 390 G.H5.22
Van-der-waals H8 H 458 8x47 G.H5 Q 390 G.H5.22
Ionic H8 K 459 8x48 G.H5 E 392 G.H5.24
Polar H8 K 459 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 459 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 459 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 136 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 136 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM7 M 457 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM5 Q 222 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 Q 222 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 133 3x54 G.H5 L 388 G.H5.20
Polar TM5 Q 222 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 Q 222 5x68 G.H5 D 381 G.H5.13
Hydrophobic ICL2 P 136 34x50 G.H5 Q 384 G.H5.16
Hydrophobic H8 H 458 8x47 G.H5 Y 391 G.H5.23
Van-der-waals H8 H 458 8x47 G.H5 Y 391 G.H5.23
Ionic ICL3 H 232 - G.H4 D 343 G.H4.13
Hydrophobic ICL3 H 232 - G.H4 D 343 G.H4.13
Polar TM3 S 132 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 132 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM4 T 144 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 T 144 4x38 G.HN Q 35 G.HN.52
Polar TM2 Q 64 2x37 G.H5 Q 390 G.H5.22
Hydrophobic TM5 Q 222 5x68 G.H5 L 394 G.H5.26
Hydrophobic ICL3 H 232 - G.hgh4 P 321 G.hgh4.11
Polar TM4 Q 145 4x39 G.HN Q 31 G.HN.48
Hydrophobic TM4 Q 145 4x39 G.HN Q 31 G.HN.48
Van-der-waals TM4 Q 145 4x39 G.HN Q 31 G.HN.48
Polar TM6 A 397 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 397 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 397 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL3 V 236 - G.H4 R 347 G.H4.17
Hydrophobic TM3 I 133 3x54 G.H5 Y 391 G.H5.23
Polar ICL2 P 140 34x54 G.HN Q 35 G.HN.52
Van-der-waals ICL2 P 140 34x54 G.HN Q 35 G.HN.52
Hydrophobic ICL2 P 136 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 136 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM3 I 133 3x54 G.H5 L 393 G.H5.25
Polar TM6 K 396 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 396 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 396 6x32 G.H5 L 394 G.H5.26
Hydrophobic ICL3 H 232 - G.H4 L 346 G.H4.16
Hydrophobic C-term L 487 - G.H2 R 232 G.H2.05
Hydrophobic C-term L 487 - G.H2 I 235 G.H2.08
Van-der-waals C-term L 487 - G.H2 I 235 G.H2.08
Hydrophobic TM6 V 400 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 V 400 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM3 R 129 3x50 G.H5 Y 391 G.H5.23
Polar TM3 I 133 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 133 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 133 3x54 G.H5 Q 384 G.H5.16
Polar ICL2 L 137 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 137 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 137 34x51 G.S1 H 41 G.S1.02
Polar ICL3 H 232 - G.H4 R 342 G.H4.12
Aromatic ICL3 H 232 - G.H4 R 342 G.H4.12
Hydrophobic ICL3 H 232 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 H 232 - G.H4 R 342 G.H4.12
Hydrophobic C-term P 485 - G.H3 W 281 G.H3.17
Van-der-waals C-term P 485 - G.H3 W 281 G.H3.17
Hydrophobic TM5 V 215 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 V 215 5x61 G.H5 L 393 G.H5.25
Ionic ICL3 H 232 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 H 232 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 H 232 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 H 232 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 S 141 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals C-term P 485 - G.H2 I 235 G.H2.08
Hydrophobic TM5 A 219 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 136 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM5 L 226 5x72 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 226 5x72 G.H5 L 394 G.H5.26
Polar TM5 Q 222 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 222 5x68 G.H5 R 385 G.H5.17
Hydrophobic H8 H 458 8x47 G.H5 E 392 G.H5.24