G11 - GPR107 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 72.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 27.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM4 K 365 4x41 G.H5 V 359 G.H5.26
Hydrophobic ICL2 H 360 - G.H5 L 358 G.H5.25
Hydrophobic C-term L 557 - G.HN K 33 G.HN.51
Hydrophobic TM2 K 293 2x37 G.hns1 R 38 G.hns1.03
Van-der-waals TM2 K 293 2x37 G.hns1 R 38 G.hns1.03
Hydrophobic TM3 G 354 3x53 G.H5 L 358 G.H5.25
Van-der-waals TM3 G 354 3x53 G.H5 L 358 G.H5.25
Polar TM5 H 425 5x60 G.H5 E 355 G.H5.22
Hydrophobic TM5 H 425 5x60 G.H5 E 355 G.H5.22
Van-der-waals TM5 H 425 5x60 G.H5 E 355 G.H5.22
Van-der-waals ICL3 F 459 - G.s4h3 E 245 G.s4h3.14
Hydrophobic TM5 L 426 5x61 G.H5 N 357 G.H5.24
Van-der-waals TM5 L 426 5x61 G.H5 N 357 G.H5.24
Hydrophobic ICL1 R 288 - G.HN R 30 G.HN.48
Van-der-waals ICL1 R 288 - G.HN R 30 G.HN.48
Polar TM3 G 354 3x53 G.H5 N 357 G.H5.24
Hydrophobic TM3 G 354 3x53 G.H5 N 357 G.H5.24
Van-der-waals TM3 G 354 3x53 G.H5 N 357 G.H5.24
Hydrophobic TM6 V 476 6x18 G.H3 P 262 G.H3.16
Hydrophobic ICL3 L 464 - G.H3 L 254 G.H3.08
Hydrophobic TM4 S 363 4x39 G.H5 Q 350 G.H5.17
Van-der-waals TM4 S 363 4x39 G.H5 Q 350 G.H5.17
Hydrophobic TM4 S 363 4x39 G.H5 V 359 G.H5.26
Van-der-waals TM4 S 363 4x39 G.H5 V 359 G.H5.26
Ionic TM6 R 479 6x21 G.h2s4 E 221 G.h2s4.02
Polar TM6 R 479 6x21 G.h2s4 E 221 G.h2s4.02
Hydrophobic TM4 S 363 4x39 G.H5 L 353 G.H5.20
Van-der-waals TM4 S 363 4x39 G.H5 L 353 G.H5.20
Polar ICL1 R 288 - G.HN R 34 G.HN.52
Hydrophobic ICL1 R 288 - G.HN R 34 G.HN.52
Van-der-waals ICL1 R 288 - G.HN R 34 G.HN.52
Polar TM5 D 433 5x68 G.h3s5 Q 265 G.h3s5.01
Hydrophobic TM5 D 433 5x68 G.h3s5 Q 265 G.h3s5.01
Van-der-waals TM5 D 433 5x68 G.h3s5 Q 265 G.h3s5.01
Hydrophobic ICL2 K 359 - G.H5 N 352 G.H5.19
Van-der-waals ICL2 K 359 - G.H5 N 352 G.H5.19
Hydrophobic TM6 F 494 6x36 G.H5 N 357 G.H5.24
Van-der-waals TM6 F 494 6x36 G.H5 N 357 G.H5.24
Hydrophobic ICL2 I 358 - G.H5 N 357 G.H5.24
Van-der-waals ICL2 I 358 - G.H5 N 357 G.H5.24
Van-der-waals TM5 L 426 5x61 G.H5 E 355 G.H5.22
Hydrophobic C-term L 557 - G.h2s4 N 222 G.h2s4.03
Polar TM5 T 432 5x67 G.h4s6 D 319 G.h4s6.10
Hydrophobic TM5 T 432 5x67 G.h4s6 D 319 G.h4s6.10
Van-der-waals TM5 T 432 5x67 G.h4s6 D 319 G.h4s6.10
Ionic ICL1 D 290 - G.HN K 33 G.HN.51
Polar ICL1 D 290 - G.HN K 33 G.HN.51
Hydrophobic ICL1 D 290 - G.HN K 33 G.HN.51
Van-der-waals ICL1 D 290 - G.HN K 33 G.HN.51
Hydrophobic TM3 L 350 3x49 G.H5 L 358 G.H5.25
Ionic ICL1 D 290 - G.hns1 R 37 G.hns1.02
Polar ICL1 D 290 - G.hns1 R 37 G.hns1.02
Hydrophobic ICL1 D 290 - G.hns1 R 37 G.hns1.02
Van-der-waals ICL1 D 290 - G.hns1 R 37 G.hns1.02
Hydrophobic ICL3 L 467 - G.H2 I 217 G.H2.08
Hydrophobic ICL2 I 361 - G.H5 L 349 G.H5.16
Van-der-waals ICL2 I 361 - G.H5 L 349 G.H5.16
Polar ICL1 V 291 - G.HN R 34 G.HN.52
Hydrophobic ICL1 V 291 - G.HN R 34 G.HN.52
Van-der-waals ICL1 V 291 - G.HN R 34 G.HN.52
Polar TM6 N 487 6x29 G.h3s5 N 266 G.h3s5.02
Hydrophobic TM6 N 487 6x29 G.h3s5 N 266 G.h3s5.02
Van-der-waals TM6 N 487 6x29 G.h3s5 N 266 G.h3s5.02
Polar TM5 T 432 5x67 G.h3s5 Q 265 G.h3s5.01
Polar C-term L 555 - G.hns1 R 37 G.hns1.02
Hydrophobic C-term L 555 - G.hns1 R 37 G.hns1.02
Van-der-waals C-term L 555 - G.hns1 R 37 G.hns1.02
Van-der-waals TM5 A 429 5x64 G.h3s5 N 266 G.h3s5.02
Hydrophobic ICL3 C 471 - G.H2 I 217 G.H2.08
Hydrophobic ICL2 I 361 - G.H5 L 358 G.H5.25
Van-der-waals ICL2 I 361 - G.H5 L 358 G.H5.25
Polar ICL1 N 289 - G.HN E 26 G.HN.44
Hydrophobic ICL1 N 289 - G.HN E 26 G.HN.44
Van-der-waals ICL1 N 289 - G.HN E 26 G.HN.44
Van-der-waals TM6 T 483 6x25 G.h3s5 N 266 G.h3s5.02
Polar C-term S 550 - G.HN K 33 G.HN.51
Polar ICL2 H 360 - G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 H 360 - G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 H 360 - G.hns1 R 37 G.hns1.02
Polar ICL2 K 359 - G.H5 K 354 G.H5.21
Hydrophobic ICL2 K 359 - G.H5 K 354 G.H5.21
Van-der-waals ICL2 K 359 - G.H5 K 354 G.H5.21
Polar TM4 D 366 4x42 G.H5 V 359 G.H5.26
Hydrophobic TM4 D 366 4x42 G.H5 V 359 G.H5.26
Van-der-waals TM4 D 366 4x42 G.H5 V 359 G.H5.26
Hydrophobic ICL3 L 467 - G.H2 R 214 G.H2.05
Van-der-waals ICL3 L 467 - G.H2 R 214 G.H2.05
Hydrophobic ICL3 L 467 - G.H2 R 213 G.H2.04
Polar C-term Q 559 - G.HN K 33 G.HN.51
Hydrophobic C-term Q 559 - G.HN K 33 G.HN.51
Van-der-waals C-term Q 559 - G.HN K 33 G.HN.51
Hydrophobic ICL3 A 460 - G.H3 A 253 G.H3.07
Hydrophobic ICL2 L 362 - G.H5 L 358 G.H5.25
Polar TM5 D 433 5x68 G.h3s5 N 266 G.h3s5.02
Polar TM4 D 364 4x40 G.H5 Q 350 G.H5.17
Hydrophobic TM4 D 364 4x40 G.H5 Q 350 G.H5.17
Van-der-waals TM4 D 364 4x40 G.H5 Q 350 G.H5.17
Hydrophobic C-term E 560 - G.h2s4 E 221 G.h2s4.02
Van-der-waals C-term E 560 - G.h2s4 E 221 G.h2s4.02
Hydrophobic ICL2 H 360 - G.hns1 R 38 G.hns1.03
Polar C-term S 558 - G.h2s4 N 222 G.h2s4.03
Van-der-waals C-term S 558 - G.h2s4 N 222 G.h2s4.03
Polar TM5 S 422 5x57 G.H5 N 357 G.H5.24
Hydrophobic TM5 S 422 5x57 G.H5 N 357 G.H5.24
Van-der-waals TM5 S 422 5x57 G.H5 N 357 G.H5.24
Ionic ICL3 D 463 - G.H2 R 214 G.H2.05
Polar ICL3 D 463 - G.H2 R 214 G.H2.05
Van-der-waals ICL3 D 463 - G.H2 R 214 G.H2.05
Polar TM3 T 353 3x52 G.H5 L 358 G.H5.25
Hydrophobic TM3 T 353 3x52 G.H5 L 358 G.H5.25
Van-der-waals TM3 T 353 3x52 G.H5 L 358 G.H5.25
Hydrophobic ICL2 L 362 - G.H5 V 359 G.H5.26
Hydrophobic ICL2 L 362 - G.H5 L 353 G.H5.20
Van-der-waals ICL2 L 362 - G.H5 L 353 G.H5.20
Polar ICL2 K 359 - G.H5 N 357 G.H5.24
Hydrophobic ICL2 K 359 - G.H5 N 357 G.H5.24
Van-der-waals ICL2 K 359 - G.H5 N 357 G.H5.24
Hydrophobic ICL2 I 361 - G.H5 L 353 G.H5.20
Van-der-waals ICL2 I 361 - G.H5 L 353 G.H5.20
Polar ICL2 K 359 - G.H5 L 353 G.H5.20
Hydrophobic ICL2 K 359 - G.H5 L 353 G.H5.20
Van-der-waals ICL2 K 359 - G.H5 L 353 G.H5.20
Hydrophobic TM3 G 354 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 G 354 3x53 G.H5 Y 356 G.H5.23
Polar ICL2 K 359 - G.H5 V 359 G.H5.26
Hydrophobic ICL2 K 359 - G.H5 V 359 G.H5.26
Van-der-waals ICL2 K 359 - G.H5 V 359 G.H5.26
Hydrophobic ICL2 W 355 - G.H5 L 358 G.H5.25
Van-der-waals ICL2 W 355 - G.H5 L 358 G.H5.25
Hydrophobic ICL1 N 289 - G.HN L 29 G.HN.47
Van-der-waals ICL1 N 289 - G.HN L 29 G.HN.47
Hydrophobic TM1 R 287 1x60 G.HN R 30 G.HN.48
Van-der-waals TM1 R 287 1x60 G.HN R 30 G.HN.48
Polar TM1 K 286 1x59 G.HN R 30 G.HN.48
Hydrophobic TM1 K 286 1x59 G.HN R 30 G.HN.48
Van-der-waals TM1 K 286 1x59 G.HN R 30 G.HN.48
Hydrophobic ICL3 L 464 - G.H3 T 257 G.H3.11
Hydrophobic TM6 R 479 6x21 G.H3 W 263 G.H3.17
Van-der-waals TM6 R 479 6x21 G.H3 W 263 G.H3.17
Hydrophobic C-term E 560 - G.H3 W 263 G.H3.17
Van-der-waals C-term E 560 - G.H3 W 263 G.H3.17
Hydrophobic ICL2 K 359 - G.H5 L 358 G.H5.25
Van-der-waals ICL2 K 359 - G.H5 L 358 G.H5.25
Polar ICL2 K 359 - G.H5 Y 356 G.H5.23
Hydrophobic ICL2 K 359 - G.H5 Y 356 G.H5.23
Van-der-waals ICL2 K 359 - G.H5 Y 356 G.H5.23
Hydrophobic TM3 T 353 3x52 G.H5 N 357 G.H5.24
Van-der-waals TM3 T 353 3x52 G.H5 N 357 G.H5.24
Hydrophobic TM5 W 421 5x56 G.H5 V 359 G.H5.26
Van-der-waals TM5 W 421 5x56 G.H5 V 359 G.H5.26
Hydrophobic TM4 D 366 4x42 G.H5 L 358 G.H5.25
Van-der-waals TM4 D 366 4x42 G.H5 L 358 G.H5.25
Hydrophobic ICL2 H 360 - G.H5 L 353 G.H5.20
Van-der-waals ICL2 H 360 - G.H5 L 353 G.H5.20
Polar TM5 H 425 5x60 G.H5 K 354 G.H5.21
Hydrophobic TM5 H 425 5x60 G.H5 K 354 G.H5.21
Van-der-waals TM5 H 425 5x60 G.H5 K 354 G.H5.21
Polar ICL1 N 289 - G.HN R 34 G.HN.52
Hydrophobic ICL1 N 289 - G.HN R 34 G.HN.52
Van-der-waals ICL1 N 289 - G.HN R 34 G.HN.52
Hydrophobic ICL2 H 360 - G.S3 I 199 G.S3.01
Polar C-term L 555 - G.HN K 33 G.HN.51
Van-der-waals C-term L 555 - G.HN K 33 G.HN.51
Hydrophobic ICL2 K 359 - G.H5 E 355 G.H5.22
Aromatic TM2 F 292 2x36 G.hns1 R 37 G.hns1.02
Hydrophobic TM2 F 292 2x36 G.hns1 R 37 G.hns1.02
Van-der-waals TM2 F 292 2x36 G.hns1 R 37 G.hns1.02
Polar ICL3 L 464 - G.H3 Y 261 G.H3.15
Hydrophobic ICL3 L 464 - G.H3 Y 261 G.H3.15
Van-der-waals ICL3 L 464 - G.H3 Y 261 G.H3.15
Hydrophobic ICL2 I 361 - G.S3 I 199 G.S3.01
Van-der-waals ICL2 I 361 - G.S3 I 199 G.S3.01
Hydrophobic ICL2 I 358 - G.H5 Y 356 G.H5.23
Van-der-waals ICL2 I 358 - G.H5 Y 356 G.H5.23
Polar ICL1 N 289 - G.HN R 30 G.HN.48
Hydrophobic ICL1 N 289 - G.HN R 30 G.HN.48
Van-der-waals ICL1 N 289 - G.HN R 30 G.HN.48