G12 - GPR119 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 83.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 H 195 5x69 G.H5 L 371 G.H5.16
Aromatic ICL2 F 111 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 111 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 111 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM6 A 223 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 110 34x50 G.H5 K 367 G.H5.12
Polar TM5 Q 198 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 Q 198 5x72 G.H5 D 368 G.H5.13
Polar ICL2 M 117 34x57 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 M 117 34x57 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 M 117 34x57 G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 A 209 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 A 209 - G.H4 R 329 G.H4.09
Polar TM6 K 222 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 222 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 222 6x32 G.H5 Q 381 G.H5.26
Polar ICL1 D 37 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL1 D 37 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 D 37 - G.hns1 R 55 G.hns1.02
Hydrophobic TM2 G 38 2x37 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 G 38 2x37 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 L 114 34x54 G.H5 I 370 G.H5.15
Polar ICL2 K 115 34x55 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 K 115 34x55 G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 F 111 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 111 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM6 P 215 6x25 G.h4s6 S 343 G.h4s6.12
Polar ICL2 L 114 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 L 114 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 L 114 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 F 111 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 111 34x51 G.H5 I 370 G.H5.15
Polar TM3 R 103 3x50 G.H5 D 377 G.H5.22
Hydrophobic TM5 I 199 5x73 G.h4s6 P 345 G.h4s6.20
Hydrophobic H8 Q 283 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 111 34x51 G.H5 V 366 G.H5.11
Polar TM3 A 106 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 106 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 106 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 I 199 5x73 G.H5 Q 372 G.H5.17
Van-der-waals TM5 I 199 5x73 G.H5 Q 372 G.H5.17
Hydrophobic TM6 K 222 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM5 A 192 5x66 G.H5 L 375 G.H5.20
Van-der-waals TM5 A 192 5x66 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 110 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 110 34x50 G.H5 I 370 G.H5.15
Ionic ICL1 D 37 - G.HN R 52 G.HN.52
Polar ICL1 D 37 - G.HN R 52 G.HN.52
Hydrophobic ICL1 D 37 - G.HN R 52 G.HN.52
Van-der-waals ICL1 D 37 - G.HN R 52 G.HN.52
Hydrophobic TM6 P 215 6x25 G.h4s6 R 342 G.h4s6.11
Van-der-waals TM6 P 215 6x25 G.h4s6 R 342 G.h4s6.11
Hydrophobic TM3 I 107 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 107 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM6 L 230 6x40 G.H5 L 380 G.H5.25
Hydrophobic TM6 T 226 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM7 W 282 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 W 282 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 107 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 107 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 103 3x50 G.H5 L 380 G.H5.25
Van-der-waals TM3 R 103 3x50 G.H5 L 380 G.H5.25
Polar TM5 H 195 5x69 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 195 5x69 G.H5 D 368 G.H5.13
Hydrophobic TM3 R 103 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM5 M 202 5x76 G.S6 F 347 G.S6.02
Polar ICL3 A 209 - G.H4 Q 333 G.H4.13
Hydrophobic ICL3 A 209 - G.H4 Q 333 G.H4.13
Van-der-waals ICL3 A 209 - G.H4 Q 333 G.H4.13
Aromatic ICL3 Y 212 - G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL2 F 111 34x51 G.S1 V 58 G.S1.02
Polar TM4 S 118 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic TM4 S 118 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 S 118 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 M 188 5x62 G.H5 I 378 G.H5.23
Van-der-waals TM5 M 188 5x62 G.H5 I 378 G.H5.23
Hydrophobic TM3 I 107 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM3 I 107 3x54 G.H5 N 374 G.H5.19
Hydrophobic TM5 H 195 5x69 G.H5 L 375 G.H5.20
Hydrophobic TM6 T 226 6x36 G.H5 I 378 G.H5.23
Van-der-waals TM6 T 226 6x36 G.H5 I 378 G.H5.23
Hydrophobic H8 K 284 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 284 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM6 T 226 6x36 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 111 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 111 34x51 G.S3 I 221 G.S3.01
Polar ICL2 K 115 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 K 115 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 K 115 34x55 G.hns1 R 56 G.hns1.03
Polar ICL2 I 116 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 I 116 34x56 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 I 116 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 F 111 34x51 G.S3 F 223 G.S3.03
Hydrophobic TM5 H 195 5x69 G.H5 Q 372 G.H5.17
Van-der-waals TM5 H 195 5x69 G.H5 Q 372 G.H5.17
Van-der-waals ICL2 L 114 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 I 191 5x65 G.H5 L 371 G.H5.16