Gi3 - GPR139 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic H8 S 289 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 T 138 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 T 138 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL3 R 219 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 219 - G.h4s6 E 318 G.h4s6.12
Polar ICL2 P 133 34x50 G.H5 N 347 G.H5.19
Ionic ICL2 K 135 34x52 G.s2s3 D 193 G.s2s3.02
Polar ICL2 K 135 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 K 135 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 K 135 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL3 F 216 - G.H5 I 344 G.H5.16
Ionic H8 K 290 8x48 G.h4s6 D 315 G.h4s6.09
Ionic ICL3 R 219 - G.H5 D 341 G.H5.13
Polar ICL3 R 219 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 219 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 H 137 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 H 137 34x54 G.hns1 A 31 G.hns1.02
Ionic ICL2 H 137 34x54 G.H5 E 350 G.H5.22
Hydrophobic ICL2 H 137 34x54 G.H5 E 350 G.H5.22
Polar ICL3 R 219 - G.S6 H 322 G.S6.04
Hydrophobic ICL3 R 219 - G.S6 H 322 G.S6.04
Van-der-waals ICL3 R 219 - G.S6 H 322 G.S6.04
Hydrophobic TM5 L 210 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 230 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 230 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL3 F 216 - G.H5 L 348 G.H5.20
Ionic TM2 K 60 2x37 G.H5 E 350 G.H5.22
Polar TM2 K 60 2x37 G.H5 E 350 G.H5.22
Hydrophobic TM2 K 60 2x37 G.H5 E 350 G.H5.22
Van-der-waals TM2 K 60 2x37 G.H5 E 350 G.H5.22
Hydrophobic ICL2 L 134 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM2 S 62 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 133 34x50 G.H5 I 343 G.H5.15
Van-der-waals TM5 K 213 5x68 G.H5 T 340 G.H5.12
Hydrophobic ICL2 L 134 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 134 34x51 G.S3 L 194 G.S3.01
Ionic TM5 K 213 5x68 G.H5 D 341 G.H5.13
Polar TM5 K 213 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 133 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM5 K 213 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 213 5x68 G.H5 I 344 G.H5.16
Polar TM2 S 62 2x39 G.H5 E 350 G.H5.22
Hydrophobic TM2 S 62 2x39 G.H5 E 350 G.H5.22
Van-der-waals TM2 S 62 2x39 G.H5 E 350 G.H5.22
Hydrophobic ICL2 L 134 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 L 134 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM5 L 210 5x65 G.H5 L 348 G.H5.20
Van-der-waals ICL3 N 215 - G.H5 D 341 G.H5.13
Polar ICL3 R 219 - G.H5 F 334 G.H5.06
Polar TM6 Y 221 6x28 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 Y 221 6x28 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 Y 221 6x28 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 R 126 3x50 G.H5 L 353 G.H5.25
Polar ICL3 R 219 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 R 219 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 R 219 - G.H5 D 337 G.H5.09
Hydrophobic C-term I 321 - G.H2 I 212 G.H2.08
Van-der-waals C-term I 321 - G.H2 I 212 G.H2.08
Hydrophobic C-term F 319 - G.H2 I 212 G.H2.08
Hydrophobic ICL2 L 134 34x51 G.H5 I 343 G.H5.15
Hydrophobic C-term M 337 - G.H1 V 50 G.H1.05
Polar TM6 T 226 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 226 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 226 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL3 R 219 - G.H5 A 338 G.H5.10
Van-der-waals ICL3 R 219 - G.H5 A 338 G.H5.10
Polar ICL2 H 137 34x54 G.H5 N 347 G.H5.19
Hydrophobic C-term V 339 - G.hfs2 V 179 G.hfs2.03
Van-der-waals C-term V 339 - G.hfs2 V 179 G.hfs2.03
Polar TM6 K 225 6x32 G.H5 Y 354 G.H5.26
Aromatic TM6 K 225 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 225 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 225 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM4 Y 141 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 Y 141 4x38 G.HN E 28 G.HN.52
Hydrophobic C-term F 319 - G.H3 W 258 G.H3.17
Van-der-waals C-term F 319 - G.H3 W 258 G.H3.17
Polar TM3 R 126 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 126 3x50 G.H5 C 351 G.H5.23
Polar ICL3 F 216 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 F 216 - G.H5 D 341 G.H5.13
Hydrophobic TM6 Y 221 6x28 G.H5 K 345 G.H5.17
Van-der-waals TM6 Y 221 6x28 G.H5 K 345 G.H5.17
Hydrophobic TM4 A 143 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 A 143 4x40 G.HN R 24 G.HN.48
Hydrophobic TM3 V 130 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 130 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 134 34x51 G.H5 F 336 G.H5.08
Van-der-waals H8 K 290 8x48 G.h4s6 T 316 G.h4s6.10
Hydrophobic C-term I 335 - G.S2 E 186 G.S2.03
Van-der-waals C-term I 335 - G.S2 E 186 G.S2.03
Polar ICL2 Y 136 34x53 G.H5 E 350 G.H5.22
Hydrophobic ICL2 Y 136 34x53 G.H5 E 350 G.H5.22
Hydrophobic ICL2 P 133 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 133 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 T 226 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 I 229 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 229 6x36 G.H5 L 353 G.H5.25
Aromatic TM6 Y 221 6x28 G.H5 Y 354 G.H5.26
Hydrophobic TM6 Y 221 6x28 G.H5 Y 354 G.H5.26
Van-der-waals TM6 Y 221 6x28 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 Y 136 34x53 G.H5 N 347 G.H5.19
Polar TM6 G 220 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 G 220 6x27 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 G 220 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 A 129 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 129 3x53 G.H5 C 351 G.H5.23
Polar C-term Y 342 - G.hfs2 T 182 G.hfs2.06
Hydrophobic C-term Y 342 - G.hfs2 T 182 G.hfs2.06
Van-der-waals C-term Y 342 - G.hfs2 T 182 G.hfs2.06
Hydrophobic ICL3 R 219 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 219 - G.S6 Y 320 G.S6.02
Polar ICL2 Y 136 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 136 34x53 G.H5 C 351 G.H5.23
Van-der-waals C-term I 321 - G.H2 K 209 G.H2.05
Polar TM3 A 129 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 129 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 129 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 Y 221 6x28 G.H5 L 348 G.H5.20
Van-der-waals TM6 Y 221 6x28 G.H5 L 348 G.H5.20