Gs - GPR139 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 133 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 133 34x50 G.H5 H 387 G.H5.19
Hydrophobic C-term W 326 - G.hns1 R 38 G.hns1.02
Van-der-waals C-term W 326 - G.hns1 R 38 G.hns1.02
Hydrophobic TM6 I 229 6x36 G.H5 L 393 G.H5.25
Hydrophobic C-term M 337 - G.H2 I 235 G.H2.08
Aromatic ICL2 H 137 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 H 137 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 H 137 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 L 210 5x65 G.H5 Q 384 G.H5.16
Van-der-waals TM5 L 210 5x65 G.H5 Q 384 G.H5.16
Hydrophobic TM6 T 226 6x33 G.H5 L 388 G.H5.20
Hydrophobic TM3 R 126 3x50 G.H5 L 393 G.H5.25
Hydrophobic C-term M 337 - G.H2 Q 236 G.H2.09
Van-der-waals C-term M 337 - G.H2 Q 236 G.H2.09
Hydrophobic ICL2 P 133 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 133 34x50 G.H5 R 380 G.H5.12
Polar TM6 Y 221 6x28 G.H5 L 394 G.H5.26
Hydrophobic TM6 Y 221 6x28 G.H5 L 394 G.H5.26
Van-der-waals TM6 Y 221 6x28 G.H5 L 394 G.H5.26
Polar C-term T 322 - G.h3s5 T 284 G.h3s5.02
Hydrophobic C-term T 322 - G.h3s5 T 284 G.h3s5.02
Van-der-waals C-term T 322 - G.h3s5 T 284 G.h3s5.02
Polar TM5 K 213 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 213 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 213 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 F 216 - G.H5 L 394 G.H5.26
Hydrophobic TM3 V 130 3x54 G.H5 L 393 G.H5.25
Aromatic C-term W 326 - G.HN K 34 G.HN.51
Hydrophobic C-term W 326 - G.HN K 34 G.HN.51
Van-der-waals C-term W 326 - G.HN K 34 G.HN.51
Polar TM6 T 226 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 226 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 226 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 134 34x51 G.S3 V 217 G.S3.01
Polar ICL3 R 219 - G.S6 C 359 G.S6.01
Hydrophobic ICL3 R 219 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 R 219 - G.S6 C 359 G.S6.01
Polar H8 S 289 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 S 289 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 289 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 122 3x46 G.H5 Y 391 G.H5.23
Polar H8 K 290 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 290 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM6 I 229 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 I 229 6x36 G.H5 E 392 G.H5.24
Hydrophobic ICL3 F 216 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 F 216 - G.H5 D 381 G.H5.13
Polar ICL1 Q 59 12x53 G.hns1 R 38 G.hns1.02
Hydrophobic ICL1 Q 59 12x53 G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 Q 59 12x53 G.hns1 R 38 G.hns1.02
Aromatic ICL3 F 216 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 F 216 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 F 216 - G.H5 R 385 G.H5.17
Polar TM6 K 225 6x32 G.H5 E 392 G.H5.24
Polar TM2 S 62 2x39 G.H5 Q 390 G.H5.22
Van-der-waals TM2 S 62 2x39 G.H5 Q 390 G.H5.22
Hydrophobic TM3 V 130 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 130 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 K 135 34x52 G.S3 V 217 G.S3.01
Polar ICL1 R 58 12x52 G.hns1 R 38 G.hns1.02
Hydrophobic C-term P 325 - G.h2s4 D 240 G.h2s4.03
Polar ICL3 R 219 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 R 219 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 R 219 - G.H5 R 385 G.H5.17
Polar H8 R 291 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM2 S 62 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 S 62 2x39 G.H5 Y 391 G.H5.23
Polar ICL2 K 135 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 K 135 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 K 135 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 L 134 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 134 34x51 G.H5 F 376 G.H5.08
Hydrophobic C-term P 325 - G.hns1 R 38 G.hns1.02
Van-der-waals C-term P 325 - G.hns1 R 38 G.hns1.02
Hydrophobic TM6 L 230 6x37 G.H5 L 393 G.H5.25
Hydrophobic C-term I 321 - G.H3 W 281 G.H3.17
Van-der-waals C-term I 321 - G.H3 W 281 G.H3.17
Hydrophobic ICL2 T 138 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 T 138 34x55 G.hns1 A 39 G.hns1.03
Aromatic ICL3 R 219 - G.S6 Y 360 G.S6.02
Hydrophobic ICL3 R 219 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 R 219 - G.S6 Y 360 G.S6.02
Polar ICL2 Y 136 34x53 G.H5 Q 390 G.H5.22
Polar TM3 R 126 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 Y 391 G.H5.23
Polar ICL1 Q 59 12x53 G.HN K 34 G.HN.51
Hydrophobic ICL1 Q 59 12x53 G.HN K 34 G.HN.51
Van-der-waals ICL1 Q 59 12x53 G.HN K 34 G.HN.51
Polar TM4 Y 141 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM4 Y 141 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 Y 141 4x38 G.HN Q 35 G.HN.52
Polar TM6 Y 221 6x28 G.H5 L 393 G.H5.25
Van-der-waals TM6 Y 221 6x28 G.H5 L 393 G.H5.25
Polar ICL2 L 134 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 134 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 134 34x51 G.S1 H 41 G.S1.02
Polar ICL2 Y 136 34x53 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 Y 136 34x53 G.H5 Y 391 G.H5.23
Polar TM3 D 125 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 125 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 125 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 A 129 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 129 3x53 G.H5 Y 391 G.H5.23
Polar TM3 A 129 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 129 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 129 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 133 34x50 G.H5 Q 384 G.H5.16
Polar TM3 V 130 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 130 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 130 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 H 137 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 L 134 34x51 G.H5 C 379 G.H5.11
Hydrophobic ICL2 P 133 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM7 I 288 7x56 G.H5 E 392 G.H5.24
Hydrophobic ICL3 F 216 - G.H5 L 388 G.H5.20
Van-der-waals ICL3 F 216 - G.H5 L 388 G.H5.20
Polar TM2 K 60 2x37 G.H5 Q 390 G.H5.22
Hydrophobic TM2 K 60 2x37 G.H5 Q 390 G.H5.22
Van-der-waals TM2 K 60 2x37 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 L 134 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM6 K 225 6x32 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 134 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 134 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM5 L 210 5x65 G.H5 L 388 G.H5.20
Ionic ICL3 R 219 - G.H5 D 378 G.H5.10
Polar TM6 K 225 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 225 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 225 6x32 G.H5 L 394 G.H5.26
Aromatic ICL2 Y 136 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 136 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 Y 136 34x53 G.H5 H 387 G.H5.19