Gq - GPR141 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 23.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 109 3x46 G.H5 V 359 G.H5.26
Van-der-waals TM3 I 109 3x46 G.H5 V 359 G.H5.26
Van-der-waals ICL2 C 120 34x50 G.HN K 33 G.HN.51
Hydrophobic TM5 K 210 5x64 G.hns1 R 38 G.hns1.03
Van-der-waals TM5 K 210 5x64 G.hns1 R 38 G.hns1.03
Hydrophobic TM6 A 223 6x33 G.H5 Y 356 G.H5.23
Ionic TM6 E 220 6x30 G.hns1 R 38 G.hns1.03
Polar TM6 E 220 6x30 G.hns1 R 38 G.hns1.03
Hydrophobic TM6 E 220 6x30 G.hns1 R 38 G.hns1.03
Van-der-waals TM6 E 220 6x30 G.hns1 R 38 G.hns1.03
Hydrophobic TM6 F 230 6x40 G.H5 V 359 G.H5.26
Van-der-waals TM6 F 230 6x40 G.H5 V 359 G.H5.26
Polar ICL3 S 217 - G.s2s3 Q 197 G.s2s3.01
Van-der-waals ICL3 S 217 - G.s2s3 Q 197 G.s2s3.01
Polar ICL3 H 218 - G.s2s3 Q 197 G.s2s3.01
Hydrophobic ICL3 H 218 - G.s2s3 Q 197 G.s2s3.01
Van-der-waals ICL3 H 218 - G.s2s3 Q 197 G.s2s3.01
Polar TM3 K 119 3x56 G.hns1 R 37 G.hns1.02
Van-der-waals TM3 K 119 3x56 G.hns1 R 37 G.hns1.02
Polar ICL1 R 48 12x51 G.h3s5 N 266 G.h3s5.02
Van-der-waals ICL1 R 48 12x51 G.h3s5 N 266 G.h3s5.02
Hydrophobic TM2 V 55 2x43 G.H5 V 359 G.H5.26
Van-der-waals TM2 V 55 2x43 G.H5 V 359 G.H5.26
Hydrophobic TM6 Q 219 6x29 G.H5 L 353 G.H5.20
Van-der-waals TM6 Q 219 6x29 G.H5 L 353 G.H5.20
Hydrophobic TM1 L 41 1x57 G.H5 L 358 G.H5.25
Hydrophobic TM6 K 226 6x36 G.H5 V 359 G.H5.26
Van-der-waals TM6 K 226 6x36 G.H5 V 359 G.H5.26
Ionic H8 H 289 8x48 G.H5 D 346 G.H5.13
Polar TM6 K 226 6x36 G.H5 N 357 G.H5.24
Hydrophobic TM6 K 226 6x36 G.H5 N 357 G.H5.24
Van-der-waals TM6 K 226 6x36 G.H5 N 357 G.H5.24
Polar ICL1 N 46 12x49 G.H5 E 355 G.H5.22
Van-der-waals ICL1 N 46 12x49 G.H5 E 355 G.H5.22
Polar H8 K 292 8x51 G.H5 N 357 G.H5.24
Hydrophobic H8 K 292 8x51 G.H5 N 357 G.H5.24
Van-der-waals H8 K 292 8x51 G.H5 N 357 G.H5.24
Polar ICL2 D 122 34x52 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 D 122 34x52 G.H5 Y 356 G.H5.23
Hydrophobic TM3 K 119 3x56 G.HN R 34 G.HN.52
Polar TM3 R 113 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 113 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 113 3x50 G.H5 Y 356 G.H5.23
Ionic ICL2 K 123 34x53 G.H5 E 355 G.H5.22
Polar ICL2 K 123 34x53 G.H5 E 355 G.H5.22
Hydrophobic ICL2 K 123 34x53 G.H5 E 355 G.H5.22
Van-der-waals ICL2 K 123 34x53 G.H5 E 355 G.H5.22
Polar H8 H 289 8x48 G.H5 Q 350 G.H5.17
Hydrophobic H8 H 289 8x48 G.H5 Q 350 G.H5.17
Van-der-waals H8 H 289 8x48 G.H5 Q 350 G.H5.17
Polar ICL3 S 214 - G.s2s3 Q 197 G.s2s3.01
Hydrophobic ICL3 S 214 - G.s2s3 Q 197 G.s2s3.01
Van-der-waals ICL3 S 214 - G.s2s3 Q 197 G.s2s3.01
Hydrophobic TM2 T 51 2x39 G.H5 V 359 G.H5.26
Van-der-waals TM2 T 51 2x39 G.H5 V 359 G.H5.26
Hydrophobic ICL2 K 121 34x51 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 K 121 34x51 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 D 122 34x52 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 D 122 34x52 G.hns1 R 37 G.hns1.02
Polar TM3 R 113 3x50 G.H5 V 359 G.H5.26
Hydrophobic TM3 R 113 3x50 G.H5 V 359 G.H5.26
Van-der-waals TM3 R 113 3x50 G.H5 V 359 G.H5.26
Van-der-waals ICL2 E 125 34x55 G.H5 E 355 G.H5.22
Polar ICL2 C 120 34x50 G.HN R 34 G.HN.52
Hydrophobic ICL2 C 120 34x50 G.HN R 34 G.HN.52
Van-der-waals ICL2 C 120 34x50 G.HN R 34 G.HN.52
Hydrophobic TM6 Q 219 6x29 G.H5 L 349 G.H5.16
Van-der-waals TM6 Q 219 6x29 G.H5 L 349 G.H5.16
Polar TM3 F 118 3x55 G.HN R 34 G.HN.52
Hydrophobic TM3 F 118 3x55 G.HN R 34 G.HN.52
Van-der-waals TM3 F 118 3x55 G.HN R 34 G.HN.52
Hydrophobic TM7 F 283 7x53 G.H5 V 359 G.H5.26
Van-der-waals TM7 F 283 7x53 G.H5 V 359 G.H5.26
Hydrophobic TM3 I 116 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 I 116 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM7 F 283 7x53 G.H5 L 358 G.H5.25
Van-der-waals TM7 F 283 7x53 G.H5 L 358 G.H5.25
Polar ICL4 G 287 - G.H5 N 357 G.H5.24
Polar ICL2 C 120 34x50 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 C 120 34x50 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 C 120 34x50 G.hns1 R 37 G.hns1.02
Polar ICL3 H 218 - G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL3 H 218 - G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL3 H 218 - G.s2s3 S 198 G.s2s3.02
Polar ICL3 S 217 - G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL3 S 217 - G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL3 S 217 - G.s2s3 S 198 G.s2s3.02
Polar TM2 S 49 2x37 G.H5 E 355 G.H5.22
Hydrophobic TM2 S 49 2x37 G.H5 E 355 G.H5.22
Hydrophobic ICL1 M 45 12x48 G.H5 L 358 G.H5.25
Van-der-waals ICL1 M 45 12x48 G.H5 L 358 G.H5.25
Polar TM6 Q 219 6x29 G.H5 Q 350 G.H5.17