Gs - GPR141 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 24.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 K 123 34x53 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 K 123 34x53 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 K 123 34x53 G.hns1 R 38 G.hns1.02
Hydrophobic TM6 Q 219 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 Q 219 6x29 G.H5 L 394 G.H5.26
Polar ICL2 C 120 34x50 G.HN Q 35 G.HN.52
Hydrophobic ICL2 C 120 34x50 G.HN Q 35 G.HN.52
Van-der-waals ICL2 C 120 34x50 G.HN Q 35 G.HN.52
Polar ICL1 N 46 12x49 G.H5 E 392 G.H5.24
Hydrophobic ICL1 N 46 12x49 G.H5 E 392 G.H5.24
Van-der-waals ICL1 N 46 12x49 G.H5 E 392 G.H5.24
Hydrophobic H8 K 292 8x51 G.H5 L 394 G.H5.26
Van-der-waals H8 K 292 8x51 G.H5 L 394 G.H5.26
Polar TM2 S 49 2x37 G.H5 E 392 G.H5.24
Hydrophobic TM2 S 49 2x37 G.H5 E 392 G.H5.24
Van-der-waals TM2 S 49 2x37 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 116 3x53 G.H5 L 393 G.H5.25
Hydrophobic TM6 E 220 6x30 G.H5 L 388 G.H5.20
Polar TM3 K 119 3x56 G.s2s3 K 216 G.s2s3.02
Van-der-waals TM3 K 119 3x56 G.s2s3 K 216 G.s2s3.02
Polar TM2 T 52 2x40 G.H5 E 392 G.H5.24
Hydrophobic TM2 T 52 2x40 G.H5 E 392 G.H5.24
Van-der-waals TM2 T 52 2x40 G.H5 E 392 G.H5.24
Ionic ICL3 H 218 - G.H5 D 381 G.H5.13
Polar ICL3 H 218 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 H 218 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 H 218 - G.H5 D 381 G.H5.13
Hydrophobic ICL2 D 122 34x52 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 D 122 34x52 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 124 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 K 121 34x51 G.HN Q 35 G.HN.52
Van-der-waals ICL2 K 121 34x51 G.HN Q 35 G.HN.52
Polar ICL2 Y 127 34x57 G.HN K 34 G.HN.51
Aromatic ICL2 Y 127 34x57 G.HN K 34 G.HN.51
Hydrophobic ICL2 Y 127 34x57 G.HN K 34 G.HN.51
Van-der-waals ICL2 Y 127 34x57 G.HN K 34 G.HN.51
Polar ICL2 D 122 34x52 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 D 122 34x52 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 D 122 34x52 G.hns1 R 38 G.hns1.02
Polar TM3 R 113 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM3 R 113 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM3 R 113 3x50 G.H5 L 393 G.H5.25
Polar ICL3 S 217 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 S 217 - G.H5 R 385 G.H5.17
Hydrophobic TM2 T 51 2x39 G.H5 L 393 G.H5.25
Polar ICL2 K 121 34x51 G.HN Q 31 G.HN.48
Hydrophobic ICL2 K 121 34x51 G.HN Q 31 G.HN.48
Van-der-waals ICL2 K 121 34x51 G.HN Q 31 G.HN.48
Hydrophobic TM2 T 51 2x39 G.H5 E 392 G.H5.24
Van-der-waals TM2 T 51 2x39 G.H5 E 392 G.H5.24
Polar TM5 K 210 5x64 G.s2s3 D 215 G.s2s3.01
Van-der-waals TM5 K 210 5x64 G.s2s3 D 215 G.s2s3.01
Polar ICL2 E 125 34x55 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 E 125 34x55 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 E 125 34x55 G.hns1 R 38 G.hns1.02
Hydrophobic ICL1 M 45 12x48 G.H5 E 392 G.H5.24
Polar ICL2 D 122 34x52 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 D 122 34x52 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 D 122 34x52 G.hns1 A 39 G.hns1.03
Polar ICL2 D 122 34x52 G.hns1 Y 37 G.hns1.01
Polar TM6 E 220 6x30 G.H5 Q 384 G.H5.16
Hydrophobic TM6 E 220 6x30 G.H5 Q 384 G.H5.16
Van-der-waals TM6 E 220 6x30 G.H5 Q 384 G.H5.16
Polar ICL1 N 46 12x49 G.H5 Q 390 G.H5.22
Polar ICL1 T 47 12x50 G.H5 E 392 G.H5.24
Van-der-waals ICL1 M 45 12x48 G.H5 L 394 G.H5.26
Hydrophobic ICL2 K 123 34x53 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 K 123 34x53 G.H5 Y 391 G.H5.23
Polar ICL2 K 123 34x53 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 D 122 34x52 G.HN Q 35 G.HN.52
Van-der-waals ICL2 D 122 34x52 G.HN Q 35 G.HN.52
Polar ICL2 D 122 34x52 G.HN V 36 G.HN.53
Hydrophobic ICL2 D 122 34x52 G.HN V 36 G.HN.53
Van-der-waals ICL2 D 122 34x52 G.HN V 36 G.HN.53
Hydrophobic TM6 Q 219 6x29 G.H5 L 388 G.H5.20
Hydrophobic TM6 Q 219 6x29 G.H5 R 385 G.H5.17
Van-der-waals TM6 Q 219 6x29 G.H5 R 385 G.H5.17
Hydrophobic TM6 K 226 6x36 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 226 6x36 G.H5 L 394 G.H5.26