Ggust - GPR141 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 24.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 K 226 6x36 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 226 6x36 G.H5 F 354 G.H5.26
Polar TM2 T 52 2x40 G.H5 G 352 G.H5.24
Hydrophobic TM2 T 51 2x39 G.H5 G 352 G.H5.24
Polar TM2 T 52 2x40 G.H5 D 350 G.H5.22
Ionic ICL2 D 122 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 D 122 34x52 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 122 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 D 122 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL4 G 287 - G.H5 F 354 G.H5.26
Van-der-waals ICL4 G 287 - G.H5 F 354 G.H5.26
Hydrophobic ICL1 M 45 12x48 G.H5 G 352 G.H5.24
Van-der-waals ICL1 M 45 12x48 G.H5 G 352 G.H5.24
Polar H8 H 289 8x48 G.H5 K 345 G.H5.17
Hydrophobic H8 H 289 8x48 G.H5 K 345 G.H5.17
Van-der-waals H8 H 289 8x48 G.H5 K 345 G.H5.17
Polar ICL2 K 123 34x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 K 123 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 K 123 34x53 G.H5 N 347 G.H5.19
Hydrophobic H8 K 292 8x51 G.H5 F 354 G.H5.26
Van-der-waals H8 K 292 8x51 G.H5 F 354 G.H5.26
Hydrophobic H8 K 292 8x51 G.H5 K 345 G.H5.17
Van-der-waals H8 K 292 8x51 G.H5 K 345 G.H5.17
Ionic ICL2 K 123 34x53 G.H5 D 350 G.H5.22
Van-der-waals ICL4 G 287 - G.H5 K 349 G.H5.21
Polar ICL2 Y 127 34x57 G.HN E 28 G.HN.52
Hydrophobic ICL2 Y 127 34x57 G.HN E 28 G.HN.52
Van-der-waals ICL2 Y 127 34x57 G.HN E 28 G.HN.52
Ionic H8 H 289 8x48 G.h4s6 E 318 G.h4s6.12
Polar H8 H 289 8x48 G.h4s6 E 318 G.h4s6.12
Hydrophobic H8 H 289 8x48 G.h4s6 E 318 G.h4s6.12
Van-der-waals H8 H 289 8x48 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 K 121 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 121 34x51 G.hns1 R 32 G.hns1.03
Ionic TM1 K 44 1x60 G.h4s6 D 316 G.h4s6.10
Polar TM1 K 44 1x60 G.h4s6 D 316 G.h4s6.10
Van-der-waals TM1 K 44 1x60 G.h4s6 D 316 G.h4s6.10
Polar TM6 K 226 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 226 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 K 226 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL1 M 45 12x48 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 51 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 51 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 W 222 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 W 222 6x32 G.H5 F 354 G.H5.26
Polar TM3 R 113 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 113 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 113 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 K 123 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 K 123 34x53 G.H5 C 351 G.H5.23
Ionic ICL3 H 218 - G.H5 D 341 G.H5.13
Polar ICL3 H 218 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 H 218 - G.H5 D 341 G.H5.13
Hydrophobic TM2 T 51 2x39 G.H5 L 353 G.H5.25
Van-der-waals TM2 T 51 2x39 G.H5 L 353 G.H5.25
Hydrophobic TM6 Q 219 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 Q 219 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 Y 127 34x57 G.HN A 27 G.HN.51
Van-der-waals ICL2 Y 127 34x57 G.HN A 27 G.HN.51
Hydrophobic TM6 A 223 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 223 6x33 G.H5 F 354 G.H5.26
Polar ICL1 N 46 12x49 G.H5 D 350 G.H5.22
Van-der-waals ICL1 N 46 12x49 G.H5 D 350 G.H5.22
Polar ICL2 D 122 34x52 G.S3 L 194 G.S3.01
Hydrophobic ICL2 D 122 34x52 G.S3 L 194 G.S3.01
Van-der-waals ICL2 D 122 34x52 G.S3 L 194 G.S3.01
Polar TM6 Q 219 6x29 G.H5 D 341 G.H5.13
Hydrophobic TM6 Q 219 6x29 G.H5 D 341 G.H5.13
Van-der-waals TM6 Q 219 6x29 G.H5 D 341 G.H5.13
Hydrophobic TM6 Q 219 6x29 G.H5 I 342 G.H5.14
Van-der-waals TM6 Q 219 6x29 G.H5 I 342 G.H5.14
Polar ICL2 Y 127 34x57 G.HN Q 24 G.HN.48
Hydrophobic ICL2 Y 127 34x57 G.HN Q 24 G.HN.48
Van-der-waals ICL2 Y 127 34x57 G.HN Q 24 G.HN.48
Polar ICL2 C 120 34x50 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 C 120 34x50 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 C 120 34x50 G.s2s3 D 193 G.s2s3.02
Ionic ICL2 K 121 34x51 G.HN E 28 G.HN.52
Polar ICL2 K 121 34x51 G.HN E 28 G.HN.52
Van-der-waals ICL2 K 121 34x51 G.HN E 28 G.HN.52
Polar TM2 T 52 2x40 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 52 2x40 G.H5 C 351 G.H5.23
Polar TM6 Q 219 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 Q 219 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 Q 219 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM7 F 283 7x53 G.H5 G 352 G.H5.24
Polar TM2 S 49 2x37 G.H5 C 351 G.H5.23
Hydrophobic TM2 S 49 2x37 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 49 2x37 G.H5 C 351 G.H5.23
Hydrophobic ICL2 K 123 34x53 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 K 123 34x53 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 E 125 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 Y 127 34x57 G.HN L 23 G.HN.47
Van-der-waals ICL2 Y 127 34x57 G.HN L 23 G.HN.47
Hydrophobic TM6 A 223 6x33 G.H5 L 348 G.H5.20