Gi3 - GPR142 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 73.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 11.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 K 354 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 354 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 354 6x32 G.H5 Y 354 G.H5.26
Polar TM2 S 192 2x39 G.H5 E 350 G.H5.22
Hydrophobic TM2 S 192 2x39 G.H5 E 350 G.H5.22
Van-der-waals TM2 S 192 2x39 G.H5 E 350 G.H5.22
Polar TM3 R 256 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 256 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 256 3x50 G.H5 C 351 G.H5.23
Ionic TM6 R 351 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 351 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 351 6x29 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 351 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 L 260 3x54 G.H5 I 344 G.H5.16
Aromatic N-term W 14 - G.H3 W 258 G.H3.17
Hydrophobic N-term W 14 - G.H3 W 258 G.H3.17
Van-der-waals N-term W 14 - G.H3 W 258 G.H3.17
Polar ICL3 R 343 - G.H5 T 340 G.H5.12
Hydrophobic ICL3 R 343 - G.H5 T 340 G.H5.12
Van-der-waals ICL3 R 343 - G.H5 T 340 G.H5.12
Ionic ICL3 R 343 - G.H5 D 337 G.H5.09
Polar ICL3 R 343 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 R 343 - G.H5 D 337 G.H5.09
Hydrophobic ICL2 A 268 34x55 G.S3 L 194 G.S3.01
Van-der-waals ICL2 A 268 34x55 G.S3 L 194 G.S3.01
Hydrophobic ICL2 R 267 34x54 G.S1 V 34 G.S1.02
Polar N-term Y 31 - G.s4h3 E 236 G.s4h3.10
Hydrophobic N-term Y 31 - G.s4h3 E 236 G.s4h3.10
Van-der-waals N-term Y 31 - G.s4h3 E 236 G.s4h3.10
Ionic TM2 R 190 2x37 G.H5 E 350 G.H5.22
Polar TM2 R 190 2x37 G.H5 E 350 G.H5.22
Hydrophobic TM2 R 190 2x37 G.H5 E 350 G.H5.22
Van-der-waals TM2 R 190 2x37 G.H5 E 350 G.H5.22
Ionic N-term D 35 - G.hfs2 K 180 G.hfs2.04
Polar N-term D 35 - G.hfs2 K 180 G.hfs2.04
Van-der-waals N-term D 35 - G.hfs2 K 180 G.hfs2.04
Ionic ICL2 H 265 34x52 G.s2s3 D 193 G.s2s3.02
Polar ICL2 H 265 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 H 265 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic N-term V 25 - G.H3 S 252 G.H3.11
Hydrophobic ICL2 P 263 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 263 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 S 355 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM7 V 417 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 V 417 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM5 L 340 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 263 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 263 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM6 L 348 6x26 G.H5 I 344 G.H5.16
Polar TM6 S 355 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 355 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 259 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 348 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 L 348 6x26 G.H5 D 341 G.H5.13
Polar ICL2 R 267 34x54 G.S1 E 33 G.S1.01
Hydrophobic ICL2 R 267 34x54 G.S1 E 33 G.S1.01
Van-der-waals ICL2 R 267 34x54 G.S1 E 33 G.S1.01
Hydrophobic N-term L 19 - G.H2 I 212 G.H2.08
Hydrophobic ICL2 L 264 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 264 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 264 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 L 264 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic N-term Y 31 - G.s3h2 Q 204 G.s3h2.03
Ionic N-term E 29 - G.H2 R 205 G.H2.01
Polar N-term E 29 - G.H2 R 205 G.H2.01
Hydrophobic N-term E 29 - G.H2 R 205 G.H2.01
Van-der-waals N-term E 29 - G.H2 R 205 G.H2.01
Hydrophobic TM3 L 260 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 L 260 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM6 I 358 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 358 6x36 G.H5 L 353 G.H5.25
Polar TM4 P 272 4x40 G.HN E 28 G.HN.52
Hydrophobic TM4 P 272 4x40 G.HN E 28 G.HN.52
Hydrophobic TM6 L 348 6x26 G.S6 Y 320 G.S6.02
Van-der-waals TM6 L 348 6x26 G.S6 Y 320 G.S6.02
Polar TM4 S 271 4x39 G.HN E 28 G.HN.52
Hydrophobic TM4 S 271 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 S 271 4x39 G.HN E 28 G.HN.52
Hydrophobic ICL2 P 263 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM3 L 260 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 260 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 340 5x65 G.H5 I 344 G.H5.16
Polar ICL1 R 189 - G.HN L 23 G.HN.47
Van-der-waals ICL1 R 189 - G.HN L 23 G.HN.47
Polar N-term G 27 - G.H2 K 209 G.H2.05
Van-der-waals N-term G 27 - G.H2 K 209 G.H2.05
Hydrophobic ICL2 A 268 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 A 268 34x55 G.s2s3 D 193 G.s2s3.02
Polar TM6 R 351 6x29 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 351 6x29 G.h4s6 D 315 G.h4s6.09
Polar TM6 R 351 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 351 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 351 6x29 G.H5 Y 354 G.H5.26
Ionic ICL3 R 343 - G.H5 D 341 G.H5.13
Polar ICL3 R 343 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 343 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 343 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 L 264 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM6 L 359 6x37 G.H5 L 353 G.H5.25
Hydrophobic N-term I 22 - G.H3 N 256 G.H3.15
Van-der-waals N-term I 22 - G.H3 N 256 G.H3.15
Hydrophobic ICL3 R 343 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 R 343 - G.H5 I 344 G.H5.16
Hydrophobic TM3 L 260 3x54 G.H5 N 347 G.H5.19
Polar N-term L 26 - G.H2 K 209 G.H2.05
Hydrophobic N-term L 26 - G.H2 K 209 G.H2.05
Van-der-waals N-term L 26 - G.H2 K 209 G.H2.05
Polar N-term Y 31 - G.H2 S 206 G.H2.02
Hydrophobic N-term Y 31 - G.H2 S 206 G.H2.02
Van-der-waals N-term Y 31 - G.H2 S 206 G.H2.02
Hydrophobic ICL2 L 264 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 264 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 L 264 34x51 G.S2 F 191 G.S2.08
Hydrophobic N-term L 26 - G.H2 R 208 G.H2.04
Van-der-waals N-term L 26 - G.H2 R 208 G.H2.04
Polar ICL2 R 267 34x54 G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL2 R 267 34x54 G.h2s4 T 219 G.h2s4.05
Van-der-waals ICL2 R 267 34x54 G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL2 L 264 34x51 G.H5 T 340 G.H5.12
Polar ICL2 R 267 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 267 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 267 34x54 G.hns1 A 31 G.hns1.02
Polar N-term Y 31 - G.H2 R 205 G.H2.01
Hydrophobic N-term Y 31 - G.H2 R 205 G.H2.01
Van-der-waals N-term Y 31 - G.H2 R 205 G.H2.01
Polar ICL2 A 268 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 A 268 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 A 268 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic N-term L 26 - G.H3 L 249 G.H3.08
Hydrophobic ICL2 R 267 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 R 267 34x54 G.S3 L 194 G.S3.01
Polar TM3 A 259 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 259 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 259 3x53 G.H5 N 347 G.H5.19
Polar TM4 G 273 4x41 G.HN E 28 G.HN.52
Van-der-waals TM4 G 273 4x41 G.HN E 28 G.HN.52
Hydrophobic N-term W 14 - G.H2 I 212 G.H2.08