Golf - GPR146 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 79.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 A 132 3x55 G.h4s6 K 343 G.h4s6.12
Polar ICL2 R 135 - G.h2s4 F 225 G.h2s4.01
Van-der-waals ICL2 R 135 - G.h2s4 F 225 G.h2s4.01
Hydrophobic ICL2 P 134 - G.H3 R 267 G.H3.16
Van-der-waals ICL2 P 134 - G.H3 R 267 G.H3.16
Polar ICL3 D 221 - G.H3 W 268 G.H3.17
Van-der-waals ICL3 D 221 - G.H3 W 268 G.H3.17
Hydrophobic C-term A 333 - G.H2 Q 223 G.H2.09
Van-der-waals C-term A 333 - G.H2 Q 223 G.H2.09
Ionic TM5 D 217 5x68 G.H3 R 267 G.H3.16
Hydrophobic TM5 D 217 5x68 G.H3 R 267 G.H3.16
Van-der-waals TM5 D 217 5x68 G.H3 R 267 G.H3.16
Polar ICL3 T 218 - G.H3 N 266 G.H3.15
Hydrophobic ICL3 T 218 - G.H3 N 266 G.H3.15
Polar TM6 T 224 6x26 G.H3 W 268 G.H3.17
Polar ICL2 R 135 - G.H3 W 268 G.H3.17
Hydrophobic ICL2 Y 137 - G.H5 Q 377 G.H5.22
Van-der-waals ICL2 Y 137 - G.H5 Q 377 G.H5.22
Hydrophobic TM3 L 133 3x56 G.h4s6 K 343 G.h4s6.12
Van-der-waals TM3 L 133 3x56 G.h4s6 K 343 G.h4s6.12
Polar ICL2 R 135 - G.h3s5 T 271 G.h3s5.02
Hydrophobic ICL2 R 135 - G.h3s5 T 271 G.h3s5.02
Van-der-waals ICL2 R 135 - G.h3s5 T 271 G.h3s5.02
Ionic TM5 E 216 5x67 G.h3s5 R 270 G.h3s5.01
Polar TM5 E 216 5x67 G.h3s5 R 270 G.h3s5.01
Van-der-waals TM5 E 216 5x67 G.h3s5 R 270 G.h3s5.01
Polar ICL3 L 220 - G.H3 N 266 G.H3.15
Hydrophobic ICL3 L 220 - G.H3 N 266 G.H3.15
Van-der-waals ICL3 L 220 - G.H3 N 266 G.H3.15
Hydrophobic TM6 T 224 6x26 G.H2 I 222 G.H2.08
Van-der-waals TM6 T 224 6x26 G.H2 I 222 G.H2.08
Hydrophobic ICL3 L 220 - G.H3 S 262 G.H3.11
Van-der-waals ICL3 L 220 - G.H3 S 262 G.H3.11
Hydrophobic TM6 E 228 6x30 G.H3 W 268 G.H3.17
Van-der-waals TM6 E 228 6x30 G.H3 W 268 G.H3.17
Aromatic ICL2 Y 137 - G.H5 Y 378 G.H5.23
Hydrophobic ICL2 Y 137 - G.H5 Y 378 G.H5.23
Van-der-waals ICL2 Y 137 - G.H5 Y 378 G.H5.23
Polar ICL3 T 218 - G.H3 S 262 G.H3.11
Hydrophobic ICL2 R 135 - G.h3s5 I 272 G.h3s5.03
Van-der-waals ICL2 R 135 - G.h3s5 I 272 G.h3s5.03
Hydrophobic ICL3 L 220 - G.H2 W 221 G.H2.07
Hydrophobic TM3 R 131 3x54 G.H3 R 267 G.H3.16
Van-der-waals TM3 R 131 3x54 G.H3 R 267 G.H3.16
Ionic TM6 E 228 6x30 G.H3 R 267 G.H3.16
Polar TM6 E 228 6x30 G.H3 R 267 G.H3.16
Van-der-waals TM6 E 228 6x30 G.H3 R 267 G.H3.16
Hydrophobic ICL3 T 218 - G.H3 N 265 G.H3.14
Van-der-waals ICL3 T 218 - G.H3 N 265 G.H3.14
Polar ICL2 Y 137 - G.H5 E 379 G.H5.24
Hydrophobic ICL2 Y 137 - G.H5 E 379 G.H5.24
Hydrophobic ICL2 R 135 - G.H3 L 269 G.H3.18
Van-der-waals ICL2 R 135 - G.H3 L 269 G.H3.18
Hydrophobic ICL3 L 220 - G.H3 I 263 G.H3.12
Van-der-waals ICL3 L 220 - G.H3 I 263 G.H3.12
Van-der-waals TM6 G 225 6x27 G.H3 R 267 G.H3.16
Ionic ICL3 D 221 - G.H3 R 267 G.H3.16
Polar ICL3 D 221 - G.H3 R 267 G.H3.16
Hydrophobic ICL3 D 221 - G.H3 R 267 G.H3.16
Van-der-waals ICL3 D 221 - G.H3 R 267 G.H3.16
Polar ICL3 D 221 - G.H3 N 266 G.H3.15
Hydrophobic ICL3 D 221 - G.H3 N 266 G.H3.15
Van-der-waals ICL3 D 221 - G.H3 N 266 G.H3.15
Polar ICL2 M 138 - G.H5 E 379 G.H5.24
Hydrophobic ICL2 P 134 - G.H3 W 268 G.H3.17
Van-der-waals ICL2 P 134 - G.H3 W 268 G.H3.17
Hydrophobic TM3 L 133 3x56 G.h3s5 T 271 G.h3s5.02
Van-der-waals TM3 L 133 3x56 G.h3s5 T 271 G.h3s5.02
Hydrophobic ICL3 L 220 - G.h2s4 F 225 G.h2s4.01
Hydrophobic TM6 T 224 6x26 G.h2s4 F 225 G.h2s4.01
Polar ICL2 R 135 - G.h2s4 V 228 G.h2s4.04
Hydrophobic ICL2 R 135 - G.h2s4 V 228 G.h2s4.04
Van-der-waals ICL2 R 135 - G.h2s4 V 228 G.h2s4.04