G11 - GPR150 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR150 59.7
subunit alpha-11 87.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 15.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 285 6x25 G.H5 L 353 G.H5.20
Van-der-waals TM6 A 285 6x25 G.H5 L 353 G.H5.20
Hydrophobic C-term W 398 - G.hgh4 P 293 G.hgh4.03
Hydrophobic TM6 A 285 6x25 G.H5 Q 350 G.H5.17
Van-der-waals TM6 A 285 6x25 G.H5 Q 350 G.H5.17
Polar TM4 R 157 4x38 G.hns1 R 37 G.hns1.02
Hydrophobic TM4 R 157 4x38 G.hns1 R 37 G.hns1.02
Van-der-waals TM4 R 157 4x38 G.hns1 R 37 G.hns1.02
Polar TM4 R 157 4x38 G.HN R 34 G.HN.52
Hydrophobic TM4 R 157 4x38 G.HN R 34 G.HN.52
Van-der-waals TM4 R 157 4x38 G.HN R 34 G.HN.52
Polar ICL2 P 154 - G.H5 N 352 G.H5.19
Van-der-waals ICL2 P 154 - G.H5 N 352 G.H5.19
Hydrophobic TM3 V 151 3x54 G.H5 L 358 G.H5.25
Hydrophobic TM6 L 286 6x26 G.H5 L 353 G.H5.20
Hydrophobic TM2 R 80 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 R 80 2x37 G.H5 E 355 G.H5.22
Polar TM3 R 147 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 A 150 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 150 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL3 S 276 - G.H4 E 307 G.H4.09
Van-der-waals ICL3 S 276 - G.H4 E 307 G.H4.09
Polar TM2 R 80 2x37 G.H5 N 357 G.H5.24
Hydrophobic TM2 R 80 2x37 G.H5 N 357 G.H5.24
Van-der-waals TM2 R 80 2x37 G.H5 N 357 G.H5.24
Polar TM3 E 146 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 E 146 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 E 146 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM6 S 293 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 S 293 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM3 A 150 3x53 G.H5 L 358 G.H5.25
Hydrophobic TM6 L 286 6x26 G.H5 L 349 G.H5.16
Van-der-waals TM6 L 286 6x26 G.H5 L 349 G.H5.16
Polar TM2 K 81 2x38 G.H5 E 355 G.H5.22
Hydrophobic TM2 K 81 2x38 G.H5 E 355 G.H5.22
Van-der-waals TM2 K 81 2x38 G.H5 E 355 G.H5.22
Polar TM2 D 83 2x40 G.H5 N 357 G.H5.24
Van-der-waals TM2 D 83 2x40 G.H5 N 357 G.H5.24
Hydrophobic TM2 M 82 2x39 G.H5 N 357 G.H5.24
Van-der-waals TM2 M 82 2x39 G.H5 N 357 G.H5.24
Hydrophobic TM6 A 289 6x29 G.H5 V 359 G.H5.26
Polar TM2 M 82 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM2 M 82 2x39 G.H5 E 355 G.H5.22
Van-der-waals TM2 M 82 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM4 P 158 4x39 G.H5 Y 356 G.H5.23
Van-der-waals TM4 P 158 4x39 G.H5 Y 356 G.H5.23
Polar TM6 Q 292 6x32 G.H5 N 357 G.H5.24
Hydrophobic TM5 W 273 5x79 G.H5 F 339 G.H5.06
Van-der-waals TM5 W 273 5x79 G.H5 F 339 G.H5.06
Hydrophobic ICL1 W 74 - G.H3 P 262 G.H3.16
Hydrophobic ICL2 H 155 - G.H5 I 348 G.H5.15
Polar ICL2 G 156 - G.H5 N 352 G.H5.19
Polar ICL3 P 277 - G.H4 E 307 G.H4.09
Hydrophobic ICL3 P 277 - G.H4 E 307 G.H4.09
Van-der-waals ICL3 P 277 - G.H4 E 307 G.H4.09
Hydrophobic TM4 R 157 4x38 G.hns1 R 38 G.hns1.03
Van-der-waals TM4 R 157 4x38 G.hns1 R 38 G.hns1.03
Hydrophobic TM6 A 289 6x29 G.H5 L 353 G.H5.20
Van-der-waals TM6 A 289 6x29 G.H5 L 353 G.H5.20
Polar TM2 K 81 2x38 G.H5 Y 356 G.H5.23
Hydrophobic TM2 K 81 2x38 G.H5 Y 356 G.H5.23
Van-der-waals TM2 K 81 2x38 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 H 155 - G.H5 L 349 G.H5.16
Polar TM5 S 274 5x80 G.H4 R 306 G.H4.08
Polar ICL2 H 155 - G.H5 K 345 G.H5.12
Hydrophobic ICL2 H 155 - G.H5 K 345 G.H5.12
Van-der-waals ICL2 H 155 - G.H5 K 345 G.H5.12
Hydrophobic ICL3 S 276 - G.S6 F 328 G.S6.05
Van-der-waals ICL3 S 276 - G.S6 F 328 G.S6.05
Polar TM2 R 80 2x37 G.H5 K 354 G.H5.21
Hydrophobic TM2 R 80 2x37 G.H5 K 354 G.H5.21
Van-der-waals TM2 R 80 2x37 G.H5 K 354 G.H5.21
Polar TM2 R 80 2x37 G.H5 V 359 G.H5.26
Hydrophobic ICL2 P 154 - G.H5 L 349 G.H5.16
Van-der-waals ICL2 P 154 - G.H5 L 349 G.H5.16
Hydrophobic TM4 P 158 4x39 G.H5 E 355 G.H5.22
Hydrophobic ICL3 G 278 - G.H4 L 310 G.H4.12
Van-der-waals ICL3 G 278 - G.H4 L 310 G.H4.12
Polar TM6 A 289 6x29 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 289 6x29 G.H5 L 358 G.H5.25
Van-der-waals TM6 A 289 6x29 G.H5 L 358 G.H5.25
Hydrophobic TM6 Q 292 6x32 G.H5 L 358 G.H5.25
Hydrophobic TM2 M 82 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 M 82 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 147 3x50 G.H5 L 358 G.H5.25
Polar ICL3 R 279 - G.h4s6 K 322 G.h4s6.13
Aromatic TM5 W 273 5x79 G.S6 H 327 G.S6.04
Hydrophobic TM5 W 273 5x79 G.S6 H 327 G.S6.04
Van-der-waals TM5 W 273 5x79 G.S6 H 327 G.S6.04
Polar TM3 R 147 3x50 G.H5 N 357 G.H5.24
Hydrophobic ICL3 R 279 - G.H4 V 314 G.H4.16
Hydrophobic TM6 A 285 6x25 G.H5 V 359 G.H5.26
Van-der-waals TM6 A 285 6x25 G.H5 V 359 G.H5.26
Hydrophobic ICL3 A 282 - G.h4s6 I 323 G.h4s6.20
Van-der-waals ICL3 A 282 - G.h4s6 I 323 G.h4s6.20
Hydrophobic H8 Q 356 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 Q 356 8x47 G.H5 N 357 G.H5.24