G12 - GPR150 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 69.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 P 277 - G.H4 L 324 G.H4.04
Hydrophobic ICL1 G 76 - G.H5 D 377 G.H5.22
Hydrophobic TM5 W 273 5x79 G.H4 E 325 G.H4.05
Van-der-waals TM5 W 273 5x79 G.H4 E 325 G.H4.05
Hydrophobic TM6 K 290 6x30 G.H5 L 375 G.H5.20
Van-der-waals TM6 K 290 6x30 G.H5 L 375 G.H5.20
Hydrophobic TM6 S 293 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 293 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 H 155 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 H 155 - G.H5 I 370 G.H5.15
Hydrophobic ICL1 P 77 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 P 77 - G.hns1 R 55 G.hns1.02
Polar ICL1 R 79 - G.H5 D 377 G.H5.22
Hydrophobic ICL1 R 79 - G.H5 D 377 G.H5.22
Van-der-waals ICL1 R 79 - G.H5 D 377 G.H5.22
Hydrophobic TM5 W 273 5x79 G.H4 R 323 G.H4.03
Van-der-waals TM5 W 273 5x79 G.H4 R 323 G.H4.03
Hydrophobic TM6 L 286 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 L 286 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 A 289 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 289 6x29 G.H5 M 379 G.H5.24
Polar ICL1 R 79 - G.H5 L 380 G.H5.25
Hydrophobic ICL1 R 79 - G.H5 L 380 G.H5.25
Hydrophobic ICL2 H 155 - G.S1 V 58 G.S1.02
Van-der-waals ICL2 H 155 - G.S1 V 58 G.S1.02
Hydrophobic TM3 V 151 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 151 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM2 D 83 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 D 83 2x40 G.H5 L 380 G.H5.25
Polar TM3 A 150 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 150 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 150 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL3 P 277 - G.H4 Q 328 G.H4.08
Van-der-waals ICL3 P 277 - G.H4 Q 328 G.H4.08
Hydrophobic TM3 V 151 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 151 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 H 155 - G.H5 K 367 G.H5.12
Hydrophobic TM6 A 285 6x25 G.H5 Q 372 G.H5.17
Hydrophobic TM6 L 286 6x26 G.H5 D 368 G.H5.13
Van-der-waals TM6 L 286 6x26 G.H5 D 368 G.H5.13
Hydrophobic TM6 L 286 6x26 G.H5 L 375 G.H5.20
Hydrophobic TM6 Q 292 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 Q 292 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM6 A 285 6x25 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 A 285 6x25 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 W 273 5x79 G.H4 D 326 G.H4.06
Van-der-waals TM5 W 273 5x79 G.H4 D 326 G.H4.06
Polar ICL1 K 78 - G.H5 D 377 G.H5.22
Hydrophobic ICL1 K 78 - G.H5 D 377 G.H5.22
Van-der-waals ICL1 K 78 - G.H5 D 377 G.H5.22
Hydrophobic TM6 K 290 6x30 G.H5 L 371 G.H5.16
Van-der-waals TM6 K 290 6x30 G.H5 L 371 G.H5.16
Polar H8 Q 356 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 Q 356 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 Q 356 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 154 - G.H5 K 367 G.H5.12
Polar ICL1 R 79 - G.H5 Q 381 G.H5.26
Hydrophobic ICL1 R 79 - G.H5 Q 381 G.H5.26
Van-der-waals ICL1 R 79 - G.H5 Q 381 G.H5.26
Hydrophobic TM6 A 289 6x29 G.H5 L 375 G.H5.20
Polar TM6 Q 292 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 Q 292 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM5 W 273 5x79 G.H4 R 329 G.H4.09
Van-der-waals TM5 W 273 5x79 G.H4 R 329 G.H4.09
Hydrophobic TM2 M 82 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM6 S 293 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM2 L 86 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 L 86 2x43 G.H5 L 380 G.H5.25
Hydrophobic C-term A 433 - H.hbhc G 139 H.hbhc.03
Polar ICL2 P 154 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 154 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 154 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 H 155 - G.S3 I 221 G.S3.01
Polar H8 D 359 8x50 G.H5 Q 381 G.H5.26
Hydrophobic H8 D 359 8x50 G.H5 Q 381 G.H5.26
Van-der-waals H8 D 359 8x50 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 P 154 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 154 - G.H5 I 370 G.H5.15
Polar TM4 R 157 4x38 G.HN R 52 G.HN.52
Hydrophobic TM4 R 157 4x38 G.HN R 52 G.HN.52
Polar ICL3 G 278 - G.S6 H 349 G.S6.04
Hydrophobic ICL3 G 278 - G.S6 H 349 G.S6.04
Van-der-waals ICL3 G 278 - G.S6 H 349 G.S6.04
Polar TM3 R 147 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 147 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 147 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM4 R 157 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 R 157 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 P 154 - G.H5 L 371 G.H5.16
Polar ICL1 K 78 - G.H5 N 374 G.H5.19
Hydrophobic ICL1 K 78 - G.H5 N 374 G.H5.19
Van-der-waals ICL1 K 78 - G.H5 N 374 G.H5.19
Aromatic C-term F 434 - G.hfs2 K 209 G.hfs2.06
Hydrophobic C-term F 434 - G.hfs2 K 209 G.hfs2.06
Van-der-waals C-term F 434 - G.hfs2 K 209 G.hfs2.06
Hydrophobic TM6 L 286 6x26 G.H5 L 371 G.H5.16
Van-der-waals TM6 L 286 6x26 G.H5 L 371 G.H5.16
Hydrophobic TM3 A 150 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 150 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM2 M 82 2x39 G.H5 L 380 G.H5.25
Hydrophobic ICL3 A 282 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 A 282 - G.S6 F 347 G.S6.02
Hydrophobic TM7 Y 352 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 352 7x53 G.H5 L 380 G.H5.25
Hydrophobic ICL3 P 277 - G.HG M 298 G.HG.01