Gt2 - GPR150 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 72.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 H 155 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 H 155 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 H 155 - G.H5 T 340 G.H5.12
Hydrophobic ICL3 P 277 - G.H4 N 301 G.H4.08
Polar ICL3 R 279 - G.H5 Q 330 G.H5.02
Van-der-waals ICL3 R 279 - G.H5 Q 330 G.H5.02
Polar C-term Y 403 - G.HG I 285 G.HG.17
Hydrophobic C-term Y 403 - G.HG I 285 G.HG.17
Van-der-waals C-term Y 403 - G.HG I 285 G.HG.17
Van-der-waals C-term A 433 - G.H2 R 208 G.H2.04
Ionic TM4 R 162 4x43 G.HN E 20 G.HN.44
Polar TM4 R 162 4x43 G.HN E 20 G.HN.44
Hydrophobic C-term A 433 - G.H3 S 252 G.H3.11
Polar TM2 R 80 2x37 G.H5 K 349 G.H5.21
Hydrophobic TM2 R 80 2x37 G.H5 K 349 G.H5.21
Van-der-waals TM2 R 80 2x37 G.H5 K 349 G.H5.21
Ionic C-term R 395 - G.H4 D 309 G.H4.17
Polar C-term R 395 - G.H4 D 309 G.H4.17
Hydrophobic C-term R 395 - G.H4 D 309 G.H4.17
Van-der-waals C-term R 395 - G.H4 D 309 G.H4.17
Hydrophobic TM6 A 285 6x25 G.H5 K 345 G.H5.17
Hydrophobic TM3 R 147 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 147 3x50 G.H5 L 353 G.H5.25
Aromatic C-term F 434 - G.h2s4 F 215 G.h2s4.01
Hydrophobic C-term F 434 - G.h2s4 F 215 G.h2s4.01
Van-der-waals C-term F 434 - G.h2s4 F 215 G.h2s4.01
Aromatic C-term W 398 - G.H3 H 244 G.H3.03
Hydrophobic C-term W 398 - G.H3 H 244 G.H3.03
Van-der-waals C-term W 398 - G.H3 H 244 G.H3.03
Aromatic C-term F 434 - G.H3 H 256 G.H3.15
Hydrophobic C-term F 434 - G.H3 H 256 G.H3.15
Hydrophobic C-term P 401 - G.H3 H 244 G.H3.03
Polar TM3 R 147 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 R 147 3x50 G.H5 G 352 G.H5.24
Hydrophobic ICL2 H 155 - G.H5 I 344 G.H5.16
Polar TM6 A 285 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 A 285 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 A 285 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic C-term H 405 - H.HD E 145 H.HD.12
Hydrophobic TM6 A 289 6x29 G.H5 L 348 G.H5.20
Hydrophobic TM3 V 151 3x54 G.H5 L 348 G.H5.20
Hydrophobic C-term P 401 - G.hgh4 P 288 G.hgh4.03
Polar ICL2 P 154 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 154 - G.H5 N 347 G.H5.19
Hydrophobic C-term F 434 - G.H2 W 211 G.H2.07
Van-der-waals C-term F 434 - G.H2 W 211 G.H2.07
Hydrophobic TM4 R 157 4x38 G.hns1 K 32 G.hns1.03
Van-der-waals TM4 R 157 4x38 G.hns1 K 32 G.hns1.03
Polar C-term Y 403 - G.hgh4 C 286 G.hgh4.01
Hydrophobic C-term Y 403 - G.hgh4 C 286 G.hgh4.01
Van-der-waals C-term Y 403 - G.hgh4 C 286 G.hgh4.01
Hydrophobic ICL3 A 282 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 A 282 - G.S6 Y 320 G.S6.02
Hydrophobic TM6 L 286 6x26 G.H5 I 344 G.H5.16
Van-der-waals TM6 L 286 6x26 G.H5 I 344 G.H5.16
Polar TM6 S 293 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 S 293 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 293 6x33 G.H5 L 353 G.H5.25
Polar TM3 R 147 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 147 3x50 G.H5 C 351 G.H5.23
Hydrophobic C-term F 434 - G.H2 R 208 G.H2.04
Van-der-waals C-term F 434 - G.H2 R 208 G.H2.04
Hydrophobic TM3 V 151 3x54 G.H5 L 353 G.H5.25
Ionic TM2 R 80 2x37 G.H5 D 350 G.H5.22
Polar TM2 R 80 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 80 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 80 2x37 G.H5 D 350 G.H5.22
Hydrophobic C-term W 398 - G.H4 Q 306 G.H4.14
Van-der-waals C-term W 398 - G.H4 Q 306 G.H4.14
Polar C-term Y 403 - G.s4h3 Y 230 G.s4h3.04
Van-der-waals C-term Y 403 - G.s4h3 Y 230 G.s4h3.04
Aromatic C-term W 398 - G.hgh4 F 287 G.hgh4.02
Hydrophobic C-term W 398 - G.hgh4 F 287 G.hgh4.02
Van-der-waals C-term W 398 - G.hgh4 F 287 G.hgh4.02
Hydrophobic ICL2 P 154 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 154 - G.H5 I 344 G.H5.16
Hydrophobic C-term A 433 - G.H3 L 249 G.H3.08
Hydrophobic TM3 A 150 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 150 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL3 P 277 - G.H4 D 297 G.H4.04
Van-der-waals ICL3 P 277 - G.H4 D 297 G.H4.04
Hydrophobic TM6 A 289 6x29 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 289 6x29 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 286 6x26 G.H5 D 341 G.H5.13
Hydrophobic C-term H 400 - G.s4h3 V 240 G.s4h3.14
Ionic C-term H 402 - G.s4h3 E 239 G.s4h3.13
Polar C-term H 402 - G.s4h3 E 239 G.s4h3.13
Hydrophobic C-term H 402 - G.s4h3 E 239 G.s4h3.13
Van-der-waals C-term H 402 - G.s4h3 E 239 G.s4h3.13
Polar TM2 M 82 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 M 82 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 M 82 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 A 285 6x25 G.H5 F 354 G.H5.26
Polar C-term Y 403 - G.s4h3 N 241 G.s4h3.15
Hydrophobic C-term Y 403 - G.s4h3 N 241 G.s4h3.15
Van-der-waals C-term Y 403 - G.s4h3 N 241 G.s4h3.15
Hydrophobic C-term Y 403 - G.H3 H 244 G.H3.03
Hydrophobic ICL3 A 275 - G.H4 D 297 G.H4.04
Van-der-waals ICL3 A 275 - G.H4 D 297 G.H4.04
Hydrophobic TM2 M 82 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 M 82 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 286 6x26 G.H5 L 348 G.H5.20
Ionic TM4 R 157 4x38 G.HN D 28 G.HN.52
Polar TM4 R 157 4x38 G.HN D 28 G.HN.52
Hydrophobic TM4 R 157 4x38 G.HN D 28 G.HN.52
Hydrophobic TM6 A 289 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 289 6x29 G.H5 F 354 G.H5.26