G12 - GPR157 complex model

GPCR CLASS (FAMILY)

Unclassified

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR157 77.1
subunit alpha-12 84.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 S 44 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 S 44 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 S 44 2x37 G.H5 D 377 G.H5.22
Hydrophobic ICL1 L 42 12x50 G.H5 K 376 G.H5.21
Hydrophobic TM6 K 226 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 K 226 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM6 L 217 6x27 G.H5 L 371 G.H5.16
Hydrophobic TM7 F 279 7x53 G.H5 M 379 G.H5.24
Polar TM2 S 44 2x37 G.H5 K 376 G.H5.21
Hydrophobic TM6 L 216 6x26 G.hns1 R 56 G.hns1.03
Van-der-waals TM6 L 216 6x26 G.hns1 R 56 G.hns1.03
Hydrophobic TM2 A 46 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM3 L 104 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 104 3x50 G.H5 I 378 G.H5.23
Hydrophobic H8 T 283 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 T 283 8x47 G.H5 Q 381 G.H5.26
Hydrophobic TM6 L 216 6x26 G.s2s3 K 220 G.s2s3.02
Hydrophobic TM3 I 108 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM6 A 223 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 A 223 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM6 L 227 6x37 G.H5 L 380 G.H5.25
Van-der-waals TM6 L 227 6x37 G.H5 L 380 G.H5.25
Polar TM6 K 226 6x36 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 226 6x36 G.H5 Q 381 G.H5.26
Hydrophobic TM2 A 46 2x39 G.H5 M 379 G.H5.24
Van-der-waals TM2 A 46 2x39 G.H5 M 379 G.H5.24
Hydrophobic ICL1 D 41 12x49 G.h4s6 S 343 G.h4s6.12
Polar TM6 K 226 6x36 G.H5 M 379 G.H5.24
Polar TM6 A 223 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 223 6x33 G.H5 L 380 G.H5.25
Van-der-waals TM6 A 223 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM3 A 111 3x57 G.hns1 R 55 G.hns1.02
Van-der-waals TM3 A 111 3x57 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 M 222 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM2 R 47 2x40 G.H5 M 379 G.H5.24
Van-der-waals TM2 R 47 2x40 G.H5 M 379 G.H5.24
Polar TM3 V 109 3x55 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 V 109 3x55 G.hns1 R 55 G.hns1.02
Van-der-waals TM3 V 109 3x55 G.hns1 R 55 G.hns1.02
Ionic TM6 E 213 6x23 G.HN R 52 G.HN.52
Hydrophobic TM6 E 213 6x23 G.HN R 52 G.HN.52
Van-der-waals TM6 E 213 6x23 G.HN R 52 G.HN.52
Van-der-waals TM2 R 47 2x40 G.H5 Q 381 G.H5.26
Polar TM2 A 46 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM2 A 46 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 A 46 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM3 I 108 3x54 G.H5 L 380 G.H5.25
Polar TM3 R 110 3x56 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 R 110 3x56 G.hns1 R 55 G.hns1.02
Van-der-waals TM3 R 110 3x56 G.hns1 R 55 G.hns1.02
Hydrophobic H8 A 285 8x49 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 R 113 - G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 R 113 - G.h2s4 T 246 G.h2s4.05
Ionic ICL1 D 41 12x49 G.H5 K 376 G.H5.21
Polar ICL1 D 41 12x49 G.H5 K 376 G.H5.21
Hydrophobic ICL1 D 41 12x49 G.H5 K 376 G.H5.21
Van-der-waals ICL1 D 41 12x49 G.H5 K 376 G.H5.21
Hydrophobic TM2 L 50 2x43 G.H5 M 379 G.H5.24
Van-der-waals TM2 L 50 2x43 G.H5 M 379 G.H5.24
Hydrophobic TM3 S 107 3x53 G.H5 I 378 G.H5.23
Polar ICL2 R 113 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 R 113 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 113 - G.H5 N 374 G.H5.19
Ionic TM6 E 213 6x23 G.hns1 R 56 G.hns1.03
Polar TM6 E 213 6x23 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 E 213 6x23 G.hns1 R 56 G.hns1.03
Van-der-waals TM6 E 213 6x23 G.hns1 R 56 G.hns1.03