G12 - GPR176 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 67.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 16.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 142 3x50 G.H5 I 378 G.H5.23
Hydrophobic C-term G 456 - G.h4s6 R 340 G.h4s6.09
Van-der-waals C-term G 456 - G.h4s6 R 340 G.h4s6.09
Polar C-term N 481 - G.hfs2 K 209 G.hfs2.06
Hydrophobic C-term N 481 - G.hfs2 K 209 G.hfs2.06
Van-der-waals C-term N 481 - G.hfs2 K 209 G.hfs2.06
Hydrophobic C-term F 510 - G.s4h3 V 260 G.s4h3.07
Van-der-waals C-term F 510 - G.s4h3 V 260 G.s4h3.07
Hydrophobic C-term F 373 - G.H2 F 239 G.H2.08
Hydrophobic TM7 F 320 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 320 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM3 V 146 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 146 3x54 G.H5 L 371 G.H5.16
Polar TM6 R 260 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 R 260 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 260 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM5 I 242 5x75 G.H5 F 361 G.H5.06
Hydrophobic TM3 V 146 3x54 G.H5 L 375 G.H5.20
Hydrophobic C-term M 372 - G.H2 R 232 G.H2.01
Van-der-waals C-term M 372 - G.H2 R 232 G.H2.01
Hydrophobic TM6 Y 256 6x25 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 Y 256 6x25 G.h4s6 S 343 G.h4s6.12
Hydrophobic C-term L 460 - G.H3 N 283 G.H3.15
Van-der-waals C-term L 460 - G.H3 N 283 G.H3.15
Hydrophobic TM2 I 80 2x43 G.H5 L 380 G.H5.25
Hydrophobic TM6 Y 256 6x25 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 P 149 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 149 - G.H5 I 370 G.H5.15
Polar C-term N 505 - H.HA D 110 H.HA.24
Hydrophobic C-term N 505 - H.HA D 110 H.HA.24
Van-der-waals C-term N 505 - H.HA D 110 H.HA.24
Hydrophobic C-term L 479 - G.S2 H 214 G.S2.04
Van-der-waals C-term L 479 - G.S2 H 214 G.S2.04
Polar TM5 R 246 5x79 G.S6 H 348 G.S6.03
Aromatic TM5 R 246 5x79 G.S6 H 348 G.S6.03
Van-der-waals TM5 R 246 5x79 G.S6 H 348 G.S6.03
Hydrophobic C-term M 501 - H.HA R 106 H.HA.20
Van-der-waals C-term M 501 - H.HA R 106 H.HA.20
Hydrophobic TM6 A 257 6x26 G.H5 Q 372 G.H5.17
Polar C-term N 505 - H.HA K 114 H.HA.28
Hydrophobic C-term N 505 - H.HA K 114 H.HA.28
Van-der-waals C-term N 505 - H.HA K 114 H.HA.28
Polar C-term T 482 - G.hfs2 R 205 G.hfs2.02
Hydrophobic C-term F 373 - G.h2s4 F 242 G.h2s4.01
Polar C-term M 501 - H.HA K 114 H.HA.28
Polar ICL1 K 73 12x51 G.H5 N 374 G.H5.19
Van-der-waals ICL1 K 73 12x51 G.H5 N 374 G.H5.19
Hydrophobic C-term R 469 - G.HN R 51 G.HN.51
Hydrophobic ICL2 L 150 - G.H5 V 366 G.H5.11
Hydrophobic ICL3 I 252 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 E 261 6x30 G.H5 L 371 G.H5.16
Van-der-waals TM6 E 261 6x30 G.H5 L 371 G.H5.16
Hydrophobic TM6 L 264 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 L 264 6x33 G.H5 L 375 G.H5.20
Hydrophobic C-term M 372 - G.H2 R 235 G.H2.04
Polar C-term T 482 - G.hfs2 A 207 G.hfs2.04
Hydrophobic C-term T 482 - G.hfs2 A 207 G.hfs2.04
Van-der-waals C-term T 482 - G.hfs2 A 207 G.hfs2.04
Polar C-term N 505 - H.hdhe Q 174 H.hdhe.02
Ionic C-term E 484 - H.HA K 103 H.HA.17
Polar C-term E 484 - H.HA K 103 H.HA.17
Hydrophobic C-term E 484 - H.HA K 103 H.HA.17
Van-der-waals C-term E 484 - H.HA K 103 H.HA.17
Hydrophobic C-term S 508 - G.s4h3 V 260 G.s4h3.07
Van-der-waals C-term S 508 - G.s4h3 V 260 G.s4h3.07
Hydrophobic ICL2 L 150 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 150 - G.H5 I 370 G.H5.15
Hydrophobic C-term V 507 - H.HA L 115 H.HA.29
Van-der-waals C-term V 507 - H.HA L 115 H.HA.29
Hydrophobic C-term L 479 - G.hfs2 T 208 G.hfs2.05
Van-der-waals C-term L 479 - G.hfs2 T 208 G.hfs2.05
Polar H8 S 326 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 S 326 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 S 326 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM6 Y 256 6x25 G.H5 Q 372 G.H5.17
Polar C-term F 458 - G.H3 K 284 G.H3.16
Van-der-waals C-term F 458 - G.H3 K 284 G.H3.16
Polar C-term S 502 - H.HA D 110 H.HA.24
Hydrophobic C-term F 510 - G.hgh4 H 313 G.hgh4.01
Aromatic TM5 R 246 5x79 G.H5 F 361 G.H5.06
Hydrophobic TM5 R 246 5x79 G.H5 F 361 G.H5.06
Van-der-waals TM5 R 246 5x79 G.H5 F 361 G.H5.06
Hydrophobic TM6 I 254 6x23 G.H5 A 365 G.H5.10
Polar C-term T 482 - G.hfs2 K 209 G.hfs2.06
Hydrophobic C-term T 482 - G.hfs2 K 209 G.hfs2.06
Polar C-term N 505 - H.HA V 107 H.HA.21
Hydrophobic C-term N 505 - H.HA V 107 H.HA.21
Van-der-waals C-term N 505 - H.HA V 107 H.HA.21
Polar TM5 R 246 5x79 G.S6 H 349 G.S6.04
Aromatic TM5 R 246 5x79 G.S6 H 349 G.S6.04
Hydrophobic TM5 R 246 5x79 G.S6 H 349 G.S6.04
Van-der-waals TM5 R 246 5x79 G.S6 H 349 G.S6.04
Van-der-waals C-term P 477 - G.S2 V 212 G.S2.02
Polar ICL2 K 153 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 K 153 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 K 153 - G.H5 N 374 G.H5.19
Polar C-term N 504 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term N 504 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term N 504 - G.s4h3 R 265 G.s4h3.12
Polar C-term S 508 - H.HD E 172 H.HD.12
Van-der-waals C-term S 508 - H.HD E 172 H.HD.12
Polar C-term P 483 - G.hfs2 A 207 G.hfs2.04
Hydrophobic C-term P 483 - G.hfs2 A 207 G.hfs2.04
Van-der-waals C-term P 483 - G.hfs2 A 207 G.hfs2.04
Polar TM3 S 145 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 145 3x53 G.H5 N 374 G.H5.19
Polar TM4 S 155 4x38 G.HN R 52 G.HN.52
Hydrophobic TM4 S 155 4x38 G.HN R 52 G.HN.52
Ionic ICL1 K 73 12x51 G.H5 D 377 G.H5.22
Polar ICL1 K 73 12x51 G.H5 D 377 G.H5.22
Hydrophobic ICL1 K 73 12x51 G.H5 D 377 G.H5.22
Van-der-waals ICL1 K 73 12x51 G.H5 D 377 G.H5.22
Polar H8 V 327 8x50 G.H5 L 380 G.H5.25
Hydrophobic H8 V 327 8x50 G.H5 L 380 G.H5.25
Van-der-waals H8 V 327 8x50 G.H5 L 380 G.H5.25
Hydrophobic ICL1 F 72 12x50 G.H5 L 380 G.H5.25
Van-der-waals ICL1 F 72 12x50 G.H5 L 380 G.H5.25
Hydrophobic TM7 V 323 7x56 G.H5 M 379 G.H5.24
Hydrophobic C-term G 480 - G.hfs2 K 206 G.hfs2.03
Hydrophobic TM3 S 145 3x53 G.H5 L 371 G.H5.16
Hydrophobic C-term M 501 - H.HB M 132 H.HB.10
Van-der-waals C-term M 501 - H.HB M 132 H.HB.10
Hydrophobic TM6 E 263 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 E 263 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM4 A 157 4x40 G.HN R 52 G.HN.52
Hydrophobic TM5 T 247 5x80 G.H4 Q 328 G.H4.08
Van-der-waals TM5 T 247 5x80 G.H4 Q 328 G.H4.08
Hydrophobic C-term R 469 - G.HN L 47 G.HN.47
Hydrophobic TM6 E 261 6x30 G.H5 L 375 G.H5.20
Van-der-waals TM6 E 261 6x30 G.H5 L 375 G.H5.20
Hydrophobic TM6 I 254 6x23 G.S6 F 347 G.S6.02
Van-der-waals TM6 I 254 6x23 G.S6 F 347 G.S6.02
Hydrophobic ICL2 L 150 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 L 150 - G.H5 K 367 G.H5.12
Hydrophobic C-term K 506 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term K 506 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term W 464 - G.H2 F 239 G.H2.08
Van-der-waals C-term W 464 - G.H2 F 239 G.H2.08
Ionic C-term E 485 - H.HA K 103 H.HA.17
Polar C-term E 485 - H.HA K 103 H.HA.17
Van-der-waals C-term E 485 - H.HA K 103 H.HA.17
Hydrophobic TM6 R 260 6x29 G.H5 L 375 G.H5.20
Hydrophobic H8 K 325 8x48 G.H5 Q 381 G.H5.26
Hydrophobic C-term L 460 - G.H3 K 284 G.H3.16
Hydrophobic C-term F 510 - G.s4h3 D 258 G.s4h3.05
Van-der-waals C-term F 510 - G.s4h3 D 258 G.s4h3.05
Polar H8 S 326 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 S 326 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 S 326 8x49 G.H5 Q 381 G.H5.26
Polar C-term N 481 - G.hfs2 K 206 G.hfs2.03
Hydrophobic C-term N 481 - G.hfs2 K 206 G.hfs2.03
Van-der-waals C-term N 481 - G.hfs2 K 206 G.hfs2.03
Hydrophobic TM2 T 76 2x39 G.H5 I 378 G.H5.23
Hydrophobic C-term V 507 - H.HD E 172 H.HD.12
Van-der-waals C-term V 507 - H.HD E 172 H.HD.12
Hydrophobic TM5 T 247 5x80 G.S6 F 350 G.S6.05
Hydrophobic C-term G 376 - G.H2 F 239 G.H2.08
Hydrophobic ICL2 L 150 - G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 150 - G.S1 V 58 G.S1.02
Polar ICL3 Q 249 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 Q 249 - G.H4 R 329 G.H4.09
Hydrophobic C-term L 479 - G.S2 V 212 G.S2.02
Van-der-waals C-term L 479 - G.S2 V 212 G.S2.02
Van-der-waals C-term T 482 - G.hfs2 K 206 G.hfs2.03
Ionic ICL1 K 73 12x51 G.H5 E 373 G.H5.18
Polar ICL1 K 73 12x51 G.H5 E 373 G.H5.18
Hydrophobic ICL1 K 73 12x51 G.H5 E 373 G.H5.18
Van-der-waals ICL1 K 73 12x51 G.H5 E 373 G.H5.18
Hydrophobic ICL2 L 150 - G.S3 F 223 G.S3.03
Hydrophobic C-term L 479 - G.S3 D 227 G.S3.07
Hydrophobic TM6 R 260 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 260 6x29 G.H5 M 379 G.H5.24
Hydrophobic ICL2 R 152 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 152 - G.hns1 R 56 G.hns1.03
Hydrophobic TM6 R 260 6x29 G.H5 K 376 G.H5.21
Van-der-waals TM6 R 260 6x29 G.H5 K 376 G.H5.21
Polar TM3 L 147 3x55 G.H5 K 367 G.H5.12
Van-der-waals TM3 L 147 3x55 G.H5 K 367 G.H5.12
Hydrophobic C-term F 510 - G.s4h3 Q 259 G.s4h3.06
Hydrophobic H8 N 324 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 324 8x47 G.H5 L 380 G.H5.25
Polar ICL2 R 152 - G.HN R 52 G.HN.52
Hydrophobic ICL2 R 152 - G.HN R 52 G.HN.52
Van-der-waals ICL2 R 152 - G.HN R 52 G.HN.52
Polar ICL2 P 149 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 149 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 149 - G.H5 N 374 G.H5.19
Hydrophobic TM6 I 254 6x23 G.H5 Q 372 G.H5.17
Van-der-waals TM6 I 254 6x23 G.H5 Q 372 G.H5.17
Hydrophobic C-term P 478 - G.S2 V 212 G.S2.02
Hydrophobic C-term L 460 - G.H3 L 285 G.H3.17
Van-der-waals C-term L 460 - G.H3 L 285 G.H3.17
Hydrophobic C-term M 501 - H.HA D 110 H.HA.24
Hydrophobic C-term F 458 - G.H3 T 279 G.H3.11
Van-der-waals C-term F 458 - G.H3 T 279 G.H3.11
Hydrophobic ICL2 P 149 - G.H5 L 371 G.H5.16
Hydrophobic TM5 I 242 5x75 G.H5 H 364 G.H5.09
Van-der-waals TM5 I 242 5x75 G.H5 H 364 G.H5.09
Hydrophobic C-term M 372 - G.H2 Q 236 G.H2.05
Van-der-waals C-term M 372 - G.H2 Q 236 G.H2.05
Hydrophobic TM6 I 254 6x23 G.H5 D 368 G.H5.13
Van-der-waals TM6 I 254 6x23 G.H5 D 368 G.H5.13
Hydrophobic H8 N 324 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 N 324 8x47 G.H5 M 379 G.H5.24
Hydrophobic C-term I 380 - G.H2 F 239 G.H2.08
Van-der-waals C-term I 380 - G.H2 F 239 G.H2.08
Hydrophobic TM3 S 145 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 S 145 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM6 P 255 6x24 G.h4s6 P 345 G.h4s6.20
Hydrophobic C-term V 507 - H.HA K 114 H.HA.28
Ionic TM5 K 239 5x72 G.H5 D 368 G.H5.13
Polar TM5 K 239 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 239 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 239 5x72 G.H5 D 368 G.H5.13
Hydrophobic C-term W 464 - G.H3 L 285 G.H3.17
Hydrophobic C-term L 369 - G.H3 T 279 G.H3.11
Hydrophobic C-term P 483 - G.hfs2 K 209 G.hfs2.06
Van-der-waals C-term P 483 - G.hfs2 K 209 G.hfs2.06
Polar C-term S 502 - H.HA K 114 H.HA.28
Hydrophobic C-term S 502 - H.HA K 114 H.HA.28
Van-der-waals C-term S 502 - H.HA K 114 H.HA.28
Hydrophobic ICL2 L 150 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 150 - G.H5 F 363 G.H5.08
Polar TM6 E 263 6x32 G.H5 Q 381 G.H5.26
Polar C-term R 503 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term R 503 - G.s4h3 R 265 G.s4h3.12
Hydrophobic TM6 L 264 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 264 6x33 G.H5 M 379 G.H5.24
Polar C-term P 483 - G.s3h2 Q 231 G.s3h2.03
Hydrophobic C-term P 483 - G.s3h2 Q 231 G.s3h2.03
Van-der-waals C-term P 483 - G.s3h2 Q 231 G.s3h2.03
Hydrophobic C-term P 483 - G.hfs2 T 208 G.hfs2.05
Ionic TM4 D 156 4x39 G.hns1 R 55 G.hns1.02
Polar TM4 D 156 4x39 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 D 156 4x39 G.hns1 R 55 G.hns1.02
Hydrophobic C-term L 476 - G.S2 I 211 G.S2.01
Van-der-waals C-term L 476 - G.S2 I 211 G.S2.01
Hydrophobic C-term N 505 - H.hdhe F 173 H.hdhe.01
Ionic C-term E 459 - G.H3 K 284 G.H3.16
Polar C-term E 459 - G.H3 K 284 G.H3.16
Hydrophobic C-term E 459 - G.H3 K 284 G.H3.16
Van-der-waals C-term E 459 - G.H3 K 284 G.H3.16
Hydrophobic C-term F 458 - G.H3 N 283 G.H3.15
Van-der-waals C-term F 458 - G.H3 N 283 G.H3.15
Hydrophobic ICL2 L 150 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 150 - G.S3 I 221 G.S3.01
Ionic ICL2 K 153 - G.H5 D 377 G.H5.22
Polar ICL2 K 153 - G.H5 D 377 G.H5.22
Van-der-waals ICL2 K 153 - G.H5 D 377 G.H5.22
Hydrophobic ICL2 P 149 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 149 - G.H5 K 367 G.H5.12
Hydrophobic TM6 L 264 6x33 G.H5 I 378 G.H5.23
Van-der-waals TM6 L 264 6x33 G.H5 I 378 G.H5.23
Hydrophobic C-term L 369 - G.H2 R 235 G.H2.04