Gs - GPR176 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 67.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 S 145 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 S 145 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 145 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 150 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 L 150 - G.H5 R 380 G.H5.12
Hydrophobic ICL1 F 72 12x50 G.H5 E 392 G.H5.24
Van-der-waals ICL1 F 72 12x50 G.H5 E 392 G.H5.24
Hydrophobic TM6 Y 256 6x25 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 Y 256 6x25 G.h4s6 Y 358 G.h4s6.20
Polar TM5 R 246 5x79 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 R 246 5x79 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 R 246 5x79 G.hgh4 D 323 G.hgh4.13
Polar TM5 K 239 5x72 G.H5 Q 384 G.H5.16
Aromatic C-term F 373 - G.H3 R 280 G.H3.16
Hydrophobic TM3 V 146 3x54 G.H5 L 388 G.H5.20
Polar H8 S 326 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 S 326 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 S 326 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM5 L 245 5x78 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 L 245 5x78 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 L 245 5x78 G.hgh4 A 324 G.hgh4.14
Hydrophobic ICL1 F 72 12x50 G.H5 Y 391 G.H5.23
Van-der-waals ICL1 F 72 12x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 I 252 - G.h4s6 T 350 G.h4s6.03
Polar TM1 T 69 1x60 G.H5 E 392 G.H5.24
Ionic C-term R 474 - G.h2s4 D 240 G.h2s4.03
Polar TM5 R 246 5x79 G.S6 P 361 G.S6.03
Hydrophobic TM5 R 246 5x79 G.S6 P 361 G.S6.03
Van-der-waals TM5 R 246 5x79 G.S6 P 361 G.S6.03
Hydrophobic TM6 I 254 6x23 G.H5 R 385 G.H5.17
Van-der-waals TM6 I 254 6x23 G.H5 R 385 G.H5.17
Hydrophobic ICL3 P 248 - G.hgh4 P 321 G.hgh4.11
Polar ICL3 P 248 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 P 248 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 P 248 - G.hgh4 D 323 G.hgh4.13
Polar TM3 S 145 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 S 145 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM6 L 264 6x33 G.H5 L 388 G.H5.20
Van-der-waals TM6 L 264 6x33 G.H5 L 388 G.H5.20
Hydrophobic C-term F 373 - G.H2 I 235 G.H2.08
Van-der-waals C-term F 373 - G.H2 I 235 G.H2.08
Polar ICL1 F 72 12x50 G.H5 Q 390 G.H5.22
Hydrophobic ICL1 F 72 12x50 G.H5 Q 390 G.H5.22
Van-der-waals ICL1 F 72 12x50 G.H5 Q 390 G.H5.22
Hydrophobic TM6 E 261 6x30 G.H5 L 388 G.H5.20
Van-der-waals TM6 E 261 6x30 G.H5 L 388 G.H5.20
Hydrophobic TM5 R 246 5x79 G.S6 Y 360 G.S6.02
Van-der-waals TM5 R 246 5x79 G.S6 Y 360 G.S6.02
Hydrophobic TM6 A 257 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM6 A 257 6x26 G.H5 R 385 G.H5.17
Polar TM6 R 260 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 260 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 260 6x29 G.H5 L 394 G.H5.26
Hydrophobic ICL1 V 71 12x49 G.H5 E 392 G.H5.24
Van-der-waals ICL1 V 71 12x49 G.H5 E 392 G.H5.24
Hydrophobic TM6 I 254 6x23 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 I 254 6x23 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 L 264 6x33 G.H5 L 394 G.H5.26
Van-der-waals TM6 L 264 6x33 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 150 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 150 - G.S3 V 217 G.S3.01
Polar ICL2 P 149 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 149 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 149 - G.H5 H 387 G.H5.19
Hydrophobic C-term L 460 - G.H3 R 280 G.H3.16
Hydrophobic TM6 L 264 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 264 6x33 G.H5 L 393 G.H5.25
Hydrophobic C-term F 458 - G.H3 N 279 G.H3.15
Van-der-waals C-term F 458 - G.H3 N 279 G.H3.15
Hydrophobic TM6 E 261 6x30 G.H5 L 394 G.H5.26
Van-der-waals TM6 E 261 6x30 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 150 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 150 - G.H5 F 376 G.H5.08
Hydrophobic C-term L 460 - G.H3 W 281 G.H3.17
Van-der-waals C-term L 460 - G.H3 W 281 G.H3.17
Polar TM3 V 146 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 146 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 146 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM5 R 246 5x79 G.H4 R 342 G.H4.12
Van-der-waals TM5 R 246 5x79 G.H4 R 342 G.H4.12
Hydrophobic TM3 R 142 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM3 R 142 3x50 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 149 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 149 - G.H5 Q 384 G.H5.16
Aromatic TM5 R 246 5x79 G.S6 H 362 G.S6.04
Polar TM5 R 246 5x79 G.S6 C 359 G.S6.01
Van-der-waals TM5 R 246 5x79 G.S6 C 359 G.S6.01
Polar ICL2 L 150 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 150 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 150 - G.S1 H 41 G.S1.02
Hydrophobic TM5 R 246 5x79 G.H4 L 346 G.H4.16
Polar H8 N 324 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 N 324 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 324 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 149 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 149 - G.H5 I 383 G.H5.15
Polar ICL1 K 73 12x51 G.H5 Y 391 G.H5.23
Aromatic ICL1 K 73 12x51 G.H5 Y 391 G.H5.23
Hydrophobic ICL1 K 73 12x51 G.H5 Y 391 G.H5.23
Van-der-waals ICL1 K 73 12x51 G.H5 Y 391 G.H5.23
Polar C-term E 459 - G.H3 R 280 G.H3.16
Hydrophobic C-term E 459 - G.H3 R 280 G.H3.16
Van-der-waals C-term E 459 - G.H3 R 280 G.H3.16
Polar ICL1 K 73 12x51 G.H5 H 387 G.H5.19
Hydrophobic ICL1 K 73 12x51 G.H5 H 387 G.H5.19
Van-der-waals ICL1 K 73 12x51 G.H5 H 387 G.H5.19
Hydrophobic TM2 T 76 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 76 2x39 G.H5 Y 391 G.H5.23
Hydrophobic C-term L 476 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term L 476 - G.h2s4 N 239 G.h2s4.02
Polar C-term F 458 - G.H3 R 280 G.H3.16
Hydrophobic C-term F 458 - G.H3 R 280 G.H3.16
Van-der-waals C-term F 458 - G.H3 R 280 G.H3.16
Hydrophobic ICL2 P 149 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 149 - G.H5 R 380 G.H5.12
Hydrophobic TM6 Y 256 6x25 G.h4s6 G 355 G.h4s6.11
Van-der-waals TM6 Y 256 6x25 G.h4s6 G 355 G.h4s6.11
Hydrophobic C-term F 458 - G.H3 S 275 G.H3.11
Hydrophobic C-term F 458 - G.h2s4 F 238 G.h2s4.01
Polar ICL2 R 152 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 R 152 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 R 152 - G.HN Q 35 G.HN.52
Polar H8 V 327 8x50 G.H5 E 392 G.H5.24
Hydrophobic H8 V 327 8x50 G.H5 E 392 G.H5.24
Van-der-waals H8 V 327 8x50 G.H5 E 392 G.H5.24
Hydrophobic TM5 L 245 5x78 G.hgh4 T 325 G.hgh4.15
Van-der-waals TM5 L 245 5x78 G.hgh4 T 325 G.hgh4.15
Polar TM3 D 141 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 141 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 141 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 150 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 150 - G.H5 I 383 G.H5.15
Hydrophobic TM5 A 244 5x77 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 A 244 5x77 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 L 245 5x78 G.H4 Y 339 G.H4.08
Van-der-waals TM5 L 245 5x78 G.H4 Y 339 G.H4.08
Polar TM5 L 245 5x78 G.H4 R 342 G.H4.12
Hydrophobic TM5 L 245 5x78 G.H4 R 342 G.H4.12
Van-der-waals TM5 L 245 5x78 G.H4 R 342 G.H4.12
Ionic TM5 K 239 5x72 G.H5 D 381 G.H5.13
Polar TM5 K 239 5x72 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 239 5x72 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 239 5x72 G.H5 D 381 G.H5.13
Polar TM5 T 247 5x80 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 T 247 5x80 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 T 247 5x80 G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL1 V 71 12x49 G.H5 Q 390 G.H5.22
Van-der-waals ICL1 V 71 12x49 G.H5 Q 390 G.H5.22
Hydrophobic ICL1 K 73 12x51 G.H5 Q 390 G.H5.22
Van-der-waals ICL1 K 73 12x51 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 L 150 - G.H5 C 379 G.H5.11
Polar ICL2 K 153 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 K 153 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 K 153 - G.H5 H 387 G.H5.19