Gz - GPRC6 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 692 - G.S3 L 195 G.S3.01
Hydrophobic ICL2 K 696 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 K 696 - G.hns1 R 31 G.hns1.02
Hydrophobic C-term A 865 - G.s2s3 K 193 G.s2s3.01
Hydrophobic TM3 A 687 3x57 G.H5 I 352 G.H5.23
Van-der-waals TM3 A 687 3x57 G.H5 I 352 G.H5.23
Hydrophobic ICL2 K 693 - G.HN Q 28 G.HN.52
Van-der-waals ICL2 K 693 - G.HN Q 28 G.HN.52
Hydrophobic C-term I 853 - G.H5 I 345 G.H5.16
Van-der-waals C-term I 853 - G.H5 I 345 G.H5.16
Polar C-term V 861 - G.s2s3 K 193 G.s2s3.01
Hydrophobic C-term V 861 - G.s2s3 K 193 G.s2s3.01
Van-der-waals C-term V 861 - G.s2s3 K 193 G.s2s3.01
Polar ICL2 Q 695 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 Q 695 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 Q 695 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 F 690 - G.H5 I 345 G.H5.16
Hydrophobic C-term S 857 - G.H5 T 341 G.H5.12
Van-der-waals C-term S 857 - G.H5 T 341 G.H5.12
Polar ICL2 S 689 - G.H5 N 348 G.H5.19
Hydrophobic TM3 L 686 3x56 G.H5 I 352 G.H5.23
Van-der-waals TM3 L 686 3x56 G.H5 I 352 G.H5.23
Ionic C-term K 921 - G.h4s6 E 316 G.h4s6.09
Polar C-term K 921 - G.h4s6 E 316 G.h4s6.09
Hydrophobic C-term K 921 - G.h4s6 E 316 G.h4s6.09
Van-der-waals C-term K 921 - G.h4s6 E 316 G.h4s6.09
Polar C-term Y 854 - G.H5 Q 346 G.H5.17
Van-der-waals C-term Y 854 - G.H5 Q 346 G.H5.17
Hydrophobic C-term S 857 - G.H5 I 345 G.H5.16
Van-der-waals C-term S 857 - G.H5 I 345 G.H5.16
Hydrophobic ICL2 P 692 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 P 692 - G.hns1 R 31 G.hns1.02
Polar C-term Y 854 - G.H5 D 342 G.H5.13
Hydrophobic C-term Y 854 - G.H5 D 342 G.H5.13
Van-der-waals C-term Y 854 - G.H5 D 342 G.H5.13
Polar ICL2 K 699 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 K 699 - G.H5 N 348 G.H5.19
Hydrophobic TM3 K 683 3x53 G.H5 L 354 G.H5.25
Van-der-waals TM3 K 683 3x53 G.H5 L 354 G.H5.25
Hydrophobic TM3 A 687 3x57 G.H5 L 349 G.H5.20
Polar TM3 A 687 3x57 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 687 3x57 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 687 3x57 G.H5 N 348 G.H5.19
Hydrophobic ICL1 S 626 12x52 G.H5 L 354 G.H5.25
Van-der-waals ICL1 S 626 12x52 G.H5 L 354 G.H5.25
Hydrophobic TM3 F 688 3x58 G.H5 I 345 G.H5.16
Hydrophobic TM4 Y 702 4x30 G.H5 I 352 G.H5.23
Hydrophobic ICL2 K 693 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 693 - G.hns1 R 32 G.hns1.03
Hydrophobic H8 L 850 8x55 G.H5 Q 346 G.H5.17
Polar TM3 K 683 3x53 G.H5 I 352 G.H5.23
Hydrophobic TM3 K 683 3x53 G.H5 I 352 G.H5.23
Van-der-waals TM3 K 683 3x53 G.H5 I 352 G.H5.23
Polar ICL2 K 696 - G.HN S 27 G.HN.51
Polar C-term Y 854 - G.h4s6 E 319 G.h4s6.12
Van-der-waals C-term Y 854 - G.h4s6 E 319 G.h4s6.12
Hydrophobic C-term V 861 - G.H5 F 337 G.H5.08
Van-der-waals C-term V 861 - G.H5 F 337 G.H5.08
Polar C-term Y 854 - G.S6 Y 321 G.S6.02
Van-der-waals C-term Y 854 - G.S6 Y 321 G.S6.02
Hydrophobic ICL2 P 692 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 692 - G.hns1 R 32 G.hns1.03
Ionic ICL2 D 691 - G.hns1 R 32 G.hns1.03
Polar ICL2 D 691 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 D 691 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 691 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 690 - G.H5 I 344 G.H5.15
Hydrophobic ICL2 F 690 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 F 690 - G.S3 L 195 G.S3.01
Hydrophobic ICL2 K 693 - G.HN R 29 G.HN.53
Hydrophobic ICL2 Q 695 - G.H5 I 344 G.H5.15
Hydrophobic C-term I 864 - G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 K 696 - G.HN Q 28 G.HN.52
Hydrophobic ICL2 D 691 - G.S3 L 195 G.S3.01
Hydrophobic ICL2 F 690 - G.H5 T 341 G.H5.12
Van-der-waals ICL2 F 690 - G.H5 T 341 G.H5.12
Hydrophobic C-term I 853 - G.H5 L 349 G.H5.20
Van-der-waals C-term I 853 - G.H5 L 349 G.H5.20
Polar TM3 L 686 3x56 G.H5 N 348 G.H5.19
Hydrophobic TM3 L 686 3x56 G.H5 N 348 G.H5.19
Van-der-waals TM3 L 686 3x56 G.H5 N 348 G.H5.19
Hydrophobic C-term V 861 - G.H5 T 341 G.H5.12
Hydrophobic ICL1 K 625 12x51 G.H5 L 354 G.H5.25
Van-der-waals ICL1 K 625 12x51 G.H5 L 354 G.H5.25
Polar ICL2 K 699 - G.H5 Y 351 G.H5.22
Aromatic ICL2 K 699 - G.H5 Y 351 G.H5.22
Hydrophobic ICL2 K 699 - G.H5 Y 351 G.H5.22
Hydrophobic TM3 L 686 3x56 G.H5 Y 351 G.H5.22
Polar C-term S 857 - G.H5 D 342 G.H5.13
Van-der-waals C-term S 857 - G.H5 D 342 G.H5.13