Gi2 - GPR12 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 142 3x54 G.H5 N 348 G.H5.19
Polar TM3 S 141 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 S 141 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 S 141 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM5 I 231 5x72 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM5 I 231 5x72 G.h4s6 E 319 G.h4s6.12
Hydrophobic C-term S 330 - G.H3 W 259 G.H3.17
Hydrophobic TM2 M 79 2x39 G.H5 D 351 G.H5.22
Van-der-waals TM2 M 79 2x39 G.H5 D 351 G.H5.22
Hydrophobic TM6 T 245 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 T 245 6x29 G.H5 F 355 G.H5.26
Hydrophobic C-term V 334 - G.H2 I 213 G.H2.08
Polar TM5 H 235 5x76 G.S6 I 320 G.S6.01
Hydrophobic TM5 H 235 5x76 G.S6 I 320 G.S6.01
Van-der-waals TM5 H 235 5x76 G.S6 I 320 G.S6.01
Hydrophobic ICL2 A 145 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 A 145 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM3 L 142 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 L 142 3x54 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 146 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 L 146 34x51 G.H5 F 337 G.H5.08
Hydrophobic TM4 V 154 4x39 G.HN R 24 G.HN.48
Van-der-waals TM4 V 154 4x39 G.HN R 24 G.HN.48
Hydrophobic TM3 L 142 3x54 G.H5 I 345 G.H5.16
Hydrophobic ICL2 T 147 34x52 G.s2s3 D 194 G.s2s3.02
Hydrophobic TM5 V 224 5x65 G.H5 L 349 G.H5.20
Van-der-waals TM5 V 224 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 146 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 146 34x51 G.H5 I 344 G.H5.15
Polar TM6 G 249 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 G 249 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 G 249 6x33 G.H5 L 354 G.H5.25
Polar TM3 S 141 3x53 G.H5 C 352 G.H5.23
Ionic TM5 H 227 5x68 G.H5 D 342 G.H5.13
Polar TM5 H 227 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 H 227 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 H 227 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 Q 234 5x75 G.S6 Y 321 G.S6.02
Van-der-waals TM5 Q 234 5x75 G.S6 Y 321 G.S6.02
Polar ICL2 A 145 34x50 G.H5 N 348 G.H5.19
Hydrophobic ICL2 A 145 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 A 145 34x50 G.H5 I 344 G.H5.15
Hydrophobic ICL2 L 146 34x51 G.H5 T 341 G.H5.12
Ionic TM5 H 235 5x76 G.h4s6 E 319 G.h4s6.12
Polar TM5 H 235 5x76 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM5 H 235 5x76 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM5 H 235 5x76 G.h4s6 E 319 G.h4s6.12
Polar TM6 K 248 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM6 K 248 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 K 248 6x32 G.H5 F 355 G.H5.26
Polar ICL2 S 150 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 S 150 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 S 150 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 L 253 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 253 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM5 H 227 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 H 227 5x68 G.H5 I 345 G.H5.16
Polar TM3 R 138 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 C 352 G.H5.23
Hydrophobic ICL2 E 151 - G.HN E 25 G.HN.49
Van-der-waals ICL2 E 151 - G.HN E 25 G.HN.49
Hydrophobic TM5 I 220 5x61 G.H5 L 354 G.H5.25
Ionic C-term R 327 - G.h3s5 D 262 G.h3s5.02
Polar C-term R 327 - G.h3s5 D 262 G.h3s5.02
Van-der-waals C-term R 327 - G.h3s5 D 262 G.h3s5.02
Hydrophobic C-term R 329 - G.H3 W 259 G.H3.17
Van-der-waals C-term R 329 - G.H3 W 259 G.H3.17
Hydrophobic TM2 M 79 2x39 G.H5 C 352 G.H5.23
Hydrophobic ICL2 L 146 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 146 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM5 I 231 5x72 G.H5 D 342 G.H5.13
Hydrophobic C-term P 331 - G.H3 W 259 G.H3.17
Hydrophobic ICL2 S 150 - G.HN E 28 G.HN.52
Polar ICL2 H 149 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 H 149 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 H 149 - G.hns1 A 31 G.hns1.02
Polar H8 N 305 8x47 G.H5 D 351 G.H5.22
Polar ICL2 E 151 - G.HN E 28 G.HN.52
Hydrophobic ICL2 E 151 - G.HN E 28 G.HN.52
Van-der-waals ICL2 E 151 - G.HN E 28 G.HN.52
Ionic TM6 H 242 6x26 G.h4s6 E 319 G.h4s6.12
Polar TM6 H 242 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 H 242 6x26 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 H 242 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic C-term P 331 - G.H2 I 213 G.H2.08
Van-der-waals C-term P 331 - G.H2 I 213 G.H2.08
Hydrophobic TM6 T 252 6x36 G.H5 L 354 G.H5.25