Gs - GPR18 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 R 218 - G.H5 R 380 G.H5.12
Hydrophobic ICL3 R 218 - G.H5 R 380 G.H5.12
Van-der-waals ICL3 R 218 - G.H5 R 380 G.H5.12
Polar ICL2 K 133 34x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 K 133 34x57 G.H5 H 387 G.H5.19
Van-der-waals ICL2 K 133 34x57 G.H5 H 387 G.H5.19
Polar ICL2 K 133 34x57 G.H5 Q 390 G.H5.22
Van-der-waals ICL2 K 133 34x57 G.H5 Q 390 G.H5.22
Hydrophobic H8 Q 292 8x49 G.H5 R 389 G.H5.21
Van-der-waals H8 Q 292 8x49 G.H5 R 389 G.H5.21
Hydrophobic TM2 T 55 2x37 G.H5 Q 390 G.H5.22
Van-der-waals TM2 T 55 2x37 G.H5 Q 390 G.H5.22
Polar ICL3 T 219 - G.H5 Q 384 G.H5.16
Hydrophobic ICL3 T 219 - G.H5 Q 384 G.H5.16
Van-der-waals ICL3 T 219 - G.H5 Q 384 G.H5.16
Polar TM6 K 229 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 229 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 229 6x32 G.H5 L 394 G.H5.26
Polar TM6 L 222 6x25 G.H5 D 381 G.H5.13
Hydrophobic TM6 L 222 6x25 G.H5 D 381 G.H5.13
Van-der-waals TM6 L 222 6x25 G.H5 D 381 G.H5.13
Hydrophobic TM3 I 123 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 123 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM6 S 230 6x33 G.H5 L 388 G.H5.20
Polar ICL2 K 130 34x54 G.S1 H 41 G.S1.02
Aromatic ICL2 K 130 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 K 130 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 K 130 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 A 129 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 122 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 122 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM6 I 233 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 I 233 6x36 G.H5 L 393 G.H5.25
Polar H8 S 290 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 S 290 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 290 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM3 R 119 3x50 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 126 34x50 G.H5 I 383 G.H5.15
Polar TM6 S 230 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 230 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 230 6x33 G.H5 L 393 G.H5.25
Polar H8 K 291 8x48 G.H5 L 394 G.H5.26
Polar TM3 I 123 3x54 G.H5 Q 384 G.H5.16
Polar TM3 R 119 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 119 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 119 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 222 6x25 G.H5 L 388 G.H5.20
Polar ICL2 K 127 34x51 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 K 127 34x51 G.s2s3 D 215 G.s2s3.01
Ionic H8 R 296 8x53 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 123 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 123 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 K 127 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 K 127 34x51 G.S3 V 217 G.S3.01
Polar TM3 A 122 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 122 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 122 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 L 214 5x65 G.H5 L 388 G.H5.20
Polar TM2 T 56 2x38 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 237 6x40 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 126 34x50 G.H5 H 387 G.H5.19
Polar TM3 D 118 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 118 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 118 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM6 I 234 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM7 Y 287 7x54 G.H5 E 392 G.H5.24
Van-der-waals TM7 Y 287 7x54 G.H5 E 392 G.H5.24
Hydrophobic TM2 V 57 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 V 57 2x39 G.H5 Y 391 G.H5.23
Polar ICL2 K 130 34x54 G.S1 T 40 G.S1.01
Van-der-waals ICL2 K 130 34x54 G.S1 T 40 G.S1.01
Polar ICL2 K 133 34x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 K 133 34x57 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 K 133 34x57 G.H5 Y 391 G.H5.23
Polar ICL2 K 133 34x57 G.hns1 R 38 G.hns1.02
Hydrophobic TM6 K 223 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM6 K 223 6x26 G.H5 R 385 G.H5.17
Hydrophobic H8 F 293 8x50 G.H5 E 392 G.H5.24
Van-der-waals H8 F 293 8x50 G.H5 E 392 G.H5.24
Hydrophobic H8 Q 292 8x49 G.H5 Q 390 G.H5.22
Polar ICL2 K 130 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 K 130 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 K 130 34x54 G.hns1 R 38 G.hns1.02
Ionic ICL3 R 218 - G.s2s3 D 215 G.s2s3.01
Hydrophobic TM6 V 226 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 V 226 6x29 G.H5 L 394 G.H5.26
Polar TM6 K 221 6x24 G.H5 N 377 G.H5.09
Hydrophobic TM6 K 221 6x24 G.H5 N 377 G.H5.09
Van-der-waals TM6 K 221 6x24 G.H5 N 377 G.H5.09
Hydrophobic TM6 L 222 6x25 G.H5 R 385 G.H5.17
Van-der-waals TM6 L 222 6x25 G.H5 R 385 G.H5.17
Polar ICL2 K 130 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 K 130 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic TM6 K 221 6x24 G.H5 D 381 G.H5.13
Van-der-waals TM6 K 221 6x24 G.H5 D 381 G.H5.13