GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 75.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 13.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | P | 170 | 34x50 | G.H5 | L | 349 | G.H5.16 |
Aromatic | C-term | F | 393 | - | G.H2 | H | 218 | G.H2.09 |
Hydrophobic | C-term | F | 393 | - | G.H2 | H | 218 | G.H2.09 |
Van-der-waals | C-term | F | 393 | - | G.H2 | H | 218 | G.H2.09 |
Polar | ICL2 | K | 174 | - | G.hns1 | R | 37 | G.hns1.02 |
Ionic | TM4 | E | 178 | 4x40 | G.HN | R | 30 | G.HN.48 |
Polar | TM4 | E | 178 | 4x40 | G.HN | R | 30 | G.HN.48 |
Van-der-waals | TM4 | E | 178 | 4x40 | G.HN | R | 30 | G.HN.48 |
Hydrophobic | TM3 | I | 167 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | I | 167 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Polar | C-term | S | 375 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | S | 375 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | S | 375 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | TM6 | T | 270 | 6x29 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | V | 372 | - | G.H2 | W | 216 | G.H2.07 |
Polar | C-term | W | 404 | - | G.S2 | P | 193 | G.S2.05 |
Hydrophobic | C-term | W | 404 | - | G.S2 | P | 193 | G.S2.05 |
Van-der-waals | C-term | W | 404 | - | G.S2 | P | 193 | G.S2.05 |
Polar | ICL2 | P | 170 | 34x50 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL3 | V | 260 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | ICL3 | V | 260 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | TM3 | I | 167 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | I | 167 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Polar | C-term | G | 373 | - | G.H3 | Y | 261 | G.H3.15 |
Polar | C-term | N | 370 | - | G.H3 | E | 250 | G.H3.04 |
Hydrophobic | C-term | N | 370 | - | G.H3 | E | 250 | G.H3.04 |
Van-der-waals | C-term | N | 370 | - | G.H3 | E | 250 | G.H3.04 |
Polar | C-term | Y | 358 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Hydrophobic | C-term | Y | 358 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Van-der-waals | C-term | Y | 358 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Hydrophobic | C-term | V | 372 | - | G.H3 | T | 257 | G.H3.11 |
Polar | TM6 | T | 263 | 6x22 | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | TM6 | T | 263 | 6x22 | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | TM6 | T | 263 | 6x22 | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | TM3 | R | 163 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL3 | V | 260 | - | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | ICL3 | V | 260 | - | G.S6 | Y | 325 | G.S6.02 |
Polar | C-term | V | 372 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | V | 372 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | TM6 | M | 264 | 6x23 | G.H4 | V | 314 | G.H4.16 |
Ionic | ICL3 | R | 262 | - | G.H5 | D | 346 | G.H5.13 |
Polar | ICL3 | R | 262 | - | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | ICL3 | R | 262 | - | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | ICL3 | R | 262 | - | G.H5 | D | 346 | G.H5.13 |
Ionic | TM4 | E | 178 | 4x40 | G.HN | R | 34 | G.HN.52 |
Polar | TM4 | E | 178 | 4x40 | G.HN | R | 34 | G.HN.52 |
Polar | TM2 | T | 99 | 2x38 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | V | 372 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | V | 372 | - | G.H2 | R | 213 | G.H2.04 |
Polar | ICL3 | R | 261 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | ICL3 | R | 261 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | ICL3 | V | 260 | - | G.H5 | A | 342 | G.H5.09 |
Van-der-waals | ICL3 | V | 260 | - | G.H5 | A | 342 | G.H5.09 |
Polar | C-term | N | 412 | - | G.HN | Q | 28 | G.HN.46 |
Hydrophobic | ICL2 | S | 172 | 34x52 | G.S3 | I | 199 | G.S3.01 |
Polar | TM6 | T | 274 | 6x33 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM6 | T | 274 | 6x33 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | T | 274 | 6x33 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL2 | L | 171 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | L | 171 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Polar | TM6 | T | 274 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Polar | H8 | N | 334 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | N | 334 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | N | 334 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Polar | C-term | A | 403 | - | G.S2 | E | 191 | G.S2.03 |
Hydrophobic | ICL2 | L | 171 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | L | 171 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM3 | R | 163 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Polar | ICL2 | K | 174 | - | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL2 | K | 174 | - | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | ICL2 | K | 174 | - | G.H5 | N | 352 | G.H5.19 |
Polar | C-term | N | 370 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | C-term | F | 393 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | ICL3 | R | 262 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | C-term | V | 372 | - | G.H3 | L | 254 | G.H3.08 |
Hydrophobic | ICL2 | L | 171 | 34x51 | G.S3 | I | 199 | G.S3.01 |
Van-der-waals | ICL2 | L | 171 | 34x51 | G.S3 | I | 199 | G.S3.01 |
Van-der-waals | TM6 | F | 278 | 6x37 | G.H5 | Y | 356 | G.H5.23 |
Ionic | C-term | R | 395 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Polar | C-term | R | 395 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Van-der-waals | C-term | R | 395 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Hydrophobic | ICL2 | L | 171 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | ICL2 | L | 171 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | C-term | I | 406 | - | G.S3 | I | 200 | G.S3.02 |
Hydrophobic | TM6 | T | 263 | 6x22 | G.H4 | L | 310 | G.H4.12 |
Van-der-waals | TM6 | T | 263 | 6x22 | G.H4 | L | 310 | G.H4.12 |
Hydrophobic | ICL3 | R | 262 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Polar | TM6 | T | 263 | 6x22 | G.S6 | I | 324 | G.S6.01 |
Hydrophobic | TM6 | K | 271 | 6x30 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM5 | I | 250 | 5x65 | G.H5 | L | 353 | G.H5.20 |
Polar | TM2 | S | 98 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM2 | S | 98 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | S | 98 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Aromatic | C-term | W | 404 | - | G.S2 | Y | 192 | G.S2.04 |
Hydrophobic | C-term | W | 404 | - | G.S2 | Y | 192 | G.S2.04 |
Van-der-waals | C-term | W | 404 | - | G.S2 | Y | 192 | G.S2.04 |
Polar | TM3 | D | 162 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | D | 162 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | D | 162 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM6 | F | 278 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | A | 403 | - | G.S2 | Y | 192 | G.S2.04 |
Van-der-waals | C-term | A | 403 | - | G.S2 | Y | 192 | G.S2.04 |
Van-der-waals | ICL3 | R | 261 | - | G.S6 | F | 328 | G.S6.05 |
Hydrophobic | TM3 | I | 167 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | A | 403 | - | G.S2 | I | 190 | G.S2.02 |
Ionic | C-term | K | 369 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Polar | C-term | K | 369 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Van-der-waals | C-term | K | 369 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Hydrophobic | C-term | W | 404 | - | G.S2 | F | 194 | G.S2.06 |
Van-der-waals | C-term | W | 404 | - | G.S2 | F | 194 | G.S2.06 |
Ionic | ICL3 | R | 261 | - | G.H4 | E | 307 | G.H4.09 |
Polar | ICL3 | R | 261 | - | G.H4 | E | 307 | G.H4.09 |
Hydrophobic | ICL3 | R | 261 | - | G.H4 | E | 307 | G.H4.09 |
Van-der-waals | ICL3 | R | 261 | - | G.H4 | E | 307 | G.H4.09 |
Hydrophobic | C-term | L | 402 | - | G.S2 | P | 193 | G.S2.05 |
Hydrophobic | ICL2 | L | 171 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Van-der-waals | ICL2 | L | 171 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Ionic | TM6 | K | 271 | 6x30 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM4 | S | 176 | 4x38 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | TM4 | S | 176 | 4x38 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | P | 170 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | P | 170 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | TM5 | I | 253 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM5 | I | 253 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | C-term | W | 404 | - | G.H1 | R | 60 | G.H1.09 |
Van-der-waals | C-term | W | 404 | - | G.H1 | R | 60 | G.H1.09 |
Hydrophobic | TM6 | I | 275 | 6x34 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | I | 275 | 6x34 | G.H5 | L | 358 | G.H5.25 |
Polar | TM3 | T | 166 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | T | 166 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM6 | P | 268 | 6x27 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | P | 268 | 6x27 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | T | 263 | 6x22 | G.H4 | V | 314 | G.H4.16 |
Van-der-waals | TM6 | T | 263 | 6x22 | G.H4 | V | 314 | G.H4.16 |
Van-der-waals | C-term | K | 401 | - | G.S2 | I | 190 | G.S2.02 |
Polar | ICL2 | V | 175 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | V | 175 | - | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | V | 175 | - | G.hns1 | R | 37 | G.hns1.02 |
Polar | TM6 | T | 274 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | T | 274 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | T | 274 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | V | 372 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Polar | TM3 | T | 166 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | T | 166 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | T | 166 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM6 | T | 270 | 6x29 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | T | 270 | 6x29 | G.H5 | V | 359 | G.H5.26 |
Polar | H8 | N | 336 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | N | 336 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | I | 406 | - | G.S2 | P | 193 | G.S2.05 |
Van-der-waals | C-term | I | 406 | - | G.S2 | P | 193 | G.S2.05 |
Hydrophobic | ICL2 | K | 174 | - | G.H5 | I | 348 | G.H5.15 |
Polar | TM6 | N | 265 | 6x24 | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | TM6 | N | 265 | 6x24 | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | C-term | N | 370 | - | G.H3 | A | 253 | G.H3.07 |
Hydrophobic | ICL2 | P | 170 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM2 | T | 100 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | T | 100 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL3 | R | 262 | - | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | M | 264 | 6x23 | G.h4s6 | N | 317 | G.h4s6.08 |
Van-der-waals | TM6 | M | 264 | 6x23 | G.h4s6 | N | 317 | G.h4s6.08 |
Polar | TM6 | K | 271 | 6x30 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | K | 271 | 6x30 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | K | 271 | 6x30 | G.H5 | Q | 350 | G.H5.17 |
Polar | C-term | K | 401 | - | G.S2 | E | 191 | G.S2.03 |
Polar | C-term | N | 370 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | N | 370 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | TM6 | K | 271 | 6x30 | G.H5 | L | 353 | G.H5.20 |