Gt1 - GPR19 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 72.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 S 172 34x52 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 S 172 34x52 G.hns1 R 28 G.hns1.03
Polar TM2 S 98 2x37 G.H5 D 346 G.H5.22
Hydrophobic TM2 S 98 2x37 G.H5 D 346 G.H5.22
Hydrophobic ICL2 P 170 34x50 G.H5 I 340 G.H5.16
Van-der-waals ICL2 P 170 34x50 G.H5 I 340 G.H5.16
Aromatic C-term W 404 - G.H3 H 240 G.H3.03
Hydrophobic C-term W 404 - G.H3 H 240 G.H3.03
Hydrophobic TM4 K 182 4x44 G.HN K 20 G.HN.48
Van-der-waals TM4 K 182 4x44 G.HN K 20 G.HN.48
Hydrophobic C-term F 393 - G.H3 I 249 G.H3.12
Hydrophobic ICL2 L 171 34x51 G.s2s3 K 188 G.s2s3.01
Van-der-waals ICL2 L 171 34x51 G.s2s3 K 188 G.s2s3.01
Hydrophobic ICL1 R 95 12x49 G.h3s5 A 256 G.h3s5.01
Hydrophobic TM6 T 263 6x22 G.H5 A 334 G.H5.10
Ionic C-term R 395 - G.H3 E 241 G.H3.04
Polar C-term R 395 - G.H3 E 241 G.H3.04
Van-der-waals C-term R 395 - G.H3 E 241 G.H3.04
Hydrophobic ICL2 S 172 34x52 G.s2s3 D 189 G.s2s3.02
Van-der-waals ICL2 S 172 34x52 G.s2s3 D 189 G.s2s3.02
Hydrophobic TM4 E 178 4x40 G.HN K 20 G.HN.48
Van-der-waals TM4 E 178 4x40 G.HN K 20 G.HN.48
Hydrophobic C-term F 393 - G.h2s4 F 211 G.h2s4.01
Van-der-waals C-term F 393 - G.h2s4 F 211 G.h2s4.01
Polar ICL1 R 95 12x49 G.H3 Y 254 G.H3.17
Van-der-waals ICL1 R 95 12x49 G.H3 Y 254 G.H3.17
Hydrophobic TM6 P 268 6x27 G.H5 F 350 G.H5.26
Van-der-waals TM6 P 268 6x27 G.H5 F 350 G.H5.26
Hydrophobic C-term V 372 - G.H3 H 244 G.H3.07
Ionic C-term D 394 - G.H2 K 205 G.H2.05
Polar C-term D 394 - G.H2 K 205 G.H2.05
Hydrophobic C-term D 394 - G.H2 K 205 G.H2.05
Van-der-waals C-term D 394 - G.H2 K 205 G.H2.05
Hydrophobic TM6 N 265 6x24 G.h4s6 E 314 G.h4s6.12
Van-der-waals TM6 N 265 6x24 G.h4s6 E 314 G.h4s6.12
Hydrophobic C-term F 393 - G.H3 L 245 G.H3.08
Polar C-term S 392 - G.H3 S 248 G.H3.11
Van-der-waals C-term S 392 - G.H3 S 248 G.H3.11
Hydrophobic C-term W 404 - G.hgh4 P 284 G.hgh4.03
Van-der-waals C-term W 404 - G.hgh4 P 284 G.hgh4.03
Polar C-term T 361 - G.h4s6 M 308 G.h4s6.03
Polar TM6 T 274 6x33 G.H5 G 348 G.H5.24
Hydrophobic TM6 T 274 6x33 G.H5 G 348 G.H5.24
Van-der-waals TM6 T 274 6x33 G.H5 G 348 G.H5.24
Polar C-term N 370 - G.hgh4 D 285 G.hgh4.04
Hydrophobic C-term N 370 - G.hgh4 D 285 G.hgh4.04
Van-der-waals C-term N 370 - G.hgh4 D 285 G.hgh4.04
Hydrophobic TM6 T 270 6x29 G.H5 L 349 G.H5.25
Van-der-waals TM6 T 270 6x29 G.H5 L 349 G.H5.25
Hydrophobic ICL2 L 171 34x51 G.S3 L 190 G.S3.01
Van-der-waals ICL2 L 171 34x51 G.S3 L 190 G.S3.01
Aromatic C-term F 393 - G.H3 H 252 G.H3.15
Hydrophobic C-term F 393 - G.H3 H 252 G.H3.15
Hydrophobic TM3 T 166 3x53 G.H5 N 343 G.H5.19
Van-der-waals TM3 T 166 3x53 G.H5 N 343 G.H5.19
Van-der-waals C-term F 414 - H.HD E 141 H.HD.12
Polar C-term S 388 - G.H3 R 253 G.H3.16
Van-der-waals C-term Y 358 - G.H3 R 253 G.H3.16
Polar TM2 T 100 2x39 G.H5 D 346 G.H5.22
Van-der-waals TM2 T 100 2x39 G.H5 D 346 G.H5.22
Hydrophobic C-term I 389 - G.H3 H 252 G.H3.15
Hydrophobic TM4 S 176 4x38 G.HN E 24 G.HN.52
Van-der-waals TM4 S 176 4x38 G.HN E 24 G.HN.52
Hydrophobic C-term F 393 - G.H2 R 204 G.H2.04
Polar C-term S 392 - G.H3 H 252 G.H3.15
Hydrophobic TM6 P 268 6x27 G.H5 K 341 G.H5.17
Van-der-waals TM6 P 268 6x27 G.H5 K 341 G.H5.17
Hydrophobic TM6 T 263 6x22 G.S6 H 318 G.S6.04
Van-der-waals TM6 T 263 6x22 G.S6 H 318 G.S6.04
Hydrophobic TM6 F 278 6x37 G.H5 C 347 G.H5.23
Van-der-waals TM6 F 278 6x37 G.H5 C 347 G.H5.23
Hydrophobic TM3 I 167 3x54 G.H5 L 344 G.H5.20
Van-der-waals TM3 I 167 3x54 G.H5 L 344 G.H5.20
Van-der-waals C-term V 372 - G.H3 N 247 G.H3.10
Polar TM3 R 163 3x50 G.H5 D 346 G.H5.22
Hydrophobic TM3 R 163 3x50 G.H5 D 346 G.H5.22
Van-der-waals TM3 R 163 3x50 G.H5 D 346 G.H5.22
Hydrophobic TM6 K 271 6x30 G.H5 F 350 G.H5.26
Van-der-waals TM6 K 271 6x30 G.H5 F 350 G.H5.26
Hydrophobic ICL3 V 260 - G.H5 D 337 G.H5.13
Van-der-waals ICL3 V 260 - G.H5 D 337 G.H5.13
Polar C-term A 357 - G.h4s6 R 309 G.h4s6.04
Hydrophobic C-term A 357 - G.h4s6 R 309 G.h4s6.04
Van-der-waals C-term A 357 - G.h4s6 R 309 G.h4s6.04
Polar C-term Y 358 - G.h4s6 R 309 G.h4s6.04
Aromatic C-term Y 358 - G.h4s6 R 309 G.h4s6.04
Hydrophobic C-term Y 358 - G.h4s6 R 309 G.h4s6.04
Van-der-waals C-term Y 358 - G.h4s6 R 309 G.h4s6.04
Hydrophobic C-term F 393 - G.H2 W 207 G.H2.07
Hydrophobic C-term F 414 - H.HA L 87 H.HA.29
Polar C-term G 373 - G.H3 H 244 G.H3.07
Hydrophobic TM6 T 270 6x29 G.H5 F 350 G.H5.26
Van-der-waals TM6 T 270 6x29 G.H5 F 350 G.H5.26
Polar ICL2 K 174 - G.H5 N 343 G.H5.19
Hydrophobic ICL2 K 174 - G.H5 N 343 G.H5.19
Van-der-waals ICL2 K 174 - G.H5 N 343 G.H5.19
Hydrophobic TM3 T 166 3x53 G.H5 C 347 G.H5.23
Van-der-waals TM3 T 166 3x53 G.H5 C 347 G.H5.23
Polar ICL1 R 95 12x49 G.H3 R 253 G.H3.16
Van-der-waals ICL1 R 95 12x49 G.H3 R 253 G.H3.16
Aromatic ICL3 R 262 - G.H5 F 330 G.H5.06
Hydrophobic ICL3 R 262 - G.H5 F 330 G.H5.06
Van-der-waals ICL3 R 262 - G.H5 F 330 G.H5.06
Hydrophobic C-term I 360 - G.h4s6 M 308 G.h4s6.03
Van-der-waals C-term I 360 - G.h4s6 M 308 G.h4s6.03
Hydrophobic C-term I 389 - G.H3 R 253 G.H3.16
Van-der-waals C-term I 389 - G.H3 R 253 G.H3.16
Hydrophobic TM6 I 275 6x34 G.H5 L 349 G.H5.25
Van-der-waals TM6 I 275 6x34 G.H5 L 349 G.H5.25
Hydrophobic C-term R 395 - G.H2 R 201 G.H2.01
Van-der-waals C-term R 395 - G.H2 R 201 G.H2.01
Hydrophobic ICL2 L 171 34x51 G.H5 T 336 G.H5.12
Ionic TM4 K 179 4x41 G.HN E 24 G.HN.52
Polar TM4 K 179 4x41 G.HN E 24 G.HN.52
Hydrophobic TM4 K 179 4x41 G.HN E 24 G.HN.52
Van-der-waals TM4 K 179 4x41 G.HN E 24 G.HN.52
Polar TM6 T 263 6x22 G.H5 D 337 G.H5.13
Hydrophobic C-term I 389 - G.H2 I 208 G.H2.08
Van-der-waals C-term I 389 - G.H2 I 208 G.H2.08
Polar TM3 R 163 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM3 R 163 3x50 G.H5 C 347 G.H5.23
Van-der-waals TM3 R 163 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM4 E 178 4x40 G.HN A 23 G.HN.51
Hydrophobic TM3 I 167 3x54 G.H5 L 349 G.H5.25
Van-der-waals TM3 I 167 3x54 G.H5 L 349 G.H5.25
Polar ICL2 P 170 34x50 G.H5 N 343 G.H5.19
Van-der-waals ICL2 P 170 34x50 G.H5 N 343 G.H5.19
Hydrophobic TM3 I 167 3x54 G.H5 C 347 G.H5.23
Polar TM6 N 265 6x24 G.S6 I 315 G.S6.01
Van-der-waals TM6 N 265 6x24 G.S6 I 315 G.S6.01
Hydrophobic TM6 K 271 6x30 G.H5 L 344 G.H5.20
Van-der-waals TM6 K 271 6x30 G.H5 L 344 G.H5.20
Hydrophobic TM6 T 263 6x22 G.S6 Y 316 G.S6.02
Van-der-waals TM6 T 263 6x22 G.S6 Y 316 G.S6.02
Hydrophobic TM4 S 176 4x38 G.hns1 A 27 G.hns1.02
Polar TM6 T 274 6x33 G.H5 L 349 G.H5.25
Hydrophobic TM6 T 274 6x33 G.H5 L 349 G.H5.25
Van-der-waals TM6 T 274 6x33 G.H5 L 349 G.H5.25
Hydrophobic TM4 S 176 4x38 G.HN A 23 G.HN.51
Polar TM6 K 271 6x30 G.H5 L 349 G.H5.25
Hydrophobic TM6 K 271 6x30 G.H5 L 349 G.H5.25
Van-der-waals TM6 K 271 6x30 G.H5 L 349 G.H5.25
Van-der-waals C-term T 359 - G.h4s6 M 308 G.h4s6.03
Hydrophobic C-term I 389 - G.H3 Y 254 G.H3.17
Van-der-waals C-term I 389 - G.H3 Y 254 G.H3.17
Hydrophobic TM6 V 267 6x26 G.H5 F 350 G.H5.26
Van-der-waals TM6 V 267 6x26 G.H5 F 350 G.H5.26
Hydrophobic C-term Y 390 - G.H2 I 208 G.H2.08
Van-der-waals C-term Y 390 - G.H2 I 208 G.H2.08
Hydrophobic C-term W 404 - G.hgh4 F 283 G.hgh4.02
Hydrophobic ICL2 K 174 - G.hns1 A 27 G.hns1.02
Van-der-waals ICL2 K 174 - G.hns1 A 27 G.hns1.02