G12 - GPR22 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 74.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic ICL3 R 296 - G.H4 D 336 G.H4.16
Polar ICL3 R 296 - G.H4 D 336 G.H4.16
Van-der-waals ICL3 R 296 - G.H4 D 336 G.H4.16
Hydrophobic ICL2 A 148 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 A 148 34x51 G.S3 I 221 G.S3.01
Polar H8 Q 372 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 Q 372 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 Q 372 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM5 R 241 5x68 G.H5 K 367 G.H5.12
Van-der-waals TM5 R 241 5x68 G.H5 K 367 G.H5.12
Hydrophobic TM5 F 246 5x73 G.S6 H 349 G.S6.04
Van-der-waals TM5 F 246 5x73 G.S6 H 349 G.S6.04
Van-der-waals TM6 R 307 6x29 G.H5 Q 381 G.H5.26
Hydrophobic C-term L 426 - H.HA K 114 H.HA.28
Van-der-waals C-term L 426 - H.HA K 114 H.HA.28
Hydrophobic ICL3 K 253 - G.H4 R 329 G.H4.09
Hydrophobic H8 R 371 8x47 G.H5 I 378 G.H5.23
Hydrophobic TM4 T 153 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 T 153 4x38 G.hns1 R 56 G.hns1.03
Polar TM7 T 370 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM7 T 370 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 T 370 7x56 G.H5 L 380 G.H5.25
Polar C-term V 427 - H.HA K 114 H.HA.28
Hydrophobic C-term V 427 - H.HA K 114 H.HA.28
Van-der-waals C-term V 427 - H.HA K 114 H.HA.28
Hydrophobic ICL2 P 147 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 147 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM6 V 311 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 311 6x33 G.H5 M 379 G.H5.24
Polar ICL3 R 300 - G.S6 L 346 G.S6.01
Polar C-term L 426 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term L 426 - H.HA L 115 H.HA.29
Van-der-waals C-term L 426 - H.HA L 115 H.HA.29
Hydrophobic TM5 R 241 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 241 5x68 G.H5 D 368 G.H5.13
Hydrophobic C-term F 416 - G.hgh4 P 315 G.hgh4.03
Polar H8 Q 372 8x48 G.H5 K 376 G.H5.21
Hydrophobic ICL2 P 147 34x50 G.H5 L 371 G.H5.16
Polar TM3 I 143 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 I 143 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 I 143 3x53 G.H5 N 374 G.H5.19
Polar ICL2 R 150 34x53 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 150 34x53 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 N 149 34x52 G.S3 I 221 G.S3.01
Hydrophobic ICL3 G 249 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 G 249 - G.H4 R 329 G.H4.09
Polar TM6 R 307 6x29 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM4 M 154 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 M 154 4x39 G.HN R 52 G.HN.52
Van-der-waals C-term P 428 - H.HA D 110 H.HA.24
Hydrophobic TM5 R 241 5x68 G.H5 L 371 G.H5.16
Polar TM2 N 74 2x36 G.hns1 R 55 G.hns1.02
Hydrophobic TM2 N 74 2x36 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 N 74 2x36 G.hns1 R 55 G.hns1.02
Polar ICL2 R 150 34x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 150 34x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 I 234 5x61 G.H5 M 379 G.H5.24
Van-der-waals TM5 I 234 5x61 G.H5 M 379 G.H5.24
Polar TM6 R 307 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 307 6x29 G.H5 Q 372 G.H5.17
Hydrophobic C-term W 405 - G.H3 I 280 G.H3.12
Van-der-waals C-term W 405 - G.H3 I 280 G.H3.12
Hydrophobic C-term W 405 - G.H3 N 283 G.H3.15
Van-der-waals C-term W 405 - G.H3 N 283 G.H3.15
Polar C-term P 428 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term P 428 - G.s4h3 R 265 G.s4h3.12
Aromatic TM5 F 246 5x73 G.S6 H 348 G.S6.03
Hydrophobic TM5 F 246 5x73 G.S6 H 348 G.S6.03
Van-der-waals TM5 F 246 5x73 G.S6 H 348 G.S6.03
Hydrophobic TM5 L 238 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 238 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 A 148 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL2 P 147 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 147 34x50 G.H5 I 370 G.H5.15
Ionic H8 K 373 8x49 G.H5 D 377 G.H5.22
Polar H8 K 373 8x49 G.H5 D 377 G.H5.22
Hydrophobic H8 K 373 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 K 373 8x49 G.H5 D 377 G.H5.22
Hydrophobic C-term P 428 - H.HA K 114 H.HA.28
Van-der-waals C-term P 428 - H.HA K 114 H.HA.28
Aromatic TM5 F 246 5x73 G.H5 F 361 G.H5.06
Hydrophobic TM5 F 246 5x73 G.H5 F 361 G.H5.06
Van-der-waals TM5 F 246 5x73 G.H5 F 361 G.H5.06
Hydrophobic C-term I 406 - G.H2 Q 236 G.H2.05
Hydrophobic TM3 S 144 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 S 144 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM3 R 140 3x50 G.H5 I 378 G.H5.23
Polar TM3 R 140 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM6 M 314 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 M 314 6x36 G.H5 L 380 G.H5.25
Polar TM3 V 145 3x55 G.H5 K 367 G.H5.12
Hydrophobic TM5 I 234 5x61 G.H5 L 375 G.H5.20
Hydrophobic H8 R 371 8x47 G.H5 D 377 G.H5.22
Van-der-waals H8 R 371 8x47 G.H5 D 377 G.H5.22
Polar ICL2 P 147 34x50 G.H5 N 374 G.H5.19
Van-der-waals TM6 R 310 6x32 G.H5 Q 381 G.H5.26
Hydrophobic C-term W 405 - G.H3 T 279 G.H3.11
Van-der-waals C-term W 405 - G.H3 T 279 G.H3.11
Ionic ICL3 R 300 - G.H4 D 336 G.H4.16
Polar ICL3 R 300 - G.H4 D 336 G.H4.16
Van-der-waals C-term V 427 - G.s4h3 R 265 G.s4h3.12
Hydrophobic TM5 Y 231 5x58 G.H5 M 379 G.H5.24
Hydrophobic TM3 I 143 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 143 3x53 G.H5 I 378 G.H5.23
Ionic C-term D 433 - G.hfs2 K 209 G.hfs2.06
Polar C-term D 433 - G.hfs2 K 209 G.hfs2.06
Hydrophobic C-term D 433 - G.hfs2 K 209 G.hfs2.06
Van-der-waals C-term D 433 - G.hfs2 K 209 G.hfs2.06