G12 - GPR31 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 20.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 125 34x56 G.HN R 52 G.HN.52
Polar C-term P 314 - G.H3 K 284 G.H3.16
Hydrophobic C-term P 314 - G.H3 K 284 G.H3.16
Van-der-waals C-term P 314 - G.H3 K 284 G.H3.16
Hydrophobic TM3 V 116 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 116 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM3 V 116 3x54 G.H5 N 374 G.H5.19
Hydrophobic TM6 V 224 6x37 G.H5 I 378 G.H5.23
Aromatic C-term Y 318 - G.h4s6 R 340 G.h4s6.09
Hydrophobic C-term Y 318 - G.h4s6 R 340 G.h4s6.09
Van-der-waals C-term Y 318 - G.h4s6 R 340 G.h4s6.09
Hydrophobic TM6 R 219 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM3 V 116 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 116 3x54 G.H5 L 371 G.H5.16
Polar H8 S 286 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 286 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 286 8x47 G.H5 L 380 G.H5.25
Hydrophobic C-term Y 318 - G.H3 K 284 G.H3.16
Van-der-waals C-term Y 318 - G.H3 K 284 G.H3.16
Polar TM6 K 216 6x29 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 K 216 6x29 G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL2 K 122 34x53 G.hns1 R 56 G.hns1.03
Polar C-term S 317 - G.h4s6 R 340 G.h4s6.09
Van-der-waals C-term S 317 - G.h4s6 R 340 G.h4s6.09
Polar ICL2 L 126 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 L 204 5x65 G.H5 L 371 G.H5.16
Hydrophobic H8 P 287 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 P 287 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM2 L 53 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 L 53 2x43 G.H5 L 380 G.H5.25
Hydrophobic ICL2 R 120 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 R 120 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM2 Y 49 2x39 G.H5 L 380 G.H5.25
Van-der-waals TM2 Y 49 2x39 G.H5 L 380 G.H5.25
Hydrophobic TM6 L 217 6x30 G.H5 L 375 G.H5.20
Van-der-waals TM6 L 217 6x30 G.H5 L 375 G.H5.20
Polar TM7 S 285 7x56 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 P 119 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 119 34x50 G.H5 I 370 G.H5.15
Polar TM5 R 207 5x68 G.H5 K 367 G.H5.12
Hydrophobic TM5 R 207 5x68 G.H5 K 367 G.H5.12
Van-der-waals TM5 R 207 5x68 G.H5 K 367 G.H5.12
Hydrophobic TM7 Y 282 7x53 G.H5 L 380 G.H5.25
Polar TM3 R 115 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 R 115 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 R 115 3x53 G.H5 N 374 G.H5.19
Polar C-term Y 318 - G.H3 N 282 G.H3.14
Van-der-waals C-term Y 318 - G.H3 N 282 G.H3.14
Hydrophobic TM6 A 220 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM5 L 204 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 204 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM6 L 217 6x30 G.H5 L 371 G.H5.16
Ionic TM5 R 207 5x68 G.H5 D 368 G.H5.13
Polar TM5 R 207 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 207 5x68 G.H5 D 368 G.H5.13
Hydrophobic ICL2 K 122 34x53 G.HN R 52 G.HN.52
Hydrophobic TM7 S 285 7x56 G.H5 L 380 G.H5.25
Polar TM3 R 112 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 112 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 112 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM2 Y 49 2x39 G.H5 D 377 G.H5.22
Polar ICL2 L 125 34x56 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 L 125 34x56 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 L 125 34x56 G.hns1 R 55 G.hns1.02
Ionic TM3 R 115 3x53 G.H5 D 377 G.H5.22
Polar TM3 R 115 3x53 G.H5 D 377 G.H5.22
Hydrophobic TM3 R 115 3x53 G.H5 D 377 G.H5.22
Van-der-waals TM3 R 115 3x53 G.H5 D 377 G.H5.22
Hydrophobic TM6 A 220 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 A 220 6x33 G.H5 L 375 G.H5.20
Polar H8 S 286 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 S 286 8x47 G.H5 M 379 G.H5.24
Hydrophobic TM5 R 207 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 207 5x68 G.H5 L 371 G.H5.16
Ionic TM2 K 47 2x37 G.H5 D 377 G.H5.22
Polar TM2 K 47 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 K 47 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 K 47 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM7 S 285 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 S 285 7x56 G.H5 M 379 G.H5.24
Hydrophobic TM5 I 200 5x61 G.H5 I 378 G.H5.23
Polar ICL2 R 120 34x51 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 R 120 34x51 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 120 34x51 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 R 120 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 R 120 34x51 G.S3 I 221 G.S3.01