Gi1 - GPR33 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 87.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 N 63 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 N 63 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 N 63 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Q 137 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 Q 137 34x54 G.H5 I 343 G.H5.15
Hydrophobic H8 G 303 8x47 G.H5 G 352 G.H5.24
Polar ICL3 L 237 - G.H5 K 345 G.H5.17
Hydrophobic ICL3 L 237 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 L 237 - G.H5 K 345 G.H5.17
Polar ICL2 Q 138 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 138 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 138 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 Q 138 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 Q 138 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 Q 138 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 P 133 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 133 34x50 G.H5 I 343 G.H5.15
Ionic TM5 R 235 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 235 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 235 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 235 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM7 V 302 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 V 302 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM3 R 126 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL3 F 238 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 F 238 - G.H5 L 348 G.H5.20
Hydrophobic ICL2 V 134 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 134 34x51 G.S3 L 194 G.S3.01
Polar TM6 K 242 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 242 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 242 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 M 247 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 134 34x51 G.s2s3 D 193 G.s2s3.02
Ionic TM5 R 235 5x68 G.H5 D 337 G.H5.09
Polar TM5 R 235 5x68 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 235 5x68 G.H5 D 337 G.H5.09
Van-der-waals TM5 R 235 5x68 G.H5 D 337 G.H5.09
Hydrophobic ICL3 L 237 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 L 237 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 133 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 133 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM5 V 228 5x61 G.H5 L 348 G.H5.20
Ionic ICL3 K 239 - G.h4s6 D 315 G.h4s6.09
Polar ICL3 K 239 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 K 239 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 K 239 - G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 V 246 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 246 6x36 G.H5 L 353 G.H5.25
Polar ICL1 Q 60 - G.HN R 24 G.HN.48
Hydrophobic TM3 L 129 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 129 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM4 T 141 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 R 143 4x40 G.HN R 21 G.HN.45
Polar TM3 R 126 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 126 3x50 G.H5 C 351 G.H5.23
Polar TM2 N 63 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 63 2x39 G.H5 D 350 G.H5.22
Polar ICL2 Q 137 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 Q 137 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 Q 137 34x54 G.hns1 A 31 G.hns1.02
Polar H8 N 305 8x49 G.H5 D 350 G.H5.22
Polar ICL3 K 239 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL3 K 239 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 K 239 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL3 L 237 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 L 237 - G.H5 I 344 G.H5.16
Hydrophobic TM3 T 130 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 T 130 3x54 G.H5 I 344 G.H5.16
Aromatic ICL3 F 238 - G.H5 F 354 G.H5.26
Hydrophobic ICL3 F 238 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 F 238 - G.H5 F 354 G.H5.26
Polar TM3 L 129 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 129 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 129 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 V 134 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM5 V 232 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 V 232 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM4 P 142 4x39 G.HN R 24 G.HN.48
Van-der-waals TM4 P 142 4x39 G.HN R 24 G.HN.48
Hydrophobic ICL2 P 133 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 P 243 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 P 243 6x33 G.H5 L 353 G.H5.25