G12 - GPR62 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM7 L 293 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 L 293 7x56 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 121 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 121 - G.S3 I 221 G.S3.01
Hydrophobic ICL3 L 227 - G.H4 D 336 G.H4.16
Hydrophobic ICL2 P 123 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 P 123 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL3 H 216 - G.HG M 298 G.HG.01
Hydrophobic C-term L 326 - G.h2s4 F 242 G.h2s4.01
Van-der-waals C-term L 326 - G.h2s4 F 242 G.h2s4.01
Polar ICL3 S 217 - G.S6 H 349 G.S6.04
Hydrophobic ICL3 S 217 - G.S6 H 349 G.S6.04
Van-der-waals ICL3 S 217 - G.S6 H 349 G.S6.04
Hydrophobic ICL2 G 124 - G.hns1 R 56 G.hns1.03
Polar ICL3 L 224 - G.S6 H 349 G.S6.04
Hydrophobic ICL3 L 224 - G.S6 H 349 G.S6.04
Van-der-waals ICL3 L 224 - G.S6 H 349 G.S6.04
Hydrophobic ICL3 I 226 - G.h4s6 P 345 G.h4s6.20
Polar H8 R 298 8x51 G.H5 Q 381 G.H5.26
Van-der-waals H8 R 298 8x51 G.H5 Q 381 G.H5.26
Hydrophobic TM5 P 207 5x73 G.S6 F 347 G.S6.02
Polar ICL1 G 44 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL1 G 44 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 G 44 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 P 120 - G.H5 L 371 G.H5.16
Hydrophobic ICL3 H 216 - G.HG V 302 G.HG.05
Hydrophobic TM5 A 202 5x68 G.H5 L 371 G.H5.16
Polar ICL2 S 125 - G.hns1 R 56 G.hns1.03
Polar ICL3 S 217 - G.s6h5 D 355 G.s6h5.05
Van-der-waals ICL3 S 217 - G.s6h5 D 355 G.s6h5.05
Hydrophobic TM6 R 233 6x27 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 233 6x27 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 L 121 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 121 - G.H5 F 363 G.H5.08
Hydrophobic TM5 V 198 5x64 G.H5 L 371 G.H5.16
Hydrophobic ICL3 I 226 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 I 226 - G.S6 F 347 G.S6.02
Hydrophobic C-term L 330 - G.H3 T 279 G.H3.11
Polar ICL3 S 225 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 S 225 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 S 225 - G.S6 H 348 G.S6.03
Hydrophobic TM6 L 234 6x28 G.H5 Q 381 G.H5.26
Van-der-waals TM6 L 234 6x28 G.H5 Q 381 G.H5.26
Hydrophobic C-term L 327 - G.H2 F 239 G.H2.08
Ionic TM6 R 233 6x27 G.H5 D 368 G.H5.13
Polar TM6 R 233 6x27 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 233 6x27 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 233 6x27 G.H5 D 368 G.H5.13
Hydrophobic ICL3 P 229 - G.h4s6 P 345 G.h4s6.20
Hydrophobic C-term P 333 - G.H2 R 232 G.H2.01
Hydrophobic C-term C 329 - G.H3 T 279 G.H3.11
Hydrophobic TM5 I 195 5x61 G.H5 M 379 G.H5.24
Hydrophobic ICL3 S 217 - G.s6h5 T 351 G.s6h5.01
Hydrophobic TM3 I 117 3x54 G.H5 N 374 G.H5.19
Hydrophobic H8 P 296 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 P 296 8x49 G.H5 D 377 G.H5.22
Hydrophobic TM5 A 199 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM6 L 241 6x35 G.H5 L 380 G.H5.25
Hydrophobic C-term W 321 - G.H3 K 284 G.H3.16
Van-der-waals C-term W 321 - G.H3 K 284 G.H3.16
Hydrophobic TM2 R 46 2x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 R 46 2x38 G.hns1 R 55 G.hns1.02
Hydrophobic C-term L 326 - G.H3 N 283 G.H3.15
Van-der-waals C-term L 326 - G.H3 N 283 G.H3.15
Hydrophobic ICL2 L 121 - G.S1 V 58 G.S1.02
Hydrophobic ICL3 P 229 - G.h4s6 K 344 G.h4s6.19
Polar ICL3 R 223 - G.S6 H 349 G.S6.04
Hydrophobic ICL3 R 223 - G.S6 H 349 G.S6.04
Hydrophobic TM3 I 117 3x54 G.H5 L 375 G.H5.20
Hydrophobic C-term L 330 - G.H3 I 276 G.H3.08
Hydrophobic TM6 L 245 6x39 G.H5 L 380 G.H5.25
Van-der-waals TM6 L 245 6x39 G.H5 L 380 G.H5.25
Polar ICL3 L 227 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 L 227 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 L 227 - G.S6 H 348 G.S6.03
Hydrophobic TM6 A 242 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM3 L 116 3x53 G.H5 I 378 G.H5.23
Polar TM5 A 202 5x68 G.H5 Q 372 G.H5.17
Hydrophobic ICL3 L 224 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 L 224 - G.H5 F 361 G.H5.06
Hydrophobic ICL2 L 121 - G.H5 V 366 G.H5.11
Hydrophobic TM6 A 242 6x36 G.H5 L 380 G.H5.25
Van-der-waals H8 Q 294 8x47 G.H5 D 377 G.H5.22
Hydrophobic ICL2 R 122 - G.S3 I 221 G.S3.01
Hydrophobic C-term L 330 - G.H2 W 238 G.H2.07
Hydrophobic ICL3 S 217 - G.S6 F 350 G.S6.05
Van-der-waals ICL3 S 217 - G.S6 F 350 G.S6.05
Hydrophobic TM6 P 243 6x37 G.H5 M 379 G.H5.24
Van-der-waals TM6 P 243 6x37 G.H5 M 379 G.H5.24
Hydrophobic C-term P 334 - G.s4h3 T 267 G.s4h3.14
Polar H8 Q 294 8x47 G.H5 I 378 G.H5.23
Hydrophobic H8 Q 294 8x47 G.H5 I 378 G.H5.23
Van-der-waals H8 Q 294 8x47 G.H5 I 378 G.H5.23
Polar TM6 L 230 6x24 G.h4s6 R 342 G.h4s6.11
Hydrophobic TM6 L 230 6x24 G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL2 P 123 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 P 123 - G.hns1 R 56 G.hns1.03
Hydrophobic C-term W 321 - G.H3 N 283 G.H3.15
Van-der-waals C-term W 321 - G.H3 N 283 G.H3.15
Polar ICL3 R 223 - G.S6 F 350 G.S6.05
Hydrophobic ICL1 P 43 - G.HN A 48 G.HN.48
Hydrophobic TM3 I 117 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 117 3x54 G.H5 I 378 G.H5.23
Hydrophobic C-term L 327 - G.H2 Q 236 G.H2.05
Van-der-waals C-term L 327 - G.H2 Q 236 G.H2.05
Polar TM2 R 46 2x38 G.H5 N 374 G.H5.19
Hydrophobic TM2 R 46 2x38 G.H5 N 374 G.H5.19
Van-der-waals TM2 R 46 2x38 G.H5 N 374 G.H5.19
Hydrophobic TM5 A 202 5x68 G.H5 L 375 G.H5.20
Hydrophobic ICL3 I 226 - G.S6 H 348 G.S6.03
Polar TM3 L 116 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 L 116 3x53 G.H5 N 374 G.H5.19
Hydrophobic C-term L 326 - G.H3 T 279 G.H3.11
Van-der-waals C-term L 326 - G.H3 T 279 G.H3.11
Polar C-term L 330 - G.H2 R 235 G.H2.04
Hydrophobic C-term L 330 - G.H2 R 235 G.H2.04
Van-der-waals C-term L 330 - G.H2 R 235 G.H2.04
Hydrophobic TM3 I 117 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 117 3x54 G.H5 L 371 G.H5.16
Hydrophobic C-term P 323 - G.H2 F 239 G.H2.08
Hydrophobic ICL2 L 121 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 121 - G.H5 I 370 G.H5.15
Hydrophobic ICL2 P 120 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 120 - G.H5 K 367 G.H5.12
Hydrophobic ICL3 L 227 - G.H4 V 332 G.H4.12
Van-der-waals ICL3 L 227 - G.H4 V 332 G.H4.12
Polar C-term Q 331 - G.H2 Q 236 G.H2.05
Hydrophobic C-term Q 331 - G.H2 Q 236 G.H2.05
Van-der-waals C-term Q 331 - G.H2 Q 236 G.H2.05
Hydrophobic ICL2 L 121 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 L 121 - G.H5 K 367 G.H5.12
Hydrophobic TM5 A 199 5x65 G.H5 M 379 G.H5.24
Hydrophobic TM3 R 113 3x50 G.H5 I 378 G.H5.23
Polar ICL3 L 227 - G.S6 L 346 G.S6.01
Hydrophobic ICL3 L 227 - G.S6 L 346 G.S6.01
Van-der-waals ICL3 L 227 - G.S6 L 346 G.S6.01
Polar C-term Q 319 - G.H3 K 284 G.H3.16
Hydrophobic C-term L 327 - G.H2 R 235 G.H2.04
Hydrophobic TM6 L 234 6x28 G.H5 L 375 G.H5.20
Ionic H8 R 295 8x48 G.H5 D 377 G.H5.22
Polar H8 R 295 8x48 G.H5 D 377 G.H5.22
Hydrophobic H8 R 295 8x48 G.H5 D 377 G.H5.22
Hydrophobic TM6 A 239 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 239 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL3 P 229 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 P 229 - G.h4s6 S 343 G.h4s6.12
Hydrophobic TM5 P 207 5x73 G.H5 H 364 G.H5.09
Hydrophobic ICL2 P 120 - G.H5 I 370 G.H5.15