Gs - GPR63 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 74.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic H8 K 376 8x48 G.h4s6 R 356 G.h4s6.12
Van-der-waals H8 K 376 8x48 G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term I 404 - G.h2s4 D 240 G.h2s4.03
Van-der-waals C-term I 404 - G.h2s4 D 240 G.h2s4.03
Hydrophobic TM2 I 116 2x39 G.H5 L 393 G.H5.25
Van-der-waals TM2 I 116 2x39 G.H5 L 393 G.H5.25
Hydrophobic N-term N 16 - G.HN G 2 G.HN.02
Van-der-waals N-term N 16 - G.HN G 2 G.HN.02
Hydrophobic TM3 R 179 3x50 G.H5 L 388 G.H5.20
Hydrophobic TM4 P 192 4x39 G.hns1 R 38 G.hns1.02
Hydrophobic C-term R 403 - G.h2s4 N 239 G.h2s4.02
Hydrophobic ICL1 M 112 12x50 G.H5 E 392 G.H5.24
Van-der-waals ICL1 M 112 12x50 G.H5 E 392 G.H5.24
Hydrophobic TM6 F 308 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 F 308 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 309 6x30 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 309 6x30 G.H5 L 394 G.H5.26
Hydrophobic TM5 Y 279 5x75 G.hgh4 T 325 G.hgh4.15
Van-der-waals TM5 Y 279 5x75 G.hgh4 T 325 G.hgh4.15
Polar ICL3 L 285 - G.hgh4 E 322 G.hgh4.12
Hydrophobic ICL3 L 285 - G.hgh4 E 322 G.hgh4.12
Van-der-waals ICL3 L 285 - G.hgh4 E 322 G.hgh4.12
Hydrophobic C-term Y 410 - G.S2 I 207 G.S2.01
Polar C-term H 415 - G.hfs2 S 205 G.hfs2.06
Van-der-waals C-term H 415 - G.hfs2 S 205 G.hfs2.06
Polar C-term R 416 - G.hfs2 S 205 G.hfs2.06
Van-der-waals C-term R 416 - G.hfs2 S 205 G.hfs2.06
Polar C-term R 402 - G.h2s4 F 238 G.h2s4.01
Hydrophobic C-term R 402 - G.h2s4 F 238 G.h2s4.01
Van-der-waals C-term R 402 - G.h2s4 F 238 G.h2s4.01
Polar TM6 S 303 6x24 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 S 303 6x24 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 S 303 6x24 G.h4s6 Y 358 G.h4s6.20
Hydrophobic C-term R 402 - G.h3s5 I 285 G.h3s5.03
Van-der-waals C-term R 402 - G.h3s5 I 285 G.h3s5.03
Hydrophobic N-term G 13 - G.HN L 4 G.HN.10
Van-der-waals N-term G 13 - G.HN L 4 G.HN.10
Ionic ICL2 R 186 - G.H5 D 381 G.H5.13
Polar ICL2 R 186 - G.H5 D 381 G.H5.13
Hydrophobic ICL2 R 186 - G.H5 D 381 G.H5.13
Van-der-waals ICL2 R 186 - G.H5 D 381 G.H5.13
Hydrophobic TM6 A 312 6x33 G.H5 L 394 G.H5.26
Van-der-waals TM6 A 312 6x33 G.H5 L 394 G.H5.26
Hydrophobic TM4 P 192 4x39 G.HN Q 35 G.HN.52
Hydrophobic C-term P 406 - G.hns1 Y 37 G.hns1.01
Van-der-waals C-term P 406 - G.hns1 Y 37 G.hns1.01
Polar ICL1 A 110 12x48 G.HN K 34 G.HN.51
Van-der-waals ICL1 A 110 12x48 G.HN K 34 G.HN.51
Polar N-term T 14 - G.HN L 4 G.HN.10
Hydrophobic C-term C 412 - G.hfs2 G 206 G.hfs2.07
Polar TM4 K 196 4x43 G.HN Q 31 G.HN.48
Hydrophobic C-term R 402 - G.H3 L 282 G.H3.18
Van-der-waals C-term R 402 - G.H3 L 282 G.H3.18
Hydrophobic TM6 I 304 6x25 G.S6 Y 360 G.S6.02
Hydrophobic C-term K 401 - G.H3 W 281 G.H3.17
Van-der-waals C-term K 401 - G.H3 W 281 G.H3.17
Polar C-term C 412 - G.S2 I 207 G.S2.01
Hydrophobic C-term C 412 - G.S2 I 207 G.S2.01
Van-der-waals C-term C 412 - G.S2 I 207 G.S2.01
Ionic TM6 D 305 6x26 G.H5 R 389 G.H5.21
Polar TM6 D 305 6x26 G.H5 R 389 G.H5.21
Hydrophobic TM6 D 305 6x26 G.H5 R 389 G.H5.21
Van-der-waals TM6 D 305 6x26 G.H5 R 389 G.H5.21
Hydrophobic TM2 A 115 2x38 G.H5 L 393 G.H5.25
Polar C-term R 402 - G.H3 W 281 G.H3.17
Hydrophobic C-term R 402 - G.H3 W 281 G.H3.17
Van-der-waals C-term R 402 - G.H3 W 281 G.H3.17
Hydrophobic ICL2 D 188 - G.H5 L 388 G.H5.20
Van-der-waals ICL2 D 188 - G.H5 L 388 G.H5.20
Hydrophobic TM6 I 304 6x25 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 I 304 6x25 G.h4s6 Y 358 G.h4s6.20
Polar H8 K 377 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 K 377 8x49 G.H5 Q 390 G.H5.22
Hydrophobic C-term T 400 - G.H3 W 281 G.H3.17
Van-der-waals C-term T 400 - G.H3 W 281 G.H3.17
Hydrophobic ICL3 I 283 - G.hgh4 E 322 G.hgh4.12
Van-der-waals ICL3 I 283 - G.hgh4 E 322 G.hgh4.12
Polar N-term T 14 - G.HN G 2 G.HN.02
Hydrophobic N-term T 14 - G.HN G 2 G.HN.02
Van-der-waals N-term T 14 - G.HN G 2 G.HN.02
Hydrophobic TM3 I 182 3x53 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 182 3x53 G.H5 L 388 G.H5.20
Polar TM4 N 191 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM4 N 191 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 N 191 4x38 G.HN Q 35 G.HN.52
Polar TM3 R 179 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM3 R 179 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM3 R 179 3x50 G.H5 L 393 G.H5.25
Aromatic TM6 F 308 6x29 G.H5 R 389 G.H5.21
Hydrophobic TM6 F 308 6x29 G.H5 R 389 G.H5.21
Van-der-waals TM6 F 308 6x29 G.H5 R 389 G.H5.21
Polar ICL3 C 284 - G.hgh4 E 322 G.hgh4.12
Van-der-waals ICL3 C 284 - G.hgh4 E 322 G.hgh4.12
Hydrophobic TM6 K 309 6x30 G.H5 R 385 G.H5.17
Van-der-waals TM6 K 309 6x30 G.H5 R 385 G.H5.17
Hydrophobic TM4 Y 193 4x40 G.HN Q 35 G.HN.52
Van-der-waals TM4 Y 193 4x40 G.HN Q 35 G.HN.52
Polar C-term T 400 - G.H3 R 280 G.H3.16
Hydrophobic C-term T 400 - G.H3 R 280 G.H3.16
Van-der-waals C-term T 400 - G.H3 R 280 G.H3.16
Ionic H8 K 377 8x49 G.H5 E 392 G.H5.24
Polar H8 K 377 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 K 377 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 K 377 8x49 G.H5 E 392 G.H5.24
Polar N-term N 16 - G.HN C 3 G.HN.09
Hydrophobic N-term N 16 - G.HN C 3 G.HN.09
Van-der-waals N-term N 16 - G.HN C 3 G.HN.09
Hydrophobic TM3 R 179 3x50 G.H5 L 394 G.H5.26
Van-der-waals TM3 R 179 3x50 G.H5 L 394 G.H5.26
Hydrophobic N-term S 15 - G.HN C 3 G.HN.09
Van-der-waals N-term S 15 - G.HN C 3 G.HN.09
Polar N-term S 15 - G.HN G 2 G.HN.02
Hydrophobic N-term S 15 - G.HN G 2 G.HN.02
Van-der-waals N-term S 15 - G.HN G 2 G.HN.02
Hydrophobic C-term Y 410 - G.H2 Q 236 G.H2.09
Van-der-waals C-term Y 410 - G.H2 Q 236 G.H2.09
Polar TM2 S 114 2x37 G.H5 E 392 G.H5.24
Polar TM2 N 117 2x40 G.H5 E 392 G.H5.24
Hydrophobic TM2 N 117 2x40 G.H5 E 392 G.H5.24
Van-der-waals TM2 N 117 2x40 G.H5 E 392 G.H5.24
Hydrophobic TM2 S 114 2x37 G.hns1 R 38 G.hns1.02
Polar TM6 D 305 6x26 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 D 305 6x26 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 D 305 6x26 G.h4s6 Y 358 G.h4s6.20
Polar ICL1 R 113 12x51 G.hns1 R 38 G.hns1.02
Hydrophobic ICL1 R 113 12x51 G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 R 113 12x51 G.hns1 R 38 G.hns1.02
Hydrophobic TM3 I 183 3x54 G.H5 L 394 G.H5.26
Polar ICL2 R 186 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 R 186 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 R 186 - G.H5 Q 384 G.H5.16
Hydrophobic N-term T 14 - G.HN M 1 G.HN.01
Van-der-waals N-term T 14 - G.HN M 1 G.HN.01
Polar TM2 S 114 2x37 G.H5 Y 391 G.H5.23
Hydrophobic TM2 S 114 2x37 G.H5 Y 391 G.H5.23
Van-der-waals TM2 S 114 2x37 G.H5 Y 391 G.H5.23
Hydrophobic C-term H 399 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term H 399 - G.h3s5 R 283 G.h3s5.01
Polar C-term I 404 - G.h2s4 N 239 G.h2s4.02
Hydrophobic C-term I 404 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term I 404 - G.h2s4 N 239 G.h2s4.02
Polar N-term N 16 - G.HN M 1 G.HN.01
Hydrophobic N-term N 16 - G.HN M 1 G.HN.01
Van-der-waals N-term N 16 - G.HN M 1 G.HN.01
Hydrophobic H8 I 375 8x47 G.H5 E 392 G.H5.24
Hydrophobic N-term S 15 - G.HN M 1 G.HN.01
Van-der-waals N-term S 15 - G.HN M 1 G.HN.01
Hydrophobic TM2 I 116 2x39 G.H5 E 392 G.H5.24
Van-der-waals TM2 I 116 2x39 G.H5 E 392 G.H5.24
Polar ICL1 A 111 12x49 G.hns1 R 38 G.hns1.02
Hydrophobic TM2 S 114 2x37 G.H5 L 393 G.H5.25
Polar ICL1 A 110 12x48 G.hns1 R 38 G.hns1.02
Polar C-term H 399 - G.h4s6 R 356 G.h4s6.12
Aromatic C-term H 399 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term H 399 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term H 399 - G.h4s6 R 356 G.h4s6.12
Aromatic C-term R 416 - G.S2 F 208 G.S2.02
Hydrophobic C-term R 416 - G.S2 F 208 G.S2.02
Van-der-waals C-term R 416 - G.S2 F 208 G.S2.02
Polar C-term T 417 - G.hfs2 S 205 G.hfs2.06