G12 - GPR6 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 76.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 15.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 174 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 174 34x51 G.S3 I 221 G.S3.01
Hydrophobic H8 Q 334 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 Q 334 8x48 G.H5 Q 381 G.H5.26
Polar TM6 H 270 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 H 270 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 H 270 6x26 G.H5 Q 372 G.H5.17
Polar C-term S 356 - G.HN R 51 G.HN.51
Hydrophobic TM3 L 170 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM6 P 268 6x24 G.h4s6 R 342 G.h4s6.11
Van-der-waals TM6 P 268 6x24 G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL2 T 175 34x52 G.S3 I 221 G.S3.01
Van-der-waals ICL2 T 175 34x52 G.S3 I 221 G.S3.01
Hydrophobic ICL2 A 173 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM7 I 328 7x52 G.H5 L 380 G.H5.25
Van-der-waals TM7 I 328 7x52 G.H5 L 380 G.H5.25
Hydrophobic C-term P 359 - G.h2s4 F 242 G.h2s4.01
Van-der-waals C-term P 359 - G.h2s4 F 242 G.h2s4.01
Polar TM6 L 266 6x22 G.S6 L 346 G.S6.01
Polar TM6 T 280 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM6 T 280 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 280 6x36 G.H5 M 379 G.H5.24
Hydrophobic ICL2 A 173 34x50 G.H5 L 371 G.H5.16
Polar ICL2 R 179 34x56 G.HN R 49 G.HN.49
Hydrophobic ICL2 R 179 34x56 G.HN R 49 G.HN.49
Van-der-waals ICL2 R 179 34x56 G.HN R 49 G.HN.49
Hydrophobic TM6 L 266 6x22 G.H4 V 332 G.H4.12
Van-der-waals TM6 L 266 6x22 G.H4 V 332 G.H4.12
Hydrophobic ICL2 L 174 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 174 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL3 C 265 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 C 265 - G.h4s6 P 345 G.h4s6.20
Hydrophobic C-term S 358 - G.h2s4 D 243 G.h2s4.02
Van-der-waals C-term S 358 - G.h2s4 D 243 G.h2s4.02
Polar TM7 R 332 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM7 R 332 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 R 332 7x56 G.H5 L 380 G.H5.25
Hydrophobic ICL3 Q 263 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 Q 263 - G.S6 H 348 G.S6.03
Hydrophobic ICL2 Y 177 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 Y 177 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL3 C 265 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 C 265 - G.S6 F 347 G.S6.02
Hydrophobic ICL3 H 264 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 H 264 - G.H5 F 361 G.H5.06
Polar ICL2 S 178 34x55 G.hns1 R 55 G.hns1.02
Polar ICL3 H 264 - G.S6 H 348 G.S6.03
Aromatic ICL3 H 264 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 H 264 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 H 264 - G.S6 H 348 G.S6.03
Polar TM3 R 166 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 166 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 166 3x50 G.H5 I 378 G.H5.23
Polar ICL2 R 179 34x56 G.HN A 48 G.HN.48
Polar C-term P 359 - G.h2s4 D 243 G.h2s4.02
Hydrophobic C-term P 359 - G.h2s4 D 243 G.h2s4.02
Van-der-waals C-term P 359 - G.h2s4 D 243 G.h2s4.02
Hydrophobic C-term P 359 - G.H3 L 285 G.H3.17
Van-der-waals C-term P 359 - G.H3 L 285 G.H3.17
Hydrophobic TM7 Y 329 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 329 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 273 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 273 6x29 G.H5 M 379 G.H5.24
Hydrophobic TM2 M 107 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM3 R 166 3x50 G.H5 L 380 G.H5.25
Van-der-waals TM3 R 166 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM5 I 259 5x72 G.H5 D 368 G.H5.13
Polar TM3 S 169 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 169 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 169 3x53 G.H5 N 374 G.H5.19
Hydrophobic C-term V 362 - G.H3 L 285 G.H3.17
Van-der-waals ICL3 H 264 - G.S6 L 346 G.S6.01
Hydrophobic ICL2 L 174 34x51 G.H5 V 366 G.H5.11
Polar TM6 K 276 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 276 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 276 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 H 270 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 H 270 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 H 264 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 H 264 - G.S6 F 347 G.S6.02
Hydrophobic TM5 I 259 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 I 259 5x72 G.H5 Q 372 G.H5.17
Hydrophobic TM5 V 251 5x64 G.H5 L 371 G.H5.16
Polar ICL2 S 178 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 S 178 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 S 178 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 L 170 3x54 G.H5 N 374 G.H5.19
Hydrophobic TM3 L 170 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 170 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM5 H 255 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM6 A 267 6x23 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 A 267 6x23 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 L 266 6x22 G.H4 D 336 G.H4.16
Van-der-waals TM6 L 266 6x22 G.H4 D 336 G.H4.16
Polar ICL2 R 179 34x56 G.HN R 52 G.HN.52
Hydrophobic ICL2 R 179 34x56 G.HN R 52 G.HN.52
Van-der-waals ICL2 R 179 34x56 G.HN R 52 G.HN.52
Hydrophobic ICL3 C 265 - G.S6 L 346 G.S6.01
Hydrophobic ICL2 L 174 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 174 34x51 G.H5 F 363 G.H5.08
Polar TM3 R 166 3x50 G.H5 D 377 G.H5.22
Hydrophobic ICL2 L 174 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM3 L 170 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 170 3x54 G.H5 L 371 G.H5.16
Polar TM6 L 266 6x22 G.h4s6 R 339 G.h4s6.08
Ionic TM5 H 255 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 255 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 255 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 255 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM6 G 277 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 G 277 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM4 L 182 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 L 182 4x39 G.HN R 52 G.HN.52
Hydrophobic TM5 H 255 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 H 255 5x68 G.H5 L 371 G.H5.16
Hydrophobic C-term R 357 - G.H3 L 285 G.H3.17
Hydrophobic TM5 V 252 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 V 252 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 174 34x51 G.H5 K 367 G.H5.12
Polar ICL3 Q 262 - G.H5 D 368 G.H5.13
Polar ICL3 H 264 - G.S6 H 349 G.S6.04
Aromatic ICL3 H 264 - G.S6 H 349 G.S6.04
Hydrophobic ICL3 H 264 - G.S6 H 349 G.S6.04
Van-der-waals ICL3 H 264 - G.S6 H 349 G.S6.04
Polar ICL2 Y 177 34x54 G.H5 D 377 G.H5.22
Van-der-waals ICL2 Y 177 34x54 G.H5 D 377 G.H5.22
Polar C-term R 357 - G.H3 K 284 G.H3.16
Polar TM7 R 332 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 R 332 7x56 G.H5 M 379 G.H5.24
Hydrophobic TM6 L 281 6x37 G.H5 I 378 G.H5.23
Hydrophobic TM5 I 259 5x72 G.S6 F 347 G.S6.02