G15 - GPR75 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 70.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 I 326 6x40 G.H5 L 373 G.H5.25
Polar C-term Y 517 - G.H1 R 63 G.H1.09
Hydrophobic TM3 R 143 3x50 G.H5 Y 367 G.H5.19
Van-der-waals TM3 R 143 3x50 G.H5 Y 367 G.H5.19
Hydrophobic TM6 A 319 6x33 G.H5 L 374 G.H5.26
Polar ICL2 Q 151 - G.S3 T 202 G.S3.01
Van-der-waals ICL2 Q 151 - G.S3 T 202 G.S3.01
Polar H8 S 380 8x47 G.H5 N 372 G.H5.24
Hydrophobic H8 S 380 8x47 G.H5 N 372 G.H5.24
Van-der-waals H8 S 380 8x47 G.H5 N 372 G.H5.24
Hydrophobic TM3 M 146 3x53 G.H5 L 364 G.H5.16
Hydrophobic TM6 K 315 6x29 G.H5 L 374 G.H5.26
Van-der-waals TM6 K 315 6x29 G.H5 L 374 G.H5.26
Hydrophobic TM5 I 225 5x61 G.H5 L 373 G.H5.25
Hydrophobic C-term I 535 - G.H5 T 349 G.H5.01
Polar ICL2 N 153 - G.s2s3 K 201 G.s2s3.02
Van-der-waals ICL2 N 153 - G.s2s3 K 201 G.s2s3.02
Ionic TM7 R 378 7x55 G.H5 E 370 G.H5.22
Polar TM7 R 378 7x55 G.H5 E 370 G.H5.22
Van-der-waals TM7 R 378 7x55 G.H5 E 370 G.H5.22
Polar TM7 R 378 7x55 G.H5 N 372 G.H5.24
Hydrophobic TM7 R 378 7x55 G.H5 N 372 G.H5.24
Van-der-waals TM7 R 378 7x55 G.H5 N 372 G.H5.24
Polar TM6 N 310 6x24 G.H5 D 361 G.H5.13
Van-der-waals TM6 N 310 6x24 G.H5 D 361 G.H5.13
Hydrophobic TM6 L 311 6x25 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM6 L 311 6x25 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM6 C 323 6x37 G.H5 L 373 G.H5.25
Van-der-waals TM6 C 323 6x37 G.H5 L 373 G.H5.25
Polar ICL1 R 76 12x51 G.hns1 R 40 G.hns1.02
Van-der-waals ICL1 R 76 12x51 G.hns1 R 40 G.hns1.02
Polar TM6 K 315 6x29 G.h4s6 R 337 G.h4s6.19
Van-der-waals TM6 K 315 6x29 G.h4s6 R 337 G.h4s6.19
Polar TM6 K 315 6x29 G.h4s6 R 335 G.h4s6.17
Hydrophobic TM6 K 315 6x29 G.h4s6 R 335 G.h4s6.17
Van-der-waals TM6 K 315 6x29 G.h4s6 R 335 G.h4s6.17
Polar TM3 R 143 3x50 G.H5 I 371 G.H5.23
Hydrophobic TM3 R 143 3x50 G.H5 I 371 G.H5.23
Van-der-waals TM3 R 143 3x50 G.H5 I 371 G.H5.23
Hydrophobic TM3 V 147 3x54 G.H5 L 368 G.H5.20
Hydrophobic TM6 L 311 6x25 G.H5 L 374 G.H5.26
Polar TM7 S 377 7x54 G.H5 N 372 G.H5.24
Polar H8 A 381 8x48 G.H5 N 372 G.H5.24
Hydrophobic H8 A 381 8x48 G.H5 N 372 G.H5.24
Van-der-waals H8 A 381 8x48 G.H5 N 372 G.H5.24
Polar ICL3 I 309 - G.H5 D 361 G.H5.13
Hydrophobic ICL3 I 309 - G.H5 D 361 G.H5.13
Van-der-waals ICL3 I 309 - G.H5 D 361 G.H5.13
Hydrophobic C-term Y 517 - G.h1ha A 68 G.h1ha.02
Van-der-waals C-term Y 517 - G.h1ha A 68 G.h1ha.02
Hydrophobic TM3 V 147 3x54 G.H5 L 364 G.H5.16
Van-der-waals TM3 V 147 3x54 G.H5 L 364 G.H5.16
Hydrophobic TM5 L 229 5x65 G.H5 L 368 G.H5.20
Polar TM6 A 319 6x33 G.H5 L 373 G.H5.25
Hydrophobic TM6 A 319 6x33 G.H5 L 373 G.H5.25
Van-der-waals TM6 A 319 6x33 G.H5 L 373 G.H5.25
Polar TM6 T 322 6x36 G.H5 L 373 G.H5.25
Hydrophobic TM6 T 322 6x36 G.H5 L 373 G.H5.25
Van-der-waals TM6 T 322 6x36 G.H5 L 373 G.H5.25
Hydrophobic TM6 N 310 6x24 G.S6 F 340 G.S6.02
Van-der-waals TM6 N 310 6x24 G.S6 F 340 G.S6.02
Hydrophobic ICL3 A 308 - G.H5 K 357 G.H5.09
Van-der-waals TM6 K 318 6x32 G.h4s6 R 335 G.h4s6.17
Hydrophobic ICL3 S 307 - G.H5 R 360 G.H5.12
Van-der-waals ICL3 S 307 - G.H5 R 360 G.H5.12
Polar ICL1 K 74 12x49 G.hns1 R 40 G.hns1.02
Hydrophobic ICL3 I 309 - G.H5 L 364 G.H5.16
Van-der-waals ICL3 I 309 - G.H5 L 364 G.H5.16
Hydrophobic TM6 L 311 6x25 G.H5 L 368 G.H5.20
Hydrophobic TM3 M 146 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 M 146 3x53 G.H5 Y 367 G.H5.19
Polar TM3 H 142 3x49 G.H5 Y 367 G.H5.19
Van-der-waals TM3 H 142 3x49 G.H5 Y 367 G.H5.19
Polar TM6 N 310 6x24 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM6 N 310 6x24 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM6 N 310 6x24 G.h4s6 R 338 G.h4s6.20
Polar H8 R 384 8x51 G.H5 N 372 G.H5.24
Polar TM6 K 318 6x32 G.H5 L 374 G.H5.26
Hydrophobic TM6 K 318 6x32 G.H5 L 374 G.H5.26
Van-der-waals TM6 K 318 6x32 G.H5 L 374 G.H5.26
Hydrophobic ICL3 A 308 - G.H5 D 361 G.H5.13
Van-der-waals ICL3 A 308 - G.H5 D 361 G.H5.13