Gi2 - mGlu2 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL1 S 601 12x53 G.H5 L 354 G.H5.25
Van-der-waals H8 R 829 8x54 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 G 667 - G.s2s3 D 194 G.s2s3.02
Hydrophobic C-term F 835 - G.H5 D 338 G.H5.09
Van-der-waals C-term F 835 - G.H5 D 338 G.H5.09
Polar H8 H 828 8x53 G.H5 K 346 G.H5.17
Hydrophobic H8 H 828 8x53 G.H5 K 346 G.H5.17
Van-der-waals H8 H 828 8x53 G.H5 K 346 G.H5.17
Hydrophobic TM3 R 656 3x53 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 656 3x53 G.H5 L 354 G.H5.25
Hydrophobic TM3 I 660 3x57 G.H5 N 348 G.H5.19
Hydrophobic TM3 F 661 3x58 G.H5 I 345 G.H5.16
Van-der-waals TM3 F 661 3x58 G.H5 I 345 G.H5.16
Polar ICL1 A 600 12x52 G.H5 L 354 G.H5.25
Hydrophobic ICL1 A 600 12x52 G.H5 L 354 G.H5.25
Van-der-waals ICL1 A 600 12x52 G.H5 L 354 G.H5.25
Hydrophobic TM3 I 660 3x57 G.H5 L 349 G.H5.20
Hydrophobic ICL1 K 599 12x51 G.H5 G 353 G.H5.24
Van-der-waals ICL1 K 599 12x51 G.H5 G 353 G.H5.24
Polar ICL2 A 664 - G.H5 T 341 G.H5.12
Hydrophobic ICL2 A 664 - G.H5 T 341 G.H5.12
Van-der-waals ICL2 A 664 - G.H5 T 341 G.H5.12
Hydrophobic C-term T 857 - G.S2 F 192 G.S2.08
Hydrophobic TM6 F 756 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 F 756 6x33 G.H5 L 349 G.H5.20
Ionic ICL2 R 672 - G.HN E 28 G.HN.52
Polar ICL2 R 672 - G.HN E 28 G.HN.52
Hydrophobic ICL2 R 672 - G.HN E 28 G.HN.52
Van-der-waals ICL2 R 672 - G.HN E 28 G.HN.52
Ionic ICL2 R 670 - G.H5 D 351 G.H5.22
Polar ICL2 R 670 - G.H5 D 351 G.H5.22
Hydrophobic ICL2 R 670 - G.H5 D 351 G.H5.22
Van-der-waals ICL2 R 670 - G.H5 D 351 G.H5.22
Polar C-term C 859 - G.h1ha E 58 G.h1ha.01
Hydrophobic C-term C 859 - G.h1ha E 58 G.h1ha.01
Van-der-waals C-term C 859 - G.h1ha E 58 G.h1ha.01
Polar C-term G 861 - G.S2 H 189 G.S2.05
Hydrophobic C-term G 861 - G.S2 H 189 G.S2.05
Hydrophobic H8 P 831 8x56 G.S6 Y 321 G.S6.02
Van-der-waals H8 P 831 8x56 G.S6 Y 321 G.S6.02
Hydrophobic ICL2 A 668 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 A 668 - G.S3 L 195 G.S3.01
Polar C-term V 858 - G.S2 T 191 G.S2.07
Hydrophobic H8 V 826 8x51 G.H5 F 355 G.H5.26
Van-der-waals H8 V 826 8x51 G.H5 F 355 G.H5.26
Hydrophobic TM3 I 660 3x57 G.H5 I 345 G.H5.16
Polar TM3 R 656 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 656 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 656 3x53 G.H5 C 352 G.H5.23
Hydrophobic ICL2 G 667 - G.S3 L 195 G.S3.01
Polar C-term T 868 - G.hfs2 T 183 G.hfs2.06
Van-der-waals C-term T 868 - G.hfs2 T 183 G.hfs2.06
Polar C-term C 859 - G.H1 H 57 G.H1.12
Hydrophobic C-term C 859 - G.H1 H 57 G.H1.12
Van-der-waals C-term C 859 - G.H1 H 57 G.H1.12
Hydrophobic H8 H 828 8x53 G.h4s6 D 316 G.h4s6.09
Van-der-waals H8 H 828 8x53 G.h4s6 D 316 G.h4s6.09
Polar ICL1 K 599 12x51 G.H5 F 355 G.H5.26
Hydrophobic ICL1 K 599 12x51 G.H5 F 355 G.H5.26
Van-der-waals ICL1 K 599 12x51 G.H5 F 355 G.H5.26
Hydrophobic C-term C 859 - G.S2 F 190 G.S2.06
Van-der-waals C-term C 859 - G.S2 F 190 G.S2.06
Hydrophobic TM3 I 660 3x57 G.H5 C 352 G.H5.23
Hydrophobic TM4 P 676 4x29 G.H5 C 352 G.H5.23
Van-der-waals TM4 P 676 4x29 G.H5 C 352 G.H5.23
Hydrophobic TM3 F 661 3x58 G.H5 L 349 G.H5.20
Polar ICL2 Q 669 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 669 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 669 - G.hns1 R 32 G.hns1.03
Ionic H8 H 828 8x53 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 A 664 - G.H5 I 345 G.H5.16
Van-der-waals ICL2 A 664 - G.H5 I 345 G.H5.16
Hydrophobic ICL2 A 668 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 A 668 - G.H5 I 344 G.H5.15
Polar C-term C 859 - G.S2 T 191 G.S2.07
Hydrophobic C-term C 859 - G.S2 T 191 G.S2.07
Van-der-waals C-term C 859 - G.S2 T 191 G.S2.07
Hydrophobic ICL2 R 672 - G.HN R 24 G.HN.48
Van-der-waals ICL2 R 672 - G.HN R 24 G.HN.48
Hydrophobic H8 A 830 8x55 G.h4s6 E 319 G.h4s6.12
Van-der-waals H8 A 830 8x55 G.h4s6 E 319 G.h4s6.12
Hydrophobic C-term T 857 - G.S2 T 191 G.S2.07
Van-der-waals C-term T 857 - G.S2 T 191 G.S2.07
Hydrophobic ICL2 P 671 - G.H5 N 348 G.H5.19
Polar C-term T 857 - G.H1 H 57 G.H1.12
Hydrophobic C-term T 857 - G.H1 H 57 G.H1.12
Van-der-waals C-term T 857 - G.H1 H 57 G.H1.12
Hydrophobic TM2 G 602 2x35 G.H5 L 354 G.H5.25
Van-der-waals TM2 G 602 2x35 G.H5 L 354 G.H5.25
Polar H8 H 828 8x53 G.h4s6 T 317 G.h4s6.10
Hydrophobic H8 H 828 8x53 G.h4s6 T 317 G.h4s6.10
Hydrophobic ICL2 I 674 - G.H5 N 348 G.H5.19
Hydrophobic ICL1 K 599 12x51 G.H5 L 354 G.H5.25
Van-der-waals ICL1 K 599 12x51 G.H5 L 354 G.H5.25
Aromatic H8 H 828 8x53 G.H5 F 355 G.H5.26
Hydrophobic H8 H 828 8x53 G.H5 F 355 G.H5.26
Van-der-waals H8 H 828 8x53 G.H5 F 355 G.H5.26
Polar H8 P 831 8x56 G.h4s6 E 319 G.h4s6.12
Hydrophobic H8 P 831 8x56 G.h4s6 E 319 G.h4s6.12
Van-der-waals H8 P 831 8x56 G.h4s6 E 319 G.h4s6.12
Ionic C-term E 863 - G.H1 K 54 G.H1.09
Polar C-term E 863 - G.H1 K 54 G.H1.09
Van-der-waals ICL2 E 666 - G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 R 670 - G.hns1 A 31 G.hns1.02
Polar ICL2 I 674 - G.H5 C 352 G.H5.23
Hydrophobic ICL2 I 674 - G.H5 C 352 G.H5.23
Van-der-waals ICL2 I 674 - G.H5 C 352 G.H5.23
Polar ICL2 G 667 - G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 G 667 - G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 G 667 - G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 R 670 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 R 670 - G.H5 N 348 G.H5.19