Gi3 - mGlu3 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 C 665 3x53 G.H5 L 353 G.H5.25
Van-der-waals TM3 C 665 3x53 G.H5 L 353 G.H5.25
Van-der-waals TM4 P 685 4x29 G.H5 E 350 G.H5.22
Hydrophobic TM3 F 670 3x58 G.H5 I 344 G.H5.16
Van-der-waals TM3 F 670 3x58 G.H5 I 344 G.H5.16
Polar ICL2 R 679 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 679 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 679 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 A 677 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 A 677 - G.S3 L 194 G.S3.01
Polar ICL2 A 677 - G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 A 677 - G.s2s3 K 192 G.s2s3.01
Polar H8 H 837 8x53 G.h4s6 K 317 G.h4s6.11
Hydrophobic H8 H 837 8x53 G.h4s6 K 317 G.h4s6.11
Van-der-waals H8 H 837 8x53 G.h4s6 K 317 G.h4s6.11
Hydrophobic H8 L 841 8x57 G.H5 D 341 G.H5.13
Van-der-waals H8 L 841 8x57 G.H5 D 341 G.H5.13
Hydrophobic ICL3 F 765 - G.H5 I 344 G.H5.16
Polar TM4 Q 688 4x32 G.H5 C 351 G.H5.23
Hydrophobic TM4 Q 688 4x32 G.H5 C 351 G.H5.23
Van-der-waals TM4 Q 688 4x32 G.H5 C 351 G.H5.23
Hydrophobic ICL1 K 608 12x51 G.H5 G 352 G.H5.24
Van-der-waals ICL1 K 608 12x51 G.H5 G 352 G.H5.24
Polar H8 H 837 8x53 G.h4s6 K 314 G.h4s6.08
Hydrophobic H8 H 837 8x53 G.h4s6 K 314 G.h4s6.08
Van-der-waals H8 H 837 8x53 G.h4s6 K 314 G.h4s6.08
Hydrophobic H8 L 839 8x55 G.H5 D 341 G.H5.13
Hydrophobic ICL2 V 673 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 V 673 - G.H5 T 340 G.H5.12
Polar H8 H 837 8x53 G.h4s6 T 316 G.h4s6.10
Hydrophobic H8 H 837 8x53 G.h4s6 T 316 G.h4s6.10
Polar ICL2 G 676 - G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 G 676 - G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 G 676 - G.s2s3 K 192 G.s2s3.01
Hydrophobic C-term F 844 - G.H5 D 337 G.H5.09
Van-der-waals C-term F 844 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 F 765 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 F 765 - G.H5 L 348 G.H5.20
Polar ICL2 Q 678 - G.s2s3 D 193 G.s2s3.02
Van-der-waals TM6 E 767 6x35 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 666 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 683 - G.H5 E 350 G.H5.22
Polar TM2 G 611 2x35 G.H5 G 352 G.H5.24
Hydrophobic TM2 G 611 2x35 G.H5 G 352 G.H5.24
Van-der-waals TM2 G 611 2x35 G.H5 G 352 G.H5.24
Ionic H8 H 837 8x53 G.h4s6 E 318 G.h4s6.12
Polar H8 H 837 8x53 G.h4s6 E 318 G.h4s6.12
Hydrophobic H8 H 837 8x53 G.h4s6 E 318 G.h4s6.12
Van-der-waals H8 H 837 8x53 G.h4s6 E 318 G.h4s6.12
Polar ICL2 G 676 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 G 676 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 G 676 - G.s2s3 D 193 G.s2s3.02
Hydrophobic TM3 I 669 3x57 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 669 3x57 G.H5 N 347 G.H5.19
Hydrophobic ICL2 I 683 - G.H5 N 347 G.H5.19
Hydrophobic TM3 I 669 3x57 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 669 3x57 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 669 3x57 G.H5 L 348 G.H5.20
Ionic ICL2 R 679 - G.H5 E 350 G.H5.22
Polar ICL2 R 679 - G.H5 E 350 G.H5.22
Hydrophobic ICL2 R 679 - G.H5 E 350 G.H5.22
Van-der-waals ICL2 R 679 - G.H5 E 350 G.H5.22
Hydrophobic ICL2 V 673 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 V 673 - G.H5 I 344 G.H5.16
Hydrophobic C-term V 862 - G.h1ha D 59 G.h1ha.02
Van-der-waals C-term V 862 - G.h1ha D 59 G.h1ha.02
Ionic ICL2 K 681 - G.HN E 28 G.HN.52
Polar ICL2 K 681 - G.HN E 28 G.HN.52
Hydrophobic ICL2 K 681 - G.HN E 28 G.HN.52
Van-der-waals ICL2 K 681 - G.HN E 28 G.HN.52
Polar C-term Y 853 - G.H5 K 330 G.H5.02
Polar ICL2 Q 678 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 Q 678 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 Q 678 - G.hns1 K 32 G.hns1.03
Polar ICL2 I 683 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 I 683 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 I 683 - G.H5 C 351 G.H5.23
Polar TM3 C 665 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 C 665 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 C 665 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 G 676 - G.S3 L 194 G.S3.01
Polar H8 L 839 8x55 G.h4s6 E 318 G.h4s6.12
Hydrophobic H8 L 839 8x55 G.S6 Y 320 G.S6.02
Van-der-waals H8 L 839 8x55 G.S6 Y 320 G.S6.02
Polar C-term P 863 - G.h1ha D 59 G.h1ha.02
Hydrophobic C-term P 863 - G.h1ha D 59 G.h1ha.02
Van-der-waals C-term P 863 - G.h1ha D 59 G.h1ha.02
Hydrophobic ICL2 Q 678 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 Q 678 - G.S3 L 194 G.S3.01
Hydrophobic TM4 P 685 4x29 G.H5 C 351 G.H5.23
Aromatic C-term F 844 - G.H5 F 334 G.H5.06
Hydrophobic C-term F 844 - G.H5 F 334 G.H5.06
Van-der-waals C-term F 844 - G.H5 F 334 G.H5.06
Hydrophobic TM3 F 670 3x58 G.H5 L 348 G.H5.20
Hydrophobic ICL2 R 679 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 A 677 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 677 - G.H5 I 343 G.H5.15
Hydrophobic TM2 G 611 2x35 G.H5 L 353 G.H5.25
Van-der-waals TM2 G 611 2x35 G.H5 L 353 G.H5.25
Hydrophobic C-term V 865 - G.H1 K 54 G.H1.09
Hydrophobic ICL3 F 765 - G.H5 Y 354 G.H5.26
Hydrophobic ICL2 N 675 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 675 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 P 680 - G.H5 N 347 G.H5.19
Hydrophobic ICL1 A 609 12x52 G.H5 L 353 G.H5.25
Van-der-waals ICL1 A 609 12x52 G.H5 L 353 G.H5.25
Hydrophobic ICL1 K 608 12x51 G.H5 Y 354 G.H5.26
Hydrophobic TM4 P 685 4x29 G.H5 G 352 G.H5.24
Hydrophobic H8 V 835 8x51 G.H5 Y 354 G.H5.26
Van-der-waals H8 V 835 8x51 G.H5 Y 354 G.H5.26
Polar ICL1 K 608 12x51 G.H5 L 353 G.H5.25
Hydrophobic ICL1 K 608 12x51 G.H5 L 353 G.H5.25
Hydrophobic ICL1 S 610 12x53 G.H5 L 353 G.H5.25
Van-der-waals ICL1 S 610 12x53 G.H5 L 353 G.H5.25
Hydrophobic ICL1 A 609 12x52 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 N 675 - G.s2s3 K 192 G.s2s3.01