Gs - mGlu3 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 24.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 K 674 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 K 674 - G.hns1 R 38 G.hns1.02
Polar H8 V 834 8x50 G.H5 R 385 G.H5.17
Hydrophobic H8 H 837 8x53 G.H5 I 382 G.H5.14
Van-der-waals H8 H 837 8x53 G.H5 I 382 G.H5.14
Polar ICL2 K 674 - G.hns1 Y 37 G.hns1.01
Hydrophobic ICL2 K 674 - G.hns1 Y 37 G.hns1.01
Van-der-waals ICL2 K 674 - G.hns1 Y 37 G.hns1.01
Hydrophobic TM3 I 669 3x57 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 669 3x57 G.H5 L 393 G.H5.25
Hydrophobic ICL3 F 765 - G.H5 L 388 G.H5.20
Van-der-waals ICL3 F 765 - G.H5 L 388 G.H5.20
Polar ICL2 N 675 - G.HN K 34 G.HN.51
Hydrophobic ICL2 N 675 - G.HN K 34 G.HN.51
Van-der-waals ICL2 N 675 - G.HN K 34 G.HN.51
Polar TM3 R 668 3x56 G.hns1 R 38 G.hns1.02
Van-der-waals TM3 R 668 3x56 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 D 671 - G.HN K 34 G.HN.51
Van-der-waals ICL2 D 671 - G.HN K 34 G.HN.51
Hydrophobic H8 L 841 8x57 G.H4 L 346 G.H4.16
Van-der-waals H8 L 841 8x57 G.H4 L 346 G.H4.16
Hydrophobic ICL3 F 765 - G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 680 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 I 683 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 I 683 - G.H5 Y 391 G.H5.23
Hydrophobic ICL1 A 609 12x52 G.H5 L 394 G.H5.26
Van-der-waals ICL1 A 609 12x52 G.H5 L 394 G.H5.26
Hydrophobic C-term F 844 - G.H4 D 343 G.H4.13
Polar ICL3 F 765 - G.H5 Q 384 G.H5.16
Hydrophobic ICL3 F 765 - G.H5 Q 384 G.H5.16
Van-der-waals ICL3 F 765 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 V 673 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 V 673 - G.H5 Y 391 G.H5.23
Polar ICL2 K 674 - G.HN K 34 G.HN.51
Hydrophobic ICL2 K 674 - G.HN K 34 G.HN.51
Van-der-waals ICL2 K 674 - G.HN K 34 G.HN.51
Hydrophobic ICL2 P 680 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 P 680 - G.hns1 R 38 G.hns1.02
Polar ICL2 D 671 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 D 671 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 D 671 - G.HN Q 35 G.HN.52
Hydrophobic TM3 I 666 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 666 3x54 G.H5 L 393 G.H5.25
Polar ICL2 K 674 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 K 674 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 K 674 - G.HN Q 35 G.HN.52
Polar TM3 F 670 3x58 G.hns1 R 38 G.hns1.02
Hydrophobic TM3 F 670 3x58 G.hns1 R 38 G.hns1.02
Van-der-waals TM3 F 670 3x58 G.hns1 R 38 G.hns1.02
Hydrophobic C-term R 843 - G.hgh4 P 321 G.hgh4.11
Polar ICL2 N 675 - G.HN D 33 G.HN.50
Hydrophobic ICL2 N 675 - G.HN D 33 G.HN.50
Polar H8 K 832 8x48 G.H5 R 385 G.H5.17
Van-der-waals H8 K 832 8x48 G.H5 R 385 G.H5.17
Hydrophobic ICL2 R 679 - G.H5 Y 391 G.H5.23
Aromatic H8 R 838 8x54 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 C 665 3x53 G.H5 L 393 G.H5.25
Ionic ICL2 R 679 - G.H5 E 392 G.H5.24
Polar ICL2 R 679 - G.H5 E 392 G.H5.24
Hydrophobic ICL2 R 679 - G.H5 E 392 G.H5.24
Van-der-waals ICL2 R 679 - G.H5 E 392 G.H5.24
Polar TM4 S 684 4x28 G.H5 E 392 G.H5.24
Hydrophobic TM4 S 684 4x28 G.H5 E 392 G.H5.24
Van-der-waals TM4 S 684 4x28 G.H5 E 392 G.H5.24
Polar ICL3 N 764 - G.H5 Q 384 G.H5.16
Hydrophobic ICL3 N 764 - G.H5 Q 384 G.H5.16
Van-der-waals ICL3 N 764 - G.H5 Q 384 G.H5.16
Polar ICL2 G 672 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 G 672 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 G 672 - G.hns1 R 38 G.hns1.02
Polar C-term R 843 - G.hgh4 T 320 G.hgh4.10
Hydrophobic ICL2 I 683 - G.H5 E 392 G.H5.24
Van-der-waals ICL2 I 683 - G.H5 E 392 G.H5.24
Hydrophobic H8 L 839 8x55 G.H4 R 342 G.H4.12
Van-der-waals H8 L 839 8x55 G.H4 R 342 G.H4.12
Hydrophobic H8 L 841 8x57 G.h4s6 T 350 G.h4s6.03
Van-der-waals H8 L 841 8x57 G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 K 674 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 K 674 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 K 674 - G.HN D 33 G.HN.50
Van-der-waals ICL2 K 674 - G.HN D 33 G.HN.50
Hydrophobic ICL3 P 762 - G.S3 V 217 G.S3.01
Van-der-waals ICL3 P 762 - G.S3 V 217 G.S3.01
Ionic C-term R 843 - G.hgh4 E 322 G.hgh4.12
Polar C-term R 843 - G.hgh4 E 322 G.hgh4.12
Van-der-waals C-term R 843 - G.hgh4 E 322 G.hgh4.12
Hydrophobic ICL3 F 765 - G.H5 H 387 G.H5.19
Polar H8 H 837 8x53 G.S6 H 362 G.S6.04
Aromatic H8 H 837 8x53 G.S6 H 362 G.S6.04
Hydrophobic H8 H 837 8x53 G.S6 H 362 G.S6.04
Van-der-waals H8 H 837 8x53 G.S6 H 362 G.S6.04
Hydrophobic TM3 F 670 3x58 G.hns1 A 39 G.hns1.03
Polar H8 H 837 8x53 G.S6 P 361 G.S6.03
Hydrophobic H8 H 837 8x53 G.S6 P 361 G.S6.03
Van-der-waals H8 H 837 8x53 G.S6 P 361 G.S6.03
Hydrophobic ICL2 V 673 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 V 673 - G.hns1 R 38 G.hns1.02
Hydrophobic H8 L 839 8x55 G.S6 P 361 G.S6.03
Van-der-waals H8 L 839 8x55 G.S6 P 361 G.S6.03
Van-der-waals ICL1 A 609 12x52 G.H5 L 393 G.H5.25
Hydrophobic H8 L 839 8x55 G.hgh4 D 323 G.hgh4.13
Polar H8 H 840 8x56 G.hgh4 D 323 G.hgh4.13
Hydrophobic H8 H 840 8x56 G.hgh4 D 323 G.hgh4.13
Van-der-waals H8 H 840 8x56 G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 V 673 - G.h2s4 D 240 G.h2s4.03
Van-der-waals ICL2 V 673 - G.h2s4 D 240 G.h2s4.03
Hydrophobic C-term F 844 - G.H4 R 347 G.H4.17
Hydrophobic H8 L 839 8x55 G.H4 L 346 G.H4.16
Polar ICL2 N 675 - G.HN L 30 G.HN.47
Hydrophobic ICL2 N 675 - G.HN L 30 G.HN.47
Van-der-waals ICL2 N 675 - G.HN L 30 G.HN.47
Hydrophobic ICL2 A 677 - G.h2s4 D 240 G.h2s4.03
Van-der-waals ICL2 A 677 - G.h2s4 D 240 G.h2s4.03
Hydrophobic ICL1 K 608 12x51 G.H5 L 394 G.H5.26
Van-der-waals ICL1 K 608 12x51 G.H5 L 394 G.H5.26
Hydrophobic ICL2 V 673 - G.hns1 Y 37 G.hns1.01
Van-der-waals ICL2 V 673 - G.hns1 Y 37 G.hns1.01
Polar C-term R 843 - G.hgh4 T 319 G.hgh4.09
Van-der-waals C-term R 843 - G.hgh4 T 319 G.hgh4.09
Ionic H8 H 837 8x53 G.H5 D 378 G.H5.10
Polar H8 H 837 8x53 G.H5 D 378 G.H5.10
Polar ICL3 N 764 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 N 764 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 N 764 - G.H5 D 381 G.H5.13
Polar TM3 I 669 3x57 G.hns1 R 38 G.hns1.02
Hydrophobic TM3 I 669 3x57 G.hns1 R 38 G.hns1.02
Van-der-waals TM3 I 669 3x57 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 K 674 - G.HN V 36 G.HN.53
Van-der-waals ICL2 K 674 - G.HN V 36 G.HN.53
Hydrophobic ICL2 G 672 - G.HN K 34 G.HN.51
Hydrophobic ICL3 P 762 - G.H5 Q 384 G.H5.16
Van-der-waals ICL3 P 762 - G.H5 Q 384 G.H5.16
Aromatic H8 H 837 8x53 G.S6 Y 360 G.S6.02
Hydrophobic H8 H 837 8x53 G.S6 Y 360 G.S6.02
Van-der-waals H8 H 837 8x53 G.S6 Y 360 G.S6.02
Hydrophobic TM3 I 669 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 669 3x57 G.H5 Y 391 G.H5.23
Polar TM4 Q 688 4x32 G.H5 E 392 G.H5.24
Van-der-waals TM4 Q 688 4x32 G.H5 E 392 G.H5.24
Polar ICL2 R 679 - G.H5 Q 390 G.H5.22
Hydrophobic ICL2 R 679 - G.H5 Q 390 G.H5.22
Van-der-waals ICL2 R 679 - G.H5 Q 390 G.H5.22