Go - mGlu5 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 70.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.6
PAE mean: 15.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 S 676 - G.H5 T 340 G.H5.12
Polar C-term R 844 - G.S6 C 321 G.S6.03
Van-der-waals C-term R 844 - G.S6 C 321 G.S6.03
Van-der-waals C-term R 844 - G.S6 Y 320 G.S6.02
Hydrophobic ICL1 S 613 12x53 G.H5 L 353 G.H5.25
Polar H8 R 834 8x51 G.h4s6 N 316 G.h4s6.10
Hydrophobic H8 R 834 8x51 G.h4s6 N 316 G.h4s6.10
Van-der-waals H8 R 834 8x51 G.h4s6 N 316 G.h4s6.10
Polar ICL2 K 678 - G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 K 678 - G.s2s3 N 194 G.s2s3.02
Polar H8 T 839 8x56 G.H5 D 341 G.H5.13
Hydrophobic H8 T 839 8x56 G.H5 D 341 G.H5.13
Van-der-waals H8 T 839 8x56 G.H5 D 341 G.H5.13
Polar TM3 R 668 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 668 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 668 3x53 G.H5 C 351 G.H5.23
Hydrophobic C-term G 850 - G.h4s6 P 315 G.h4s6.09
Polar TM4 A 690 4x29 G.H5 C 351 G.H5.23
Hydrophobic ICL2 I 680 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 I 680 - G.S3 L 195 G.S3.01
Hydrophobic C-term V 847 - G.h4s6 P 315 G.h4s6.09
Van-der-waals C-term V 847 - G.h4s6 P 315 G.h4s6.09
Hydrophobic C-term M 845 - G.h4s6 E 318 G.h4s6.12
Van-der-waals C-term M 845 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 K 683 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 K 683 - G.hns1 A 31 G.hns1.02
Hydrophobic H8 T 839 8x56 G.H5 I 344 G.H5.16
Hydrophobic C-term G 848 - G.h4s6 P 315 G.h4s6.09
Van-der-waals C-term G 848 - G.h4s6 P 315 G.h4s6.09
Hydrophobic TM3 R 668 3x53 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 668 3x53 G.H5 L 353 G.H5.25
Hydrophobic C-term V 843 - G.H5 V 334 G.H5.06
Hydrophobic ICL2 T 682 - G.S1 V 34 G.S1.02
Hydrophobic ICL2 K 683 - G.HN I 28 G.HN.52
Van-der-waals ICL2 K 683 - G.HN I 28 G.HN.52
Polar C-term H 846 - G.S6 I 319 G.S6.01
Van-der-waals C-term H 846 - G.S6 I 319 G.S6.01
Polar ICL2 M 688 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 M 688 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 M 688 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 S 676 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 S 676 - G.H5 I 344 G.H5.16
Hydrophobic C-term V 847 - G.h4s6 E 318 G.h4s6.12
Polar C-term G 848 - G.h4s6 K 317 G.h4s6.11
Polar C-term G 848 - G.h4s6 S 314 G.h4s6.08
Hydrophobic C-term G 848 - G.h4s6 S 314 G.h4s6.08
Hydrophobic H8 S 840 8x57 G.H5 D 337 G.H5.09
Polar H8 S 840 8x57 G.H5 D 341 G.H5.13
Van-der-waals H8 S 840 8x57 G.H5 D 341 G.H5.13
Hydrophobic TM3 I 672 3x57 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 672 3x57 G.H5 N 347 G.H5.19
Hydrophobic C-term H 846 - G.h4s6 E 318 G.h4s6.12
Van-der-waals C-term H 846 - G.h4s6 E 318 G.h4s6.12
Hydrophobic C-term M 845 - G.S6 Y 320 G.S6.02
Van-der-waals C-term M 845 - G.S6 Y 320 G.S6.02
Hydrophobic ICL1 S 612 12x52 G.H5 L 353 G.H5.25
Van-der-waals ICL1 S 612 12x52 G.H5 L 353 G.H5.25
Polar ICL2 T 682 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 T 682 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 T 682 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 L 673 3x58 G.H5 I 344 G.H5.16
Van-der-waals TM3 L 673 3x58 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 672 3x57 G.H5 I 344 G.H5.16
Hydrophobic C-term V 843 - G.H5 D 337 G.H5.09
Hydrophobic C-term V 843 - G.H5 A 338 G.H5.10
Polar H8 R 834 8x51 G.H5 Y 354 G.H5.26
Hydrophobic H8 R 834 8x51 G.H5 Y 354 G.H5.26
Van-der-waals H8 R 834 8x51 G.H5 Y 354 G.H5.26
Polar H8 R 834 8x51 G.h4s6 P 315 G.h4s6.09
Van-der-waals H8 R 834 8x51 G.h4s6 P 315 G.h4s6.09
Polar ICL2 K 683 - G.HN G 27 G.HN.51
Hydrophobic ICL2 K 683 - G.HN G 27 G.HN.51
Van-der-waals ICL2 K 683 - G.HN G 27 G.HN.51
Hydrophobic C-term G 848 - G.h4s6 N 312 G.h4s6.02
Van-der-waals C-term G 848 - G.h4s6 N 312 G.h4s6.02
Hydrophobic TM3 I 672 3x57 G.H5 L 348 G.H5.20
Hydrophobic C-term M 845 - G.S6 I 319 G.S6.01
Van-der-waals C-term M 845 - G.S6 I 319 G.S6.01
Hydrophobic TM3 I 672 3x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 I 680 - G.H5 I 343 G.H5.15
Hydrophobic TM2 S 614 2x35 G.H5 L 353 G.H5.25
Van-der-waals TM2 S 614 2x35 G.H5 L 353 G.H5.25
Polar ICL2 T 682 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 T 682 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 T 682 - G.hns1 K 32 G.hns1.03
Ionic C-term H 846 - G.H4 E 309 G.H4.16
Hydrophobic C-term H 846 - G.H4 E 309 G.H4.16
Van-der-waals C-term H 846 - G.H4 E 309 G.H4.16
Ionic H8 R 834 8x51 G.h4s6 E 318 G.h4s6.12
Polar H8 R 834 8x51 G.h4s6 E 318 G.h4s6.12
Hydrophobic H8 R 834 8x51 G.h4s6 E 318 G.h4s6.12
Van-der-waals H8 R 834 8x51 G.h4s6 E 318 G.h4s6.12
Hydrophobic C-term V 843 - G.S6 Y 320 G.S6.02
Van-der-waals C-term V 843 - G.S6 Y 320 G.S6.02