Gi1 - HCA1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 L 209 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 H 121 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 H 121 34x51 G.S3 L 194 G.S3.01
Polar TM6 Q 212 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 Q 212 6x27 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 Q 212 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 A 218 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 T 126 34x56 G.hns1 A 31 G.hns1.02
Polar H8 S 284 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM3 V 117 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 117 3x54 G.H5 L 348 G.H5.20
Polar ICL3 R 206 - G.H5 D 337 G.H5.09
Hydrophobic ICL2 P 120 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 120 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM5 L 203 5x65 G.H5 I 344 G.H5.16
Ionic ICL3 R 206 - G.H5 D 341 G.H5.13
Polar ICL3 R 206 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 206 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 206 - G.H5 D 341 G.H5.13
Polar ICL2 H 121 34x51 G.H5 T 340 G.H5.12
Hydrophobic ICL2 H 121 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 H 121 34x51 G.H5 T 340 G.H5.12
Hydrophobic C-term V 343 - G.H2 R 208 G.H2.04
Polar TM6 Q 212 6x27 G.H5 K 345 G.H5.17
Hydrophobic TM6 Q 212 6x27 G.H5 K 345 G.H5.17
Van-der-waals TM6 Q 212 6x27 G.H5 K 345 G.H5.17
Polar H8 S 282 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 282 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 282 8x47 G.H5 G 352 G.H5.24
Polar TM3 K 116 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 K 116 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 116 3x53 G.H5 C 351 G.H5.23
Hydrophobic H8 P 283 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 P 283 8x48 G.H5 F 354 G.H5.26
Ionic TM2 K 48 2x37 G.H5 D 350 G.H5.22
Polar TM2 K 48 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 K 48 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 K 48 2x37 G.H5 D 350 G.H5.22
Polar TM3 R 113 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 113 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 113 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 F 221 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 F 221 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 113 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 120 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 120 34x50 G.H5 I 343 G.H5.15
Polar ICL3 Q 208 - G.S6 I 319 G.S6.01
Hydrophobic C-term V 343 - G.H2 I 212 G.H2.08
Van-der-waals C-term V 343 - G.H2 I 212 G.H2.08
Hydrophobic ICL3 R 206 - G.H5 T 340 G.H5.12
Van-der-waals ICL3 R 206 - G.H5 T 340 G.H5.12
Polar TM3 K 116 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 116 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 116 3x53 G.H5 N 347 G.H5.19
Polar TM2 S 50 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 50 2x39 G.H5 D 350 G.H5.22
Aromatic ICL2 H 121 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 H 121 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 H 121 34x51 G.H5 F 336 G.H5.08
Polar ICL3 L 209 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 M 215 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 M 215 6x30 G.H5 F 354 G.H5.26
Hydrophobic C-term W 345 - G.H2 I 212 G.H2.08
Van-der-waals C-term W 345 - G.H2 I 212 G.H2.08
Hydrophobic H8 P 283 8x48 G.H5 L 353 G.H5.25
Hydrophobic C-term W 345 - G.h2s4 F 215 G.h2s4.01
Van-der-waals C-term W 345 - G.h2s4 F 215 G.h2s4.01
Hydrophobic ICL2 T 126 34x56 G.HN E 28 G.HN.52
Van-der-waals ICL2 T 126 34x56 G.HN E 28 G.HN.52
Hydrophobic ICL2 P 120 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 203 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL3 Q 208 - G.S6 Y 320 G.S6.02
Hydrophobic TM6 M 215 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 M 215 6x30 G.H5 K 345 G.H5.17
Hydrophobic TM6 I 222 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM4 V 131 4x41 G.HN R 24 G.HN.48
Van-der-waals TM4 V 131 4x41 G.HN R 24 G.HN.48
Hydrophobic ICL3 L 209 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 L 209 - G.H5 K 345 G.H5.17
Hydrophobic ICL3 L 209 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 L 209 - G.H5 D 341 G.H5.13
Hydrophobic TM3 V 117 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 117 3x54 G.H5 I 344 G.H5.16
Hydrophobic H8 P 283 8x48 G.H5 G 352 G.H5.24
Polar TM4 S 128 4x38 G.HN R 24 G.HN.48
Hydrophobic TM4 S 128 4x38 G.HN R 24 G.HN.48
Van-der-waals TM4 S 128 4x38 G.HN R 24 G.HN.48
Ionic TM4 R 130 4x40 G.HN D 20 G.HN.44
Polar TM4 R 130 4x40 G.HN D 20 G.HN.44
Hydrophobic TM4 R 130 4x40 G.HN D 20 G.HN.44
Van-der-waals TM4 R 130 4x40 G.HN D 20 G.HN.44
Hydrophobic ICL3 Q 208 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 Q 208 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 H 121 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 H 121 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM6 M 215 6x30 G.H5 L 348 G.H5.20
Van-der-waals TM6 M 215 6x30 G.H5 L 348 G.H5.20
Hydrophobic ICL3 R 206 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 R 206 - G.H5 I 344 G.H5.16
Polar TM3 D 112 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 D 112 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM6 R 214 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 214 6x29 G.H5 F 354 G.H5.26