G12 - H3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 N 69 2x39 G.H5 D 377 G.H5.22
Hydrophobic ICL2 R 143 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 R 143 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM6 F 348 6x25 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 F 348 6x25 G.h4s6 S 343 G.h4s6.12
Polar TM6 R 352 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM6 R 352 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 352 6x29 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 V 140 34x51 G.H5 F 363 G.H5.08
Van-der-waals TM6 R 349 6x26 G.S6 F 347 G.S6.02
Hydrophobic TM6 R 352 6x29 G.H5 L 375 G.H5.20
Van-der-waals TM6 R 352 6x29 G.H5 L 375 G.H5.20
Hydrophobic TM6 I 363 6x40 G.H5 L 380 G.H5.25
Hydrophobic TM3 R 132 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM7 C 415 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 C 415 7x56 G.H5 L 380 G.H5.25
Polar ICL2 A 144 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 A 144 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 A 144 34x55 G.hns1 R 56 G.hns1.03
Ionic TM5 R 232 5x72 G.H5 D 368 G.H5.13
Polar TM5 R 232 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM5 R 232 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 232 5x72 G.H5 D 368 G.H5.13
Hydrophobic ICL2 V 140 34x51 G.S1 V 58 G.S1.02
Ionic H8 H 416 8x47 G.H5 D 377 G.H5.22
Polar H8 H 416 8x47 G.H5 D 377 G.H5.22
Hydrophobic H8 H 416 8x47 G.H5 D 377 G.H5.22
Van-der-waals H8 H 416 8x47 G.H5 D 377 G.H5.22
Ionic ICL2 R 143 34x54 G.H5 E 373 G.H5.18
Polar ICL2 R 143 34x54 G.H5 E 373 G.H5.18
Van-der-waals ICL2 R 143 34x54 G.H5 E 373 G.H5.18
Hydrophobic ICL3 T 345 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 T 345 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 R 228 5x68 G.H5 K 367 G.H5.12
Polar TM3 S 135 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 135 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 135 3x53 G.H5 N 374 G.H5.19
Ionic TM6 R 349 6x26 G.H5 D 368 G.H5.13
Polar TM6 R 349 6x26 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 349 6x26 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 352 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 352 6x29 G.H5 M 379 G.H5.24
Hydrophobic TM7 L 411 7x52 G.H5 L 380 G.H5.25
Van-der-waals TM7 L 411 7x52 G.H5 L 380 G.H5.25
Hydrophobic C-term W 444 - G.H2 W 238 G.H2.07
Hydrophobic C-term W 444 - G.H3 T 279 G.H3.11
Hydrophobic ICL2 A 139 34x50 G.H5 L 371 G.H5.16
Polar ICL2 R 143 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 R 143 34x54 G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 R 143 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic TM3 V 136 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 136 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM6 K 355 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 355 6x32 G.H5 M 379 G.H5.24
Hydrophobic ICL2 A 139 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 A 139 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM6 V 356 6x33 G.H5 I 378 G.H5.23
Hydrophobic TM6 V 356 6x33 G.H5 L 375 G.H5.20
Polar ICL3 S 341 - G.H4 D 336 G.H4.16
Van-der-waals ICL3 S 341 - G.H4 D 336 G.H4.16
Hydrophobic C-term W 444 - G.H2 R 235 G.H2.04
Polar TM6 S 359 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM6 S 359 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 S 359 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM7 C 415 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 C 415 7x56 G.H5 M 379 G.H5.24
Polar TM6 S 359 6x36 G.H5 I 378 G.H5.23
Hydrophobic TM6 S 359 6x36 G.H5 I 378 G.H5.23
Van-der-waals TM6 S 359 6x36 G.H5 I 378 G.H5.23
Hydrophobic C-term W 444 - G.H3 I 280 G.H3.12
Ionic TM4 D 148 4x38 G.hns1 R 56 G.hns1.03
Polar TM4 D 148 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 D 148 4x38 G.hns1 R 56 G.hns1.03
Polar ICL1 R 66 12x51 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 V 140 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM5 I 225 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 I 225 5x65 G.H5 L 375 G.H5.20
Polar TM3 R 132 3x50 G.H5 D 377 G.H5.22
Hydrophobic TM6 L 360 6x37 G.H5 I 378 G.H5.23
Van-der-waals TM6 L 360 6x37 G.H5 I 378 G.H5.23
Hydrophobic TM6 R 349 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 R 349 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 R 228 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 228 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM3 V 136 3x54 G.H5 L 371 G.H5.16
Hydrophobic C-term W 444 - G.h2s4 F 242 G.h2s4.01
Hydrophobic TM3 V 136 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 136 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM6 S 359 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 359 6x36 G.H5 M 379 G.H5.24
Polar H8 R 420 8x51 G.H5 Q 381 G.H5.26
Hydrophobic H8 R 420 8x51 G.H5 Q 381 G.H5.26
Van-der-waals H8 R 420 8x51 G.H5 Q 381 G.H5.26
Hydrophobic TM6 V 362 6x39 G.H5 L 380 G.H5.25
Van-der-waals TM6 V 362 6x39 G.H5 L 380 G.H5.25
Hydrophobic ICL2 G 147 34x58 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 V 140 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 140 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 V 140 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM6 V 356 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 356 6x33 G.H5 M 379 G.H5.24
Hydrophobic C-term L 440 - G.H3 L 285 G.H3.17
Van-der-waals C-term L 440 - G.H3 L 285 G.H3.17