G15 - kisspeptin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term L 366 - G.H3 I 261 G.H3.12
Polar H8 S 328 8x48 G.H5 N 372 G.H5.24
Van-der-waals H8 S 328 8x48 G.H5 N 372 G.H5.24
Hydrophobic ICL2 L 148 34x51 G.S3 T 202 G.S3.01
Hydrophobic ICL2 L 148 34x51 G.H5 V 359 G.H5.11
Polar ICL2 L 151 34x54 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 L 151 34x54 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 L 151 34x54 G.H5 Y 367 G.H5.19
Ionic C-term H 369 - G.s4h3 E 248 G.s4h3.14
Polar C-term H 369 - G.s4h3 E 248 G.s4h3.14
Hydrophobic C-term H 369 - G.s4h3 E 248 G.s4h3.14
Van-der-waals C-term H 369 - G.s4h3 E 248 G.s4h3.14
Hydrophobic ICL2 R 154 34x57 G.H5 Y 367 G.H5.19
Hydrophobic TM6 V 261 6x33 G.H5 L 373 G.H5.25
Van-der-waals TM6 V 261 6x33 G.H5 L 373 G.H5.25
Polar H8 H 329 8x49 G.H5 N 372 G.H5.24
Hydrophobic H8 H 329 8x49 G.H5 N 372 G.H5.24
Van-der-waals H8 H 329 8x49 G.H5 N 372 G.H5.24
Hydrophobic ICL2 L 148 34x51 G.H5 R 360 G.H5.12
Hydrophobic ICL2 L 151 34x54 G.H5 V 363 G.H5.15
Hydrophobic H8 H 329 8x49 G.H5 E 370 G.H5.22
Polar TM5 Q 246 5x80 G.S6 S 341 G.S6.03
Van-der-waals TM5 Q 246 5x80 G.S6 S 341 G.S6.03
Hydrophobic TM6 V 257 6x29 G.H5 L 368 G.H5.20
Ionic H8 H 329 8x49 G.H5 D 369 G.H5.21
Polar H8 H 329 8x49 G.H5 D 369 G.H5.21
Hydrophobic H8 H 329 8x49 G.H5 D 369 G.H5.21
Van-der-waals H8 H 329 8x49 G.H5 D 369 G.H5.21
Hydrophobic C-term V 390 - G.h1ha A 68 G.h1ha.02
Van-der-waals C-term V 390 - G.h1ha A 68 G.h1ha.02
Polar C-term L 366 - G.H2 R 216 G.H2.04
Hydrophobic C-term L 366 - G.H2 R 216 G.H2.04
Van-der-waals C-term L 366 - G.H2 R 216 G.H2.04
Hydrophobic TM4 T 155 4x38 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 P 147 34x50 G.H5 R 360 G.H5.12
Van-der-waals ICL2 P 147 34x50 G.H5 R 360 G.H5.12
Hydrophobic C-term E 362 - G.H3 L 264 G.H3.15
Hydrophobic C-term L 366 - G.H3 T 260 G.H3.11
Hydrophobic C-term L 388 - G.H1 R 63 G.H1.09
Van-der-waals C-term L 388 - G.H1 R 63 G.H1.09
Hydrophobic C-term L 363 - G.H2 I 220 G.H2.08
Van-der-waals C-term L 363 - G.H2 I 220 G.H2.08
Polar TM6 K 260 6x32 G.H5 N 372 G.H5.24
Hydrophobic TM6 K 260 6x32 G.H5 N 372 G.H5.24
Van-der-waals TM6 K 260 6x32 G.H5 N 372 G.H5.24
Hydrophobic TM6 V 257 6x29 G.H5 L 374 G.H5.26
Van-der-waals TM6 V 257 6x29 G.H5 L 374 G.H5.26
Polar TM2 V 76 2x38 G.H5 E 370 G.H5.22
Polar TM2 T 77 2x39 G.H5 E 370 G.H5.22
Hydrophobic TM2 T 77 2x39 G.H5 E 370 G.H5.22
Van-der-waals TM2 T 77 2x39 G.H5 E 370 G.H5.22
Polar ICL2 H 152 34x55 G.S1 E 42 G.S1.01
Hydrophobic C-term L 366 - G.H3 L 264 G.H3.15
Hydrophobic C-term L 366 - G.H3 L 257 G.H3.08
Van-der-waals C-term L 366 - G.H3 L 257 G.H3.08
Hydrophobic TM3 V 143 3x53 G.H5 I 371 G.H5.23
Hydrophobic ICL2 P 147 34x50 G.H5 L 364 G.H5.16
Polar ICL2 A 150 34x53 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 A 150 34x53 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 A 150 34x53 G.H5 Y 367 G.H5.19
Hydrophobic C-term E 362 - G.H3 P 265 G.H3.16
Van-der-waals C-term E 362 - G.H3 P 265 G.H3.16
Hydrophobic C-term V 390 - G.h1ha G 67 G.h1ha.01
Hydrophobic ICL2 L 148 34x51 G.H5 F 356 G.H5.08
Van-der-waals ICL2 L 148 34x51 G.H5 F 356 G.H5.08
Hydrophobic ICL2 L 151 34x54 G.S1 L 43 G.S1.02
Van-der-waals ICL2 L 151 34x54 G.S1 L 43 G.S1.02
Hydrophobic TM5 L 231 5x65 G.H5 L 368 G.H5.20
Polar ICL2 H 152 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 H 152 34x55 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 H 152 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 H 152 34x55 G.S1 L 43 G.S1.02
Hydrophobic TM5 S 243 5x77 G.H4 L 313 G.H4.12
Hydrophobic ICL2 L 148 34x51 G.S1 L 43 G.S1.02
Van-der-waals ICL2 L 148 34x51 G.S1 L 43 G.S1.02
Hydrophobic ICL2 P 147 34x50 G.H5 V 363 G.H5.15
Van-der-waals ICL2 P 147 34x50 G.H5 V 363 G.H5.15
Hydrophobic TM5 M 227 5x61 G.H5 L 373 G.H5.25
Hydrophobic C-term L 363 - G.H2 K 217 G.H2.05
Hydrophobic H8 G 327 8x47 G.H5 N 372 G.H5.24
Van-der-waals H8 G 327 8x47 G.H5 N 372 G.H5.24
Hydrophobic C-term H 369 - G.H2 K 213 G.H2.01
Van-der-waals C-term H 369 - G.H2 K 213 G.H2.01
Hydrophobic C-term P 359 - G.H2 I 220 G.H2.08
Van-der-waals C-term P 359 - G.H2 I 220 G.H2.08
Hydrophobic ICL2 P 147 34x50 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 P 147 34x50 G.H5 Y 367 G.H5.19
Hydrophobic C-term L 366 - G.H2 W 219 G.H2.07
Hydrophobic ICL2 L 148 34x51 G.H5 V 363 G.H5.15
Hydrophobic TM3 V 143 3x53 G.H5 Y 367 G.H5.19
Hydrophobic TM6 L 264 6x36 G.H5 L 373 G.H5.25
Van-der-waals TM6 L 264 6x36 G.H5 L 373 G.H5.25
Hydrophobic TM5 L 231 5x65 G.H5 L 364 G.H5.16
Hydrophobic TM2 T 77 2x39 G.H5 I 371 G.H5.23
Van-der-waals TM2 T 77 2x39 G.H5 I 371 G.H5.23
Polar ICL2 H 152 34x55 G.hns1 G 41 G.hns1.03
Hydrophobic ICL2 H 152 34x55 G.hns1 G 41 G.hns1.03
Van-der-waals ICL2 H 152 34x55 G.hns1 G 41 G.hns1.03
Van-der-waals C-term L 388 - G.S2 C 196 G.S2.05
Hydrophobic TM3 T 144 3x54 G.H5 L 364 G.H5.16
Van-der-waals TM3 T 144 3x54 G.H5 L 364 G.H5.16
Hydrophobic ICL2 L 151 34x54 G.H5 R 366 G.H5.18
Van-der-waals ICL2 L 151 34x54 G.H5 R 366 G.H5.18
Hydrophobic ICL2 L 151 34x54 G.h2s4 I 227 G.h2s4.05
Polar TM6 K 260 6x32 G.H5 L 374 G.H5.26
Hydrophobic TM6 K 260 6x32 G.H5 L 374 G.H5.26
Van-der-waals TM6 K 260 6x32 G.H5 L 374 G.H5.26
Polar H8 S 328 8x48 G.h4s6 R 335 G.h4s6.17
Hydrophobic H8 S 328 8x48 G.h4s6 R 335 G.h4s6.17
Van-der-waals H8 S 328 8x48 G.h4s6 R 335 G.h4s6.17
Polar TM5 D 242 5x76 G.S6 Y 343 G.S6.05
Hydrophobic TM5 D 242 5x76 G.S6 Y 343 G.S6.05
Van-der-waals TM5 D 242 5x76 G.S6 Y 343 G.S6.05
Polar TM2 T 75 2x37 G.H5 E 370 G.H5.22
Hydrophobic TM2 T 75 2x37 G.H5 E 370 G.H5.22
Van-der-waals TM2 T 75 2x37 G.H5 E 370 G.H5.22
Hydrophobic TM3 R 140 3x50 G.H5 I 371 G.H5.23
Hydrophobic C-term P 359 - G.H3 W 266 G.H3.17
Van-der-waals C-term P 359 - G.H3 W 266 G.H3.17
Polar C-term C 389 - G.S2 C 196 G.S2.05
Hydrophobic C-term C 389 - G.S2 C 196 G.S2.05
Van-der-waals C-term C 389 - G.S2 C 196 G.S2.05
Ionic ICL2 R 154 34x57 G.H5 E 370 G.H5.22
Polar ICL2 R 154 34x57 G.H5 E 370 G.H5.22
Hydrophobic ICL2 R 154 34x57 G.H5 E 370 G.H5.22
Van-der-waals ICL2 R 154 34x57 G.H5 E 370 G.H5.22
Hydrophobic TM6 K 260 6x32 G.H5 L 373 G.H5.25
Van-der-waals TM6 K 260 6x32 G.H5 L 373 G.H5.25