GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | I | 138 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | TM2 | F | 66 | 2x39 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM2 | F | 66 | 2x39 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL2 | I | 138 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | I | 138 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Polar | TM6 | S | 223 | 6x30 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | S | 223 | 6x30 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | L | 299 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | L | 299 | - | G.H2 | I | 220 | G.H2.08 |
Polar | H8 | G | 284 | 8x47 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | H8 | K | 288 | 8x51 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | H8 | K | 288 | 8x51 | G.H5 | L | 373 | G.H5.25 |
Polar | TM3 | R | 130 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | R | 130 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | V | 134 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | V | 134 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Aromatic | ICL2 | Y | 140 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | Y | 140 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | Y | 140 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM5 | W | 219 | 5x68 | G.S6 | L | 339 | G.S6.01 |
Van-der-waals | TM5 | W | 219 | 5x68 | G.S6 | L | 339 | G.S6.01 |
Hydrophobic | TM5 | I | 214 | 5x63 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM5 | I | 214 | 5x63 | G.H5 | L | 368 | G.H5.20 |
Polar | ICL2 | H | 143 | 34x56 | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | ICL2 | H | 143 | 34x56 | G.s2s3 | K | 201 | G.s2s3.02 |
Van-der-waals | ICL2 | H | 143 | 34x56 | G.s2s3 | K | 201 | G.s2s3.02 |
Polar | ICL2 | R | 141 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | R | 141 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | R | 141 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Polar | ICL2 | C | 142 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | ICL2 | C | 142 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Van-der-waals | ICL2 | C | 142 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Polar | ICL2 | C | 142 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | C | 142 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | C | 142 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM2 | I | 70 | 2x43 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM2 | I | 70 | 2x43 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL3 | A | 220 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | ICL3 | A | 220 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | ICL2 | I | 138 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | I | 138 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | ICL2 | R | 141 | 34x54 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | TM3 | V | 134 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM3 | V | 134 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL2 | I | 138 | 34x51 | G.H5 | V | 363 | G.H5.15 |
Polar | ICL2 | R | 141 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | R | 141 | 34x54 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM6 | L | 226 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM6 | L | 226 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM6 | K | 225 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Polar | ICL2 | R | 144 | 34x57 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | R | 144 | 34x57 | G.hns1 | R | 40 | G.hns1.02 |
Aromatic | TM5 | W | 219 | 5x68 | G.S6 | F | 340 | G.S6.02 |
Hydrophobic | TM5 | W | 219 | 5x68 | G.S6 | F | 340 | G.S6.02 |
Van-der-waals | TM5 | W | 219 | 5x68 | G.S6 | F | 340 | G.S6.02 |
Hydrophobic | TM7 | Y | 280 | 7x53 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM7 | Y | 280 | 7x53 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM3 | S | 133 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | S | 133 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | I | 138 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | ICL2 | P | 137 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | P | 137 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | H8 | V | 298 | 8x61 | G.H3 | P | 265 | G.H3.16 |
Van-der-waals | H8 | V | 298 | 8x61 | G.H3 | P | 265 | G.H3.16 |
Hydrophobic | ICL3 | H | 222 | - | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | ICL3 | H | 222 | - | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM5 | N | 217 | 5x66 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | N | 217 | 5x66 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | ICL2 | P | 137 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | P | 137 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM2 | F | 66 | 2x39 | G.H5 | Y | 367 | G.H5.19 |
Ionic | H8 | K | 288 | 8x51 | G.H5 | D | 369 | G.H5.21 |
Polar | H8 | K | 288 | 8x51 | G.H5 | D | 369 | G.H5.21 |
Van-der-waals | H8 | K | 288 | 8x51 | G.H5 | D | 369 | G.H5.21 |
Polar | H8 | R | 290 | 8x53 | G.h4s6 | S | 330 | G.h4s6.12 |
Hydrophobic | ICL2 | P | 137 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Polar | TM6 | L | 226 | 6x33 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | L | 226 | 6x33 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | C | 142 | 34x55 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | C | 142 | 34x55 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | TM5 | L | 210 | 5x59 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | H8 | L | 295 | 8x58 | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | TM6 | L | 226 | 6x33 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM6 | L | 226 | 6x33 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | ICL2 | R | 141 | 34x54 | G.h2s4 | I | 227 | G.h2s4.05 |
Van-der-waals | ICL2 | R | 141 | 34x54 | G.h2s4 | I | 227 | G.h2s4.05 |
Ionic | C-term | E | 306 | - | G.H2 | K | 217 | G.H2.05 |
Polar | C-term | E | 306 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | E | 306 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | E | 306 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | ICL2 | C | 142 | 34x55 | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | TM7 | I | 279 | 7x52 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM7 | I | 279 | 7x52 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM4 | K | 146 | 4x39 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | TM4 | K | 146 | 4x39 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | H8 | G | 284 | 8x47 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | H8 | G | 284 | 8x47 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | H8 | G | 284 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM5 | W | 219 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM3 | V | 134 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | V | 134 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Polar | TM6 | S | 223 | 6x30 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | TM6 | S | 223 | 6x30 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | TM6 | S | 223 | 6x30 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | C-term | L | 299 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | ICL2 | R | 141 | 34x54 | G.H5 | R | 366 | G.H5.18 |
Hydrophobic | ICL2 | P | 137 | 34x50 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM3 | R | 130 | 3x50 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM3 | R | 130 | 3x50 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | H8 | R | 290 | 8x53 | G.h4s6 | K | 332 | G.h4s6.14 |