G12 - NK3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 72.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 279 5x70 G.H5 D 368 G.H5.13
Hydrophobic ICL2 P 190 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 190 - G.H5 I 370 G.H5.15
Hydrophobic TM3 I 187 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 187 3x54 G.H5 L 371 G.H5.16
Polar ICL2 P 190 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 P 190 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 P 190 - G.hns1 R 56 G.hns1.03
Hydrophobic TM3 I 187 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM6 K 286 6x22 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 K 286 6x22 G.h4s6 P 345 G.h4s6.20
Polar TM2 N 121 2x40 G.H5 Q 381 G.H5.26
Hydrophobic TM2 N 121 2x40 G.H5 Q 381 G.H5.26
Van-der-waals TM2 N 121 2x40 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 294 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 K 294 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM2 L 124 2x43 G.H5 Q 381 G.H5.26
Hydrophobic TM5 P 280 5x71 G.H5 F 361 G.H5.06
Van-der-waals TM5 P 280 5x71 G.H5 F 361 G.H5.06
Polar TM6 K 286 6x22 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM6 K 286 6x22 G.h4s6 K 344 G.h4s6.19
Van-der-waals TM6 K 286 6x22 G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL2 L 191 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 191 - G.H5 F 363 G.H5.08
Van-der-waals TM5 E 278 5x69 G.H5 H 364 G.H5.09
Ionic ICL1 R 117 12x51 G.HN D 44 G.HN.44
Polar ICL1 R 117 12x51 G.HN D 44 G.HN.44
Hydrophobic TM4 S 196 4x38 G.HN R 52 G.HN.52
Polar C-term E 407 - G.H2 Q 236 G.H2.05
Van-der-waals C-term E 407 - G.H2 Q 236 G.H2.05
Ionic H8 R 362 8x49 G.H5 D 377 G.H5.22
Hydrophobic TM3 I 187 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 187 3x54 G.H5 I 378 G.H5.23
Polar TM4 A 197 4x39 G.HN R 52 G.HN.52
Hydrophobic TM4 A 197 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 A 197 4x39 G.HN R 52 G.HN.52
Hydrophobic ICL2 L 191 - G.H5 V 366 G.H5.11
Hydrophobic TM6 A 293 6x29 G.H5 M 379 G.H5.24
Hydrophobic TM5 P 280 5x71 G.S6 F 347 G.S6.02
Van-der-waals TM5 P 280 5x71 G.S6 F 347 G.S6.02
Hydrophobic ICL2 P 190 - G.H5 L 371 G.H5.16
Polar H8 N 360 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 N 360 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 N 360 8x47 G.H5 M 379 G.H5.24
Polar TM6 Q 290 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 Q 290 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 Q 290 6x26 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 L 191 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 191 - G.H5 I 370 G.H5.15
Hydrophobic TM6 K 294 6x30 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 191 - G.H5 K 367 G.H5.12
Ionic ICL2 R 194 - G.H5 D 377 G.H5.22
Polar ICL2 R 194 - G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 194 - G.H5 D 377 G.H5.22
Hydrophobic TM7 L 359 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 L 359 7x56 G.H5 M 379 G.H5.24
Polar ICL1 K 114 12x48 G.HN S 40 G.HN.40
Hydrophobic ICL2 L 191 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 191 - G.S3 I 221 G.S3.01
Hydrophobic H8 F 363 8x50 G.H5 Q 381 G.H5.26
Van-der-waals H8 F 363 8x50 G.H5 Q 381 G.H5.26
Hydrophobic TM6 V 297 6x33 G.H5 L 375 G.H5.20
Hydrophobic C-term F 392 - G.H3 K 284 G.H3.16
Van-der-waals C-term F 392 - G.H3 K 284 G.H3.16
Hydrophobic C-term F 392 - G.H3 L 285 G.H3.17
Polar ICL2 K 192 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 K 192 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 K 192 - G.hns1 R 56 G.hns1.03
Polar TM3 R 183 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 183 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM5 L 274 5x65 G.H5 L 375 G.H5.20
Ionic TM6 K 294 6x30 G.H5 D 368 G.H5.13
Polar TM6 K 294 6x30 G.H5 D 368 G.H5.13
Van-der-waals TM6 K 294 6x30 G.H5 D 368 G.H5.13
Van-der-waals ICL3 T 283 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 L 191 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 L 191 - G.hns1 R 56 G.hns1.03
Hydrophobic TM7 Y 356 7x53 G.H5 Q 381 G.H5.26
Van-der-waals TM7 Y 356 7x53 G.H5 Q 381 G.H5.26
Hydrophobic TM3 A 186 3x53 G.H5 I 378 G.H5.23
Polar H8 N 360 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 N 360 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 360 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM5 P 280 5x71 G.H5 A 365 G.H5.10
Polar ICL3 T 283 - G.S6 L 346 G.S6.01
Hydrophobic ICL3 T 283 - G.S6 L 346 G.S6.01
Van-der-waals ICL3 T 283 - G.S6 L 346 G.S6.01
Polar TM2 T 120 2x39 G.H5 Q 381 G.H5.26
Hydrophobic TM2 T 120 2x39 G.H5 Q 381 G.H5.26
Van-der-waals TM2 T 120 2x39 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 L 191 - G.S1 V 58 G.S1.02
Hydrophobic TM6 K 296 6x32 G.H5 M 379 G.H5.24
Van-der-waals ICL2 P 190 - G.H5 N 374 G.H5.19
Hydrophobic TM5 L 274 5x65 G.H5 L 371 G.H5.16
Polar ICL2 R 194 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 194 - G.H5 N 374 G.H5.19
Hydrophobic TM5 G 281 5x72 G.S6 H 348 G.S6.03
Hydrophobic ICL2 P 193 - G.hns1 R 56 G.hns1.03
Hydrophobic H8 K 361 8x48 G.H5 L 380 G.H5.25
Polar TM3 A 186 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 186 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 186 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM6 K 286 6x22 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 K 286 6x22 G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL2 P 193 - G.hns1 R 55 G.hns1.02
Hydrophobic TM5 P 280 5x71 G.H5 H 364 G.H5.09
Van-der-waals TM5 P 280 5x71 G.H5 H 364 G.H5.09
Polar TM6 K 286 6x22 G.h4s6 R 342 G.h4s6.11
Hydrophobic TM6 K 286 6x22 G.h4s6 R 342 G.h4s6.11
Van-der-waals TM6 K 286 6x22 G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL2 P 190 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 190 - G.H5 K 367 G.H5.12
Hydrophobic TM6 M 300 6x36 G.H5 I 378 G.H5.23
Hydrophobic ICL3 T 283 - G.S6 H 348 G.S6.03
Polar TM3 R 183 3x50 G.H5 Q 381 G.H5.26
Van-der-waals TM3 R 183 3x50 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 294 6x30 G.H5 L 375 G.H5.20
Hydrophobic TM5 I 279 5x70 G.S6 F 347 G.S6.02
Van-der-waals TM5 I 279 5x70 G.S6 F 347 G.S6.02
Van-der-waals TM6 K 286 6x22 G.h4s6 R 339 G.h4s6.08
Polar TM4 T 198 4x40 G.HN R 52 G.HN.52
Hydrophobic TM4 T 198 4x40 G.HN R 52 G.HN.52
Van-der-waals TM4 T 198 4x40 G.HN R 52 G.HN.52
Hydrophobic TM6 Q 290 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 Q 290 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 V 297 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 297 6x33 G.H5 M 379 G.H5.24
Hydrophobic H8 R 362 8x49 G.H5 L 380 G.H5.25